Results 21 to 30 of about 449 (133)
Studies on The Synthesis of B-Ring 6-Azasteroids [PDF]
, 2006 Azasteroids, which carry a nitrogen in the C-6 position of the steroid nucleus are still mysterious and very few synthesized, were found to possess antimicrobial and antifungal properties apart from their pharmacodynamic actions. The literature reports
Gandikota, Jyothi
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Asymmetric methodologies for the construction of 5,7,5- and 6,6,6-tricyclic sesquiterpene lactones towards the synthesis of Arglabin [PDF]
, 2007 Many naturally extracted guaianolides (i.e. GLs) and pseudoguaianolides are based on the 5,7,5-fused ring skeleton and they show a broad biological profile. Among them, Arglabin has attracted special attention due to its promising antitumor and cytotoxic
Jeong, Won Boo
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Synthetic routes to azasteroids and cyclic amidines using aza diels-alder reactions
, 2000 Azasteroids exhibit a wide range of biological activity and hence the search for successful synthetic routes and novel azasteroid structures is of considerable scientific interest.
Rataj, Helen
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EFFECT OF ORALLY ADMINISTERED AZASTEROIDS ON IMPLANTATION IN RATS [PDF]
Reproduction, 1969 Summary. Nine azasteroids have been evaluated for antifertility effect in rats when fed orally from Days 1 to 4 of pregnancy at the dose of 10 mg/kg body weight. The compounds 3β-hydroxy-androst-5-ene (16, 17-C)-5-methyl-pyrazole and 1,2,3,4-tetrahydro-N-tosyl-8-methoxy-4-oxo-benzo(b)quinoline inhibited pregnancy at that dose in a ...
S K, Saksena, R R, Chaudhury
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, 2016 A one-pot, mild, two-component iminium ion–enamine cascade reaction to construct structurally diverse azacyclic frameworks from l-proline and l-pipecolic acid, and its application to indolizidine and quinolizidine alkaloids and azasteroids, is ...
Amit Kumar Chattopadhyay (1672132) +1 more
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By illuminating key 6-azasteroid–protein interactions in both Mycobacterium tuberculosis (Mtb) and the closely related model organism Mycobacterium marinum (Mm), we sought to improve the antimycobacterial potency of 6-azasteroids and further our ...
Joshua M. Werman (17069649) +4 more
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, 2016 A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in ...
Azriel Schmidt (2356921) +16 more
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A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria. [PDF]
ACS Infect Dis, 2023 Werman JM +4 more
europepmc +1 more source
19-Nor-10-azasteroids: A Novel Class of Inhibitors for Human Steroid 5?-Reductases 1 and 2
, 1997 Steroid 5 alpha-reductase is a system of two isozymes (5 alpha R-1 and 5 alpha R-2) which catalyzes the NADPH-dependent reduction of testosterone to dihydrotestosterone in many androgen sensitive tissues and which is related to several human endocrine ...
Guarna Antonio +10 more
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Syntheses and antimicrobial activities of some 4-aza-sitostane derivatives [PDF]
, 1969 Research into the chemical and pharmacological properties of azasteroids has become of interest because of their potential value as pharmacodynamic and chemotherapeutic agents. A nitrogen atom, for example, would be able to interact, unlike carbon, with
Aboul-Enein, Hassan Y.
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