Fluorescent Azasteroids through Ultrasound Assisted Cycloaddition Reactions [PDF]
Molecules, 2021 We report here the synthesis and optical spectral properties of several new azasteroid derivatives. The formation of these compounds was explained based on the most probable mechanism.
Costel Moldoveanu +2 more
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5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis [PDF]
Cancer Cell International, 2012 Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments.
Kapp Friedrich G +4 more
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The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. [PDF]
Adv Urol, 2012 Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not ...
Azzouni F, Godoy A, Li Y, Mohler J.
europepmc +4 more sources
Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies [PDF]
Molecules, 2022 A series of novel 21E-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines.
Vanessa Brito +4 more
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Inhibition of Phytosterol Biosynthesis by Azasterols [PDF]
Molecules, 2020 Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet +5 more
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Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro [PDF]
Microbiology SpectrumAlthough the current multidrug therapy (MDT) for leprosy is very successful, the long treatment duration and the emergence of antibiotic-resistant strains demand for new alternative drugs.
Thabatta L. S. A. Rosa +13 more
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Steroid diversification by multicomponent reactions. [PDF]
Beilstein J Org Chem, 2019 Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of steroidal substrates in MCRs ...
Reguera L +3 more
europepmc +3 more sources
Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group [PDF]
Journal of the Serbian Chemical Society, 2004 In the present paper, the preparation of 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3β-yl acetate (1)1,2 was used as the starting material, which was transformed to the key ...
Pavlović Vladimir D. +4 more
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SAR Analysis of Small Molecules Interfering with Energy-Metabolism in Mycobacterium tuberculosis. [PDF]
Pharmaceuticals (Basel), 2020 Tuberculosis remains the world’s top infectious killer: it caused a total of 1.5 million deaths and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality has been falling in recent years, with an estimated 58 million
Appetecchia F +4 more
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19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 2. X-ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids [PDF]
Journal of Medicinal Chemistry, 1997 19-Nor-10-azasteroids are a new class of 5 alpha-reductase inhibitors whose activity depends on the presence of the bridgehead N-10 atom conjugated with the 4-en-3-one moiety in the A ring. The X-ray structure of 19-nor-10-azasteroid 1 has been determined and it is compared with the X-ray structure of testosterone. A complete conformational analysis of
Antonio Guarna +2 more
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