Results 11 to 20 of about 3,490 (164)

Combined therapy with dutasteride and tadalafil vs dutasteride or tadalafil monotherapy in benign prostatic hyperplasia: a randomised phase III trial. [PDF]

BJU Int
Objectives To evaluate the efficacy and safety of a fixed‐dose combination (FDC) of dutasteride and tadalafil vs monotherapy in patients with benign prostatic hyperplasia (BPH). Patients and Methods This phase III trial enrolled 667 patients. After screening and washout, eligible patients were stratified by the baseline International Prostate Symptom ...
Lee SW, Lee SH, Kim JH, Noh JH, Lee JH, Ha US, Oh CY, Kang TW, Lee G, Lee S, Han DH, Han JH, Song SH, Park HJ, Chung BH, Min GE, Jeong IG, Moon KH, Kim WT, Lee JY, Kim CS.   +20 more
europepmc   +2 more sources

A Robust and Universal LC-MS/MS Method for Determination of N-Nitrosodimethylamine in Pharmaceuticals Using a C30 Column. [PDF]

J Sep Sci
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
An B, Kim U, Seo S, Kim J, Jeong C, Jeong W, Ko E, Kim J, Cho HD, Han SB.   +9 more
europepmc   +2 more sources

Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study

Acta Cirúrgica Brasileira, 2021
Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and ...
Marcello Henrique Araújo da Silva, João Henrique Duque Estrada, Bianca Martins Gregório, Francisco José Barcellos Sampaio, Diogo Benchimol de Souza   +4 more
doaj   +1 more source

Short course of dutasteride in treatment of a refractory category IIIB chronic prostatitis (A placebo-controlled study)

Prostate International, 2022
Objective: To evaluate the short-term efficacy of Dutasteride in the management of chronic prostatitis (CP)/chronic pelvic pain syndrome. Materials and methods: A randomized placebo-controlled double-blind study was conducted that including 50 patients ...
Ahmed Higazy, A.A. Shorbagy, Mohamed Shabayek, Ahmed Radwan, George N. Halim, Dana Osman, Tarek Osman   +6 more
doaj   +1 more source

The impact of finasteride and dutasteride treatments on proliferation, apoptosis, androgen receptor, 5α-reductase 1 and 5α-reductase 2 in TRAMP mouse prostates

Heliyon, 2017
Background: Previously, we studied the effect of finasteride- or dutasteride-containing diets in male C57BL/6 TRAMP x FVB mice. Pre (6 weeks of age) and post (12 weeks of age) groups received finasteride or dutasteride to determine the efficacy of these ...
Alexander B. Opoku-Acheampong, Jamie N. Henningson, Brian L. Lindshield   +2 more
doaj   +1 more source

Efficacy of Hair Mesotherapy With Biomimetic Peptides and Micronutrients in Patients With Androgenetic Alopecia: A Retrospective Observational Study [PDF]

J Cosmet Dermatol
ABSTRACT Background Hair mesotherapy is increasingly used in the management of androgenetic alopecia (AGA), yet standardized treatment protocols and controlled clinical data are limited. Aims This study aimed to evaluate the efficacy and safety of a mesotherapy formulation containing biomimetic peptides, vitamins, and micronutrients in patients with ...
Köse Ö, Borlu M.
europepmc   +2 more sources

The role of preoperative dutasteride in reducing bleeding during transurethral resection of the prostate: A systematic review and meta-analysis of randomized controlled trials

Asian Journal of Urology, 2022
Objective: Bleeding is one of the most common complications of transurethral resection of the prostate (TURP). Several previous studies reported that administering dutasteride before surgery could reduce perioperative bleeding.
Yudhistira Pradnyan Kloping, Niwanda Yogiswara, Yusuf Azmi   +2 more
doaj   +1 more source

Free combination of dutasteride plus tamsulosin for the treatment of benign prostatic hyperplasia in South Korea: analysis of drug utilization and adverse events using the National Health Insurance Review and Assessment Service database

BMC Urology, 2021
Objective To assess the use and safety of free combination therapy (dutasteride and tamsulosin), dutasteride monotherapy, or tamsulosin monotherapy in patients with benign prostatic hyperplasia (BPH).
Zrinka Lulic, Hwancheol Son, Sang-Bae Yoo, Marianne Cunnington, Pratiksha Kapse, Diane Miller, Vanessa Cortes, Suna Park, Rachel H. Bhak, Mei Sheng Duh   +9 more
doaj   +1 more source

Controlled release of dutasteride from biodegradable microspheres: in vitro and in vivo studies. [PDF]

PLoS ONE, 2014
The aim of the present work was to study the in vitro/in vivo characteristics of dutasteride loaded biodegradable microspheres designed for sustained release of dutasteride over four weeks.
Xiangyang Xie, Yanfang Yang, Qiang Chi, ZhiPing Li, Hui Zhang, Ying Li, Yang Yang   +6 more
doaj   +1 more source

A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride

BMC Musculoskeletal Disorders, 2018
Background Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown.
Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani, David N. Juurlink, for the Canadian Drug Safety and Effectiveness Research Network   +8 more
doaj   +1 more source