Results 31 to 40 of about 1,295 (195)
6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase
Journal of Medicinal Chemistry, 1993 Stephen V. Frye +8 more
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Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group [PDF]
Journal of the Serbian Chemical Society, 2004 In the present paper, the preparation of 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3β-yl acetate (1)1,2 was used as the starting material, which was transformed to the key ...
Pavlović Vladimir D. +4 more
doaj +1 more source
EFFECT OF ORALLY ADMINISTERED AZASTEROIDS ON IMPLANTATION IN RATS [PDF]
Reproduction, 1969 Summary. Nine azasteroids have been evaluated for antifertility effect in rats when fed orally from Days 1 to 4 of pregnancy at the dose of 10 mg/kg body weight. The compounds 3β-hydroxy-androst-5-ene (16, 17-C)-5-methyl-pyrazole and 1,2,3,4-tetrahydro-N-tosyl-8-methoxy-4-oxo-benzo(b)quinoline inhibited pregnancy at that dose in a ...
Seema Saksena, Ranjit Roy Chaudhury
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Clinical and Translational Medicine, Volume 10, Issue 8, December 2020., 2020 Schematic representation of cause, exacerbation and consequence of vaccines‐induced diverse immune disorders in immune‐responsive or immune‐privileged tissues. It depicts that vaccination of the unborn, alter biology of trophoblast‐embryo‐fetus‐placenta and orderly growth and development affecting epithelial‐mesenchymal transition, proper expression of
Mahin Khatami
wiley +1 more source
Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities. [PDF]
ACS Infect Dis, 2019 One-third of the world’s population carries Mycobacterium tuberculosis (Mtb), the infectious agent that causes tuberculosis (TB), and every 17 s someone dies of TB.
Yang X +10 more
europepmc +2 more sources
Effect of Azasteroids on Gram-Positive Bacteria [PDF]
Journal of Bacteriology, 1967 A group of nitrogen-containing steroids closely related in structure was screened for antibacterial activity, by use of Bacillus subtilis and Sarcina lutea as the test organisms. The most active compounds were cholesterol derivatives containing a tertiary or quaternary nitrogen in, or ...
Frederick Varricchio +2 more
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Acyl radical cascade reactions: the synthesis of azasteroids [PDF]
, 1998 Our work has been concerned with the synthesis of azasteroid ring systems, utilising acyl radical cascade reactions. Chapter 1 comprises an overview of published work relevant to our studies: an analysis of steroid biosynthesis and synthesis; a review of
Philip Double
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Journal of Spectroscopy, Volume 2013, Issue 1, 2013., 2013 The present paper reports the synthesis and spectroscopic characterization of few N‐2′‐hydroxyethyl‐substituted azacholestanes using BF3‐OEt2, TiCl4, SnCl4, and H2SO4 as catalysts in moderate yields by a modified version of Schmidt reaction. A notable feature is the passivity of SnCl4 in case of 3β‐acetoxy‐N‐2′‐hydroxyethyl‐6‐aza‐B‐homo‐5α‐cholestan‐7 ...
Shahab A. A. Nami +6 more
wiley +1 more source
A general synthesis of 6-azasteroids
, 2012 The ozonization of 7-ketocholesteryl acetate has yielded 5-keto-5, 7-seco-6-nor-3-cholesten-7-oic acid, an intermediate useful in the preparation of 6-azacholestane. Catalytic hydrogenation converted this intermediate to 5-keto-5,7-seco-6-norcholestan-7-oic acid which, upon treatment with benzyl amine, gave N-benzyl-6-aza-4-cholesten-7-one.
Roy A. Johnson
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