Results 41 to 50 of about 1,295 (195)
Synthesis of Indolizidine Azasteroids
HETEROCYCLES, 1981 Jacek W. Morzycki, W. J. RODEWALD
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, 2016 19-Nor-10-azasteroids are a new class of 5α-reductase inhibitors whose activity depends on the presence of the bridgehead N-10 atom conjugated with the 4-en-3-one moiety in the A ring. The X-ray structure of 19-nor-10-azasteroid 1 has been determined and
Ernesto G. Occhiato (1892020) +6 more
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Synthesis of 4-azasteroids by an intramolecular Ugi reaction
Steroids, 2008 In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely substituted both at N-4 and C-5. Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reaction.
Fernando Alonso +3 more
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Synthesis of 5-azaandrostane-3b,17b-diol protected at the 17b-hydroxyl group [PDF]
Journal of the Serbian Chemical Society, 2004 In the present paper, the preparation of 3b-hydroxy-17b-dimethyl-tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3b-yl acetate (1) was used as the starting material, which was transformed to the key ...
JAROSLAV KALVODA +4 more
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, 2016 A one-pot, mild, two-component iminium ion–enamine cascade reaction to construct structurally diverse azacyclic frameworks from l-proline and l-pipecolic acid, and its application to indolizidine and quinolizidine alkaloids and azasteroids, is ...
Amit Kumar Chattopadhyay (1672132) +1 more
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, 2016 A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in ...
Azriel Schmidt (2356921) +16 more
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Studies on The Synthesis of B-Ring 6-Azasteroids [PDF]
, 2006 Azasteroids, which carry a nitrogen in the C-6 position of the steroid nucleus are still mysterious and very few synthesized, were found to possess antimicrobial and antifungal properties apart from their pharmacodynamic actions. The literature reports
Gandikota, Jyothi
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3D-QSAR and virtual screening of 5α-reductase Ⅱ inhibitors of 6-azasteroids
四川大学学报. 自然科学版, 2018 Three-dimensional quantitative structure-activity relationship analysis of 37 6-azasteroids inhibitors was carried out by Topomer CoMFA. The new model’s cross validation and correlation coefficient were q2=0.774 and r2=0.965, respectively.
LIU Hua +4 more
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, 2007 Many naturally extracted guaianolides (i.e. GLs) and pseudoguaianolides are based on the 5,7,5-fused ring skeleton and they show a broad biological profile. Among them, Arglabin has attracted special attention due to its promising antitumor and cytotoxic
Jeong, Won Boo
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