Results 51 to 60 of about 1,295 (195)
By illuminating key 6-azasteroid–protein interactions in both Mycobacterium tuberculosis (Mtb) and the closely related model organism Mycobacterium marinum (Mm), we sought to improve the antimycobacterial potency of 6-azasteroids and further our ...
Joshua M. Werman (17069649) +4 more
core +1 more source
, 2016 In a drug reprofiling attempt, we explored novel neuroprotective properties of 4-azasteroids by synthesizing chemical affinity tags capturing adenine nucleotide translocator-1, as a potential target. Dutasteride inhibits the mitochondrial transition pore
Slobodan Poznanović (2436160) +10 more
core +1 more source
Synthetic routes to azasteroids and cyclic amidines using aza diels-alder reactions
, 2000 Azasteroids exhibit a wide range of biological activity and hence the search for successful synthetic routes and novel azasteroid structures is of considerable scientific interest.
Rataj, Helen
core
Synthesis and reactions of 4-azasteroidal alkylating agents: approaches to related 5-azasteroids
, 1986 Bibliography: p. 178-203.
openaire +2 more sources
Studies on the synthesis of monoterpene alkaloids and related compounds [PDF]
, 1966 The chemistry of monoterpene alkaloids is reviewed, and a brief review of the chemistry of 9-azasteroids is given. The attempted synthesis of an alkaloid thought to be 6,7-dihydro-7-methyl-5H-2-pyrindine is described. Several methods for the construction
core
Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes [PDF]
, 2011 Sujeong Kim, Yong‐ung Kim, Eunsook Ma
openalex +1 more source
Syntheses and antimicrobial activities of some 4-aza-sitostane derivatives
, 1969 Research into the chemical and pharmacological properties of azasteroids has become of interest because of their potential value as pharmacodynamic and chemotherapeutic agents. A nitrogen atom, for example, would be able to interact, unlike carbon, with
Aboul-Enein, Hassan Y.
core
Skeletal metalation of lactams through a carbonyl-to-nickel-exchange logic. [PDF]
Nat Commun, 2023 Zhong H +7 more
europepmc +1 more source
, 2019 One-third of the world’s population carries Mycobacterium tuberculosis (Mtb), the infectious agent that causes tuberculosis (TB), and every 17 seconds someone dies of TB.
Harm, van Bakel +10 more
core +2 more sources
Azoarene activation for Schmidt-type reaction and mechanistic insights. [PDF]
Nat Commun, 2022 Meng FT +8 more
europepmc +1 more source