Results 11 to 20 of about 449 (133)
Synthetic approaches to 9-azasteroids [PDF]
, 1968 An account is given of total syntheses of azasteroids, syntheses of 4-piperidones, and also syntheses of 2-quinolizidones. \ud l,2,3,4,5,6-Hexahydro-3-oxo-4aH-benzo[c]quinolizine was prepared and methylation shown to occur in the 2-position which was of no further synthetic value.
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Synthetic routes to 9-azasteroids [PDF]
, 1975 Syntheses of azasteroids both from natural steroids and from precursors bearing a nitrogen atom are reviewed.\ud The present research was directed towards the preparation of suitable tricyclic compounds possessing the future A-,B- and D-rings of a 9-azasteroid system which were suitably substituted for the construction of ring C of the azasteroid ...
Easom, John MM
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Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones [PDF]
, 2016 Steroids are one of the essential classes of bioactive compounds and are involved in many biological functions which include their role as signaling compounds, the alteration of membrane fluidity and the regulation of a variety of metabolic processes. In
Birudukota, Nagaraju
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, 2016 19-Nor-10-azasteroids are a new class of 5α-reductase inhibitors whose activity depends on the presence of the bridgehead N-10 atom conjugated with the 4-en-3-one moiety in the A ring. The X-ray structure of 19-nor-10-azasteroid 1 has been determined and
Ernesto G. Occhiato (1892020) +6 more
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Synthesis of 5-azaandrostane-3b,17b-diol protected at the 17b-hydroxyl group [PDF]
Journal of the Serbian Chemical Society, 2004 In the present paper, the preparation of 3b-hydroxy-17b-dimethyl-tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3b-yl acetate (1) was used as the starting material, which was transformed to the key ...
JAROSLAV KALVODA +4 more
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Acyl radical cascade reactions: the synthesis of azasteroids [PDF]
, 1998 Our work has been concerned with the synthesis of azasteroid ring systems, utilising acyl radical cascade reactions. Chapter 1 comprises an overview of published work relevant to our studies: an analysis of steroid biosynthesis and synthesis; a review of
Double, Philip John
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Acyl radical cascade reactions: the synthesis of azasteroids [PDF]
Our work has been concerned with the synthesis of azasteroid ring systems, utilising acyl radical cascade reactions. Chapter 1 comprises an overview of published work relevant to our studies: an analysis of steroid biosynthesis and synthesis; a review of
Double, Philip John
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Studies on the synthesis of monoterpene alkaloids and related compounds [PDF]
, 1966 The chemistry of monoterpene alkaloids is reviewed, and a brief review of the chemistry of 9-azasteroids is given. The attempted synthesis of an alkaloid thought to be 6,7-dihydro-7-methyl-5H-2-pyrindine is described. Several methods for the construction
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3D-QSAR and virtual screening of 5α-reductase Ⅱ inhibitors of 6-azasteroids
四川大学学报. 自然科学版, 2018 Three-dimensional quantitative structure-activity relationship analysis of 37 6-azasteroids inhibitors was carried out by Topomer CoMFA. The new model’s cross validation and correlation coefficient were q2=0.774 and r2=0.965, respectively.
LIU Hua +4 more
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