Preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice. [PDF]
PLoS ONE, 2013 BACKGROUND:The prostate cancer prevention trial (PCPT) and Reduction by dutasteride of Prostate Cancer Events (REDUCE) trial found that 5α-reductase (5αR) inhibitors finasteride and dutasteride respectively, decreased prostate cancer prevalence but also ...
Alexander B Opoku-Acheampong +4 more
doaj +1 more source
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
Acta Cirúrgica Brasileira, 2021 Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and ...
Marcello Henrique Araújo da Silva +4 more
doaj +1 more source
Metastatic Prostate Cancer Masquerading as Locally Advanced Breast Cancer. [PDF]
Clin Case RepABSTRACT We report a rare case of a 72‐year‐old man with prostatic adenocarcinoma metastasizing to gynecomastia breast tissue with ipsilateral axillary lymph node involvement. This presentation is notable for the absence of disseminated metastatic disease or prolonged androgen deprivation therapy.
Howard T +5 more
europepmc +2 more sources
Prostate International, 2022 Objective: To evaluate the short-term efficacy of Dutasteride in the management of chronic prostatitis (CP)/chronic pelvic pain syndrome. Materials and methods: A randomized placebo-controlled double-blind study was conducted that including 50 patients ...
Ahmed Higazy +6 more
doaj +1 more source
Short-term pretreatment with a dual 5α-reductase inhibitor before bipolar transurethral resection of the prostate (b-turp): evaluation of prostate vascularity and decreased surgical blood loss in large prostates [PDF]
, 2015 Objective: To investigate if short-term treatment with dutasteride (8 weeks) before bipolar transurethral resection of the prostate (B-TURP) can reduce intraoperative bleeding, as dutasteride a dual 5α-reductase inhibitor (5-ARI) blocks the conversion of
Amory +28 more
core +1 more source
Single-nucleotide polymorphism-based genetic risk score and patient age at prostate cancer diagnosis [PDF]
, 2019 Importance: Few studies have evaluated the association between a single-nucleotide polymorphism-based genetic risk score (GRS) and patient age at prostate cancer (PCa) diagnosis.
Andriole, Gerald L +10 more
core +2 more sources
Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation [PDF]
, 2011 Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons.
Izumi, Yukitoshi +2 more
core +2 more sources
Heliyon, 2017 Background: Previously, we studied the effect of finasteride- or dutasteride-containing diets in male C57BL/6 TRAMP x FVB mice. Pre (6 weeks of age) and post (12 weeks of age) groups received finasteride or dutasteride to determine the efficacy of these ...
Alexander B. Opoku-Acheampong +2 more
doaj +1 more source
Asian Journal of Urology, 2022 Objective: Bleeding is one of the most common complications of transurethral resection of the prostate (TURP). Several previous studies reported that administering dutasteride before surgery could reduce perioperative bleeding.
Yudhistira Pradnyan Kloping +2 more
doaj +1 more source
Dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: Results from the randomised, placebo-controlled avodart after radical therapy for Prostate Cancer Study (ARTS) [PDF]
, 2013 Background: Rising prostate-specific antigen (PSA) levels after radical therapy are indicative of recurrent or residual prostate cancer (PCa). This biochemical recurrence typically predates clinically detectable metastatic disease by several years ...
Alcaraz, A. (Antonio) +8 more
core +1 more source