Results 1 to 10 of about 4,735 (197)

Preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice. [PDF]

PLoS ONE, 2013
BACKGROUND:The prostate cancer prevention trial (PCPT) and Reduction by dutasteride of Prostate Cancer Events (REDUCE) trial found that 5α-reductase (5αR) inhibitors finasteride and dutasteride respectively, decreased prostate cancer prevalence but also ...
Alexander B Opoku-Acheampong, Dave Unis, Jamie N Henningson, Amanda P Beck, Brian L Lindshield   +4 more
doaj   +3 more sources

Ameliorative potentials of Aju Mbaise extract (AME) on Dutasteride induced oxidative stress and hepatic injury in rats

Journal of Herbal Drugs, 2023
Background & Aim: Aju Mbaise is a polyherbal extract with nutraceutical properties that helps to replenish the volume of blood lost during childbirth and improves breast milk secretion and the general wellbeing of the mother.
Robert Ikechukwu Uroko, Elisha Uko Ogwo , Paul Nweje-Anyalowu , Ikenna Obiwuru, Chinomso Friday Aaron, Obinna Joseph Mba   +5 more
doaj   +2 more sources

Dutasteride treatment and its effect on standardized uptake values in prostate-specific membrane antigen-PET imaging: A pilot study. [PDF]

PLoS ONE
BackgroundProstate-specific membrane antigen (PSMA)-based imaging has become an increasingly important diagnostic tool in prostate cancer, though limited by low surface expression of PSMA in some patients.
Lucas Praetzel, Irene A Burger, Jan H Rüschoff, Niels J Rupp, Daniel Eberli, Benedikt Kranzbühler   +5 more
doaj   +2 more sources

A Robust and Universal LC-MS/MS Method for Determination of N-Nitrosodimethylamine in Pharmaceuticals Using a C30 Column. [PDF]

J Sep Sci
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
An B, Kim U, Seo S, Kim J, Jeong C, Jeong W, Ko E, Kim J, Cho HD, Han SB.   +9 more
europepmc   +2 more sources

Effects of dutasteride with Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and survival in non-muscle invasive bladder cancer: a retrospective single-center study [PDF]

BMC Urology
Background To evaluate the impact of dutasteride, a 5-alpha reductase inhibitor, used alongside intravesical Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and disease-free survival in non-muscle invasive bladder cancer patients.
Ali Nebioğlu, Mert Başaranoğlu, Murat Bozlu, Mesut Tek, Erdem Akbay   +4 more
doaj   +2 more sources

The effects of dutasteride and tamsulosin, alone or in association, in the kidney morphology: experimental study in rats [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate the renal morphology after isolated and combined administration of dutasteride and tamsulosin in rats. Methods: Forty male rats were divided in groups: control group; D, receiving 0.5 mg/kg/day of dutasteride; T, receiving 0.4 mg/kg/
Marcello Henrique Araujo da Silva, Simone Gomes Ferreira, Bianca Martins Gregório, Francisco José Sampaio, Diogo Benchimol de Souza   +4 more
doaj   +3 more sources

Efficacy of Hair Mesotherapy With Biomimetic Peptides and Micronutrients in Patients With Androgenetic Alopecia: A Retrospective Observational Study [PDF]

J Cosmet Dermatol
ABSTRACT Background Hair mesotherapy is increasingly used in the management of androgenetic alopecia (AGA), yet standardized treatment protocols and controlled clinical data are limited. Aims This study aimed to evaluate the efficacy and safety of a mesotherapy formulation containing biomimetic peptides, vitamins, and micronutrients in patients with ...
Köse Ö, Borlu M.
europepmc   +2 more sources

Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson’s Disease Models

Frontiers in Pharmacology, 2022
Gastrointestinal disorders in Parkinson’s disease (PD) have been associated with neuronal alteration in the plexus of the gut. We previously demonstrated the immunomodulatory effect of female hormones to treat enteric neurodegeneration in the 1-methyl-4 ...
Andrée-Anne Poirier, Andrée-Anne Poirier, Mélissa Côté, Hend Jarras, Hend Jarras, Nadhir Litim, Nadhir Litim, Jérôme Lamontagne-Proulx, Jérôme Lamontagne-Proulx, Sara Al-Sweidi, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Asmaa Lachhab, Martin Pelletier, Martin Pelletier, Thérèse Di Paolo, Thérèse Di Paolo, Denis Soulet, Denis Soulet, Denis Soulet   +20 more
doaj   +1 more source

Transurethral Resection of Prostate and Blood loss: Efficacy of Dutasteride in reducing perioperative blood loss.

International Journal of Endorsing Health Science Research, 2021
Background: Benign Prostatic Hyperplasia (BPH) is the most common urological cause of urinary obstruction, affecting men above 50 years of age.
Shakeel Haseeb uddin Siddique, Salman El Khalid, Muhammad Shoaib Mithani, Abdul Wasay Mahmood, Shariq Anis Khan, Fakhir Yousuf   +5 more
doaj   +1 more source

Impact of short‐term Dutasteride treatment on prostate‐specific membrane antigen expression in a mouse xenograft model

Cancer Reports, 2021
Background Dutasteride has been shown to increase expression of the prostate‐specific membrane antigen (PSMA) in prostate cancer cells in previous in vitro studies. This 5‐alpha‐reductase inhibitor is commonly used for the treatment of symptomatic benign
Benedikt Kranzbühler, Rosa Sousa, Lukas Prause, Irene A. Burger, Niels J. Rupp, Tullio Sulser, Souzan Salemi, Daniel Eberli   +7 more
doaj   +1 more source