Results 41 to 50 of about 6,946 (216)

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man [PDF]

, 2015
Context: 5α-Reductase 1 and 2 (SRD5A1, SRD5A2) inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of DHT. Dutasteride (dual SRD5A1 and SRD5A2 inhibitor) and finasteride (selective SRD5A2 inhibitor) are commonly ...
Armstrong, M. J., Davies, N. P., Di Guida, R., Dunn, W. B., Flintham, R. B., Grinbergs, A. E. K., Hazlehurst, J. M., Hodson, L., Hughes, B. A., Nikolaou, N., Oprescu, A. I., Taylor, A. E., Tomlinson, J. W., Yu, J.   +13 more
core   +2 more sources

Contact Sensitization in Patients With Frontal Fibrosing Alopecia: Patch Test Results With an Extended Baseline Series in Consecutive Patients

Contact Dermatitis, EarlyView.
Sensitization to propolis, shellac and gallate mix is FFA‐associated, but its relevance is largely unknown. Sensitization to salicylates is frequent and associated with symptoms of intolerance to sun exposure or sunscreens. No significant improvement by allergen avoidance is identified.
María‐Antonia Pastor‐Nieto, María Elena Gatica Ortega, Anna María Giménez‐Arnau, Tatiana Sanz‐Sánchez, Pedro Mercader García, Inmaculada Ruíz‐González, Gemma Melé‐Ninot, Pablo Chicharro, Paloma Sánchez‐Pedreño, Marina de Vega, Miguel Ángel Gallego Descalzo, Leopoldo Borrego   +11 more
wiley   +1 more source

Effect of dutasteride treatment on reducing blood loss and in perioperative period of open prostatectomy

Urology Research and Practice, 2019
Objective: Open prostatectomy (OP) is a valid option for the surgical treatment of large prostates in the absence of holmium laser enucleation. The most frequent complication of OP is intra- and perioperative bleeding. Preoperative use of dutasteride has
Mehmet İlker Gökçe, Seymur Kerimov, Aykut Akıncı, Nurullah Hamidi, Faraj Afandiyev, Önder Yaman   +5 more
doaj   +1 more source

Role of dutasteride in pre‐clinical ETS fusion‐positive prostate cancer models [PDF]

, 2012
BACKGROUND Androgens play a crucial role in prostate cancer, hence the androgenic pathway has become an important target of therapeutic intervention.
Ateeq, Bushra, Cao, Qi, Lonigro, Robert J., Pienta, Kenneth J., Tomlins, Scott A., Varambally, Sooryanarayana, Vellaichamy, Adaikkalam, Wang, Rui   +7 more
core   +1 more source

The influence of age and the presence of prostate cancer on prostate volume, PSA and PSA density

BJU International, Volume 137, Issue 5, Page 805-812, May 2026.
Objective To assess prostate volume (PV) changes with age in symptomatic and asymptomatic men with and without clinically significant prostate cancer (csPCa). In symptomatic patients, we additionally analysed the effect of age and csPCa on PSA and PSA‐density (PSA‐D) and compared these to current National Institute for Health and Care Excellence (NICE)
Jill Rusbridge, Iztok Caglic, Liness Thavaraja, Nikita Sushentsev, Tristan Barrett   +4 more
wiley   +1 more source

Baseline characteristics predict risk of progression and response to combined medical therapy for benign prostatic hyperplasia (BPH) [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110594/1/bju12802 ...
Anderson, Barry, Barry, Burke, Crawford, Cuticchia, D'Agostino, Dorresteijn, Emberton, Flanigan, Hong, Jacobsen, Kaplan, Kent, Kok, Lowe, Martin, Maserejian, McConnell, Parsons, Roehrborn, Roehrborn, Roehrborn, Roehrborn, Slawin, Slawin, Steyerberg, Trachtenberg   +27 more
core   +1 more source

THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT

Jurnal Urologi Indonesia, 2017
Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF ...
Andry Irawan, Ignatius Riwanto, Eriawan Agung Nugroho   +2 more
doaj   +1 more source

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. [PDF]

, 2019
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in ...
Arnold, Frederick J., Merry, Diane E., Pluciennik, Anna   +2 more
core   +3 more sources

Targeted Molecular Therapies for SBMA [PDF]

, 2015
Spinal and bulbar muscular atrophy (SBMA) is a late-onset neuromuscular disease caused by a polyglutamine expansion in the androgen receptor gene which results in progressive spinal and bulbar motor neuron degeneration, and muscle atrophy.
Greensmith, L, Malik, B, Rinaldi, C
core   +1 more source

Evaluating the Effectiveness of Commercial Oral Supplements for Hair Growth: A Systematic Review and Meta‐Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Hair loss is a common condition affecting both men and women, with significant psychosocial impact. While oral supplements are marketed to improve hair growth, their clinical efficacy remains debated. This systematic review aimed to evaluate the effectiveness and safety of commercial oral nutraceuticals for hair growth.
Razan Alanazi, Shadan Alshammari, Kadi Aldossari, Raneem Alwatban, Deema Aljeribah, Shoog Alanazi, Abdulaziz Alsalhi, Aminah Alhumam, Abdulmajeed Alajlan   +8 more
wiley   +1 more source