Results 1 to 10 of about 449 (133)

Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro [PDF]

Microbiology Spectrum
Although the current multidrug therapy (MDT) for leprosy is very successful, the long treatment duration and the emergence of antibiotic-resistant strains demand for new alternative drugs.
Ramanuj Lahiri, Daniele Bertoluci, John Belisle   +2 more
exaly   +4 more sources

Fluorescent Azasteroids through Ultrasound Assisted Cycloaddition Reactions [PDF]

Molecules, 2021
We report here the synthesis and optical spectral properties of several new azasteroid derivatives. The formation of these compounds was explained based on the most probable mechanism.
Costel Moldoveanu, Ionel Mangalagiu, Gheorghita Zbancioc   +2 more
doaj   +2 more sources

Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies [PDF]

Molecules, 2022
A series of novel 21E-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines.
Vanessa Brito, Adriana Oliveira Santos, Gilberto Alves, Paulo Almeida, Samuel Silvestre   +4 more
doaj   +2 more sources

Inhibition of Phytosterol Biosynthesis by Azasterols [PDF]

Molecules, 2020
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet, Laetitia B B Martin, Pierre Mercier, Franz Bracher, Philippe Geoffroy, Hubert Schaller   +5 more
doaj   +2 more sources

The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. [PDF]

Adv Urol, 2012
Despite the discovery of 5 alpha‐reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha‐reduced steroids in human diseases was not appreciated until the discovery of 5 alpha‐reductase type 2 deficiency in 1974. Affected males are born
Azzouni F, Godoy A, Li Y, Mohler J.
europepmc   +2 more sources

5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis [PDF]

Cancer Cell International, 2012
Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments.
Kapp Friedrich G, Sommer Anette, Kiefer Thomas, Dölken Gottfried, Haendler Bernard   +4 more
doaj   +2 more sources

Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group [PDF]

Journal of the Serbian Chemical Society, 2004
In the present paper, the preparation of 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3β-yl acetate (1)1,2 was used as the starting material, which was transformed to the key ...
Pavlović Vladimir D., Dabović Milan M., Martinović Saša, Lorenc Ljubinka B., Kalvoda Jaroslav   +4 more
doaj   +1 more source

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Clinical and Translational Medicine, Volume 10, Issue 8, December 2020., 2020
Schematic representation of cause, exacerbation and consequence of vaccines‐induced diverse immune disorders in immune‐responsive or immune‐privileged tissues. It depicts that vaccination of the unborn, alter biology of trophoblast‐embryo‐fetus‐placenta and orderly growth and development affecting epithelial‐mesenchymal transition, proper expression of
Mahin Khatami
wiley   +1 more source

Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N‐2′‐Hydroxyethyl‐Substituted Azacholestanes Prepared from 6‐Oxocholestanes by Modified Schmidt Reaction

Journal of Spectroscopy, Volume 2013, Issue 1, 2013., 2013
The present paper reports the synthesis and spectroscopic characterization of few N‐2′‐hydroxyethyl‐substituted azacholestanes using BF3‐OEt2, TiCl4, SnCl4, and H2SO4 as catalysts in moderate yields by a modified version of Schmidt reaction. A notable feature is the passivity of SnCl4 in case of 3β‐acetoxy‐N‐2′‐hydroxyethyl‐6‐aza‐B‐homo‐5α‐cholestan‐7 ...
Shahab A. A. Nami, Suraiya Khan, Mahboob Alam, M. Mushfiq, Dong-Ung Lee, Soonheum Park, Mircea Cotlet   +6 more
wiley   +1 more source

19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 2. X-ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids [PDF]

Journal of Medicinal Chemistry, 1997
19-Nor-10-azasteroids are a new class of 5 alpha-reductase inhibitors whose activity depends on the presence of the bridgehead N-10 atom conjugated with the 4-en-3-one moiety in the A ring. The X-ray structure of 19-nor-10-azasteroid 1 has been determined and it is compared with the X-ray structure of testosterone. A complete conformational analysis of
GUARNA, ANTONIO, OCCHIATO, ERNESTO GIOVANNI, MACHETTI, FABRIZIO, DANZA, GIOVANNA, SERIO, MARIO, PAOLI, PAOLA, A. MARRUCCI   +6 more
openaire   +4 more sources