Results 41 to 50 of about 4,151 (165)

Arachis hypogaea L. Root Extract Mitigates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in ICR Mice by Suppressing Inflammation, Androgen Receptors, and Dihydrotestosterone

open access: yesFood Science &Nutrition, Volume 14, Issue 3, March 2026.
In summary this study evaluated the protective effects of Arachis hypogaea L. root extract (AHRE) against testosterone propionate (TP)‐induced benign prostatic hyperplasia (BPH) in ICR mice. AHRE was prepared and administered in varying doses (100, 200, 300 mg/kg BW) alongside TP, with finasteride as a positive control.
Samee‐Ullah   +9 more
wiley   +1 more source

The role of 5‐alpha reductase inhibitors in transurethral resection of the prostate: a meta‐analysis of randomised controlled trials

open access: yesBJU International, Volume 137, Issue 3, Page 430-443, March 2026.
Objective To critically evaluate the existing evidence base surrounding the efficacy of preoperative 5‐alpha reductase inhibitor (5ARI) administration in the reduction of perioperative complication rates in transurethral resection of prostate (TURP). Methods In April 2025, a systematic search of on‐line databases was conducted to identify randomised ...
Cian M. Hehir   +5 more
wiley   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

open access: yesAdvanced Science, Volume 13, Issue 11, 23 February 2026.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang   +12 more
wiley   +1 more source

Dihydrotestosterone and Finasteride Effects on Alcohol Cue‐Elicited Brain Activity in Males With Heavy Episodic Drinking

open access: yesAddiction Biology, Volume 31, Issue 2, February 2026.
In a randomized, double‐blind, placebo‐controlled crossover study, we investigated whether finasteride‐induced reduction of dihydrotestosterone alters alcohol cue‐elicited brain activity and craving in males with heavy episodic drinking. Although dihydrotestosterone concentrations were not associated with neural cue reactivity, finasteride increased ...
Rafat Boroumand‐Jazi   +15 more
wiley   +1 more source

Prostate zonal impact of 5α‐reductase inhibitors on multiparametric MRI characteristics and detection of prostate cancer

open access: yesBJU International, Volume 137, Issue 2, Page 332-338, February 2026.
Objectives To assess the impact of 5α‐reductase inhibitors (5‐ARIs) on multiparametric magnetic resonance imaging (mpMRI) features of Prostate Imaging‐Reporting and Data System (PI‐RADS) lesions and their influence on the detection of clinically significant prostate cancer (csPCa), with a focus on differences between prostate zones.
Arighno Das   +12 more
wiley   +1 more source

การศึกษาประสิทธิศักย์และความปลอดภัยของการใช้ยา dutasteride ขนาดต่ำ ในการรักษาภาวะผมบางจากพันธุกรรมในเพศชาย [PDF]

open access: yes
Currently, finasteride 1 mg/day is the first-line treatment that gives non-improved results in some men with androgenetic alopecia. Dutasteride, in the same drug class, and a dual inhibitor of 5a-reductase, can be used as an alternative. Previous studies

core  

Statement from the frontal fibrosing alopecia international expert alliance: SOFFIA 2024

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 210-223, February 2026.
Optimal treatment for frontal fibrosing alopecia (FFA) remains contentious. An international expert panel agreed that highly/ultra‐potent topical steroids were the preferred first‐line topical therapy. Preferred systemic therapies were 5‐alpha reductase inhibitors, followed by hydroxychloroquine.
Nekma Meah   +64 more
wiley   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

open access: yesMolecular Oncology, Volume 20, Issue 1, Page 117-133, January 2026.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat   +18 more
wiley   +1 more source

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis

open access: yes, 2019
Zhongbao Zhou,1,2,* Shiqiang Song,3,* Zhenli Gao,2 Jitao Wu,2 Jiajia Ma,2 Yuanshan Cui2 1School of clinical medicine, Binzhou Medical University, Yantai, Shandong, China; 2Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao ...
Wu J, Cui Y, Song S, Gao Z, Ma J, Zhou Z
core  

Scanning electron micrographs of dutasteride loaded PLGA microspheres.

open access: yes, 2014
Scanning electron micrographs of dutasteride loaded PLGA microspheres.
Yanfang Yang (408813)   +6 more
core   +1 more source

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