Results 31 to 40 of about 449 (133)

Synthesis of 4-azasteroids by an intramolecular Ugi reaction

Steroids, 2008
In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely substituted both at N-4 and C-5. Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reaction.
Alonso, Fernando, Acebedo, Sofía Lorena, Bruttomesso, Andrea, Ramirez, Javier Alberto   +3 more
openaire   +3 more sources

The Mce3R Regulon Is Required for 6-Azasteroid Potentiation of Anti-TB Drug Activity

, 2018
Cholesterol is important for Mycobacterium tuberculosis (Mtb) survival and persistence in the host. We describe a series of 6-azasteroids tested as cholesterol analogs, that are synergistic inhibitors of Mtb viability.
Xinxin Yang, Rui Ma, Tianao Yuan, Scott Franzblau, Nicole Sampson   +4 more
core   +1 more source

Skeletal metalation of lactams through a carbonyl-to-nickel-exchange logic. [PDF]

Nat Commun, 2023
Zhong H, Egger DT, Gasser VCM, Finkelstein P, Keim L, Seidel MZ, Trapp N, Morandi B.   +7 more
europepmc   +1 more source

Azoarene activation for Schmidt-type reaction and mechanistic insights. [PDF]

Nat Commun, 2022
Meng FT, Wang YN, Qin XY, Li SJ, Li J, Hao WJ, Tu SJ, Lan Y, Jiang B.   +8 more
europepmc   +1 more source

Synthesis and reactions of 4-azasteroidal alkylating agents: approaches to related 5-azasteroids

, 1986
Bibliography: p. 178-203.
openaire   +2 more sources

The Effect of Long-Term Tamsulosin Monotherapy and Tamsulosin - Dutasteride Combination Therapy on PKC-α Enzyme Expression in Prostate Stromal Tissue. [PDF]

Med Arch, 2023
Daryanto B, Purnomo AF, Patriawan YS, Purnomo BB.   +3 more
europepmc   +1 more source

Characteristics of prostate biopsy in patients under the dutasteride treatment. [PDF]

Medicine (Baltimore), 2022
Obinata D, Nakahara K, Yoshizawa T, Mochida J, Yamaguchi K, Takahashi S.   +5 more
europepmc   +1 more source

The Effect of Tamsulosin, Dutasteride Monotherapy and Tamsulosin-Dutasteride Combination on Prostate Smooth Muscle Contractility in BPH Model Wistar Strain Rattus Novergicus. [PDF]

Med Arch, 2023
Daryanto B, Naim HY, Budaya TN.
europepmc   +1 more source

A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

, 2016
In a drug reprofiling attempt, we explored novel neuroprotective properties of 4-azasteroids by synthesizing chemical affinity tags capturing adenine nucleotide translocator-1, as a potential target. Dutasteride inhibits the mitochondrial transition pore
Slobodan Poznanović (2436160), Martina Klemm (2436172), Gerhard P. Schwall (2436166), Rainer Schoepf (2436163), André Schrattenholz (2254882), Werner Stegmann (2254873), Karlfried Groebe (2254876), Michael Burnet (1459333), Vukić Šoškić (2436169), Helmut Zengerling (2254903), Tassula Proikas-Cezanne (252759)   +10 more
core   +1 more source

Effects of Curcumin Combined With the 5-alpha Reductase Inhibitor Dutasteride on LNCaP Prostate Cancer Cells. [PDF]

In Vivo, 2021
Nakayama A, Ide H, Lu Y, Takei A, Fukuda K, Osaka A, Arai G, Horie S, Okada H, Saito K.   +9 more
europepmc   +1 more source