Fluorescent Azasteroids through Ultrasound Assisted Cycloaddition Reactions [PDF]
Molecules, 2021 We report here the synthesis and optical spectral properties of several new azasteroid derivatives. The formation of these compounds was explained based on the most probable mechanism.
Costel Moldoveanu +2 more
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A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria. [PDF]
ACS Infect Dis, 2023 By illuminating key 6-azasteroid–protein interactions in both Mycobacterium tuberculosis (Mtb) and the closely related model organism Mycobacterium marinum (Mm), we sought to improve the antimycobacterial potency of 6-azasteroids and further our ...
Werman JM +4 more
europepmc +3 more sources
Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro [PDF]
Microbiology SpectrumAlthough the current multidrug therapy (MDT) for leprosy is very successful, the long treatment duration and the emergence of antibiotic-resistant strains demand for new alternative drugs.
Thabatta L. S. A. Rosa +13 more
doaj +3 more sources
Inhibition of Phytosterol Biosynthesis by Azasterols [PDF]
Molecules, 2020 Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet +5 more
doaj +4 more sources
Inhibition of the M. tuberculosis 3β-hydroxysteroid dehydrogenase by azasteroids. [PDF]
Bioorg Med Chem Lett, 2011 The cholesterol metabolism pathway in Mycobacterium tuberculosis (M. tb) is a potential source of energy as well as secondary metabolite production that is important for survival of M. tb in the host macrophage.
Thomas ST, Yang X, Sampson NS.
europepmc +3 more sources
5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis [PDF]
Cancer Cell International, 2012 Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments.
Kapp Friedrich G +4 more
doaj +4 more sources
Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids [PDF]
Steroids, 2012 19-Hydroxy-6-azapregnanes were obtained from pregnenolone via a 7-azido-5-oxo-6-nor-5,7-secopregnane intermediate. The 6-azapregnane core was built in good yield in a straightforward way from the secosteroid, by means of a Staudinger (aza-Wittig ...
Mario D. Martínez +4 more
semanticscholar +4 more sources
Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies [PDF]
Molecules, 2022 A series of novel 21E-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines.
Vanessa Brito +4 more
doaj +2 more sources
Synthesis and biological testing for pesticidal activity of 8-azasteroids
Proceedings of Universities. Applied Chemistry and Biotechnology, 2022 The aim of the present study is the synthesis and testing for pesticidal activities of 2,3-dimethoxy16,16-dimethyl-D-homo-8-azagona-1,3,5(10),13-tetraene-12,17а-one and 2,3-dimethoxy-16,16-dimethyl-dhomo-8-azagona-1,3,5(10),13-tetraene-12-imino-17а-one ...
A. N. Pyrko
openalex +3 more sources
The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. [PDF]
Adv Urol, 2012 Despite the discovery of 5 alpha‐reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha‐reduced steroids in human diseases was not appreciated until the discovery of 5 alpha‐reductase type 2 deficiency in 1974. Affected males are born
Azzouni F, Godoy A, Li Y, Mohler J.
europepmc +2 more sources