Results 11 to 20 of about 822 (147)
Indian Journal of Entomology, 2022 Effect of two azasteroids, 25-azacholestane and 25-azacoprostane was studied on growth and development of an economically important phytophagous pest, Helicoverpa armigera (Hubner) causing extensive damage to crops like cotton, pigeon pea, chickpea and ...
Rita Rath +3 more
semanticscholar +1 more source
The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. [PDF]
Adv Urol, 2012 Despite the discovery of 5 alpha‐reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha‐reduced steroids in human diseases was not appreciated until the discovery of 5 alpha‐reductase type 2 deficiency in 1974. Affected males are born
Azzouni F, Godoy A, Li Y, Mohler J.
europepmc +2 more sources
Synthesis and biological testing for pesticidal activity of 8-azasteroids
Proceedings of Universities. Applied Chemistry and Biotechnology, 2022 The aim of the present study is the synthesis and testing for pesticidal activities of 2,3-dimethoxy16,16-dimethyl-D-homo-8-azagona-1,3,5(10),13-tetraene-12,17а-one and 2,3-dimethoxy-16,16-dimethyl-dhomo-8-azagona-1,3,5(10),13-tetraene-12-imino-17а-one ...
A. N. Pyrko
semanticscholar +1 more source
Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group [PDF]
Journal of the Serbian Chemical Society, 2004 In the present paper, the preparation of 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3β-yl acetate (1)1,2 was used as the starting material, which was transformed to the key ...
Pavlović Vladimir D. +4 more
doaj +1 more source
Clinical and Translational Medicine, Volume 10, Issue 8, December 2020., 2020 Schematic representation of cause, exacerbation and consequence of vaccines‐induced diverse immune disorders in immune‐responsive or immune‐privileged tissues. It depicts that vaccination of the unborn, alter biology of trophoblast‐embryo‐fetus‐placenta and orderly growth and development affecting epithelial‐mesenchymal transition, proper expression of
Mahin Khatami
wiley +1 more source
Journal of Spectroscopy, Volume 2013, Issue 1, 2013., 2013 The present paper reports the synthesis and spectroscopic characterization of few N‐2′‐hydroxyethyl‐substituted azacholestanes using BF3‐OEt2, TiCl4, SnCl4, and H2SO4 as catalysts in moderate yields by a modified version of Schmidt reaction. A notable feature is the passivity of SnCl4 in case of 3β‐acetoxy‐N‐2′‐hydroxyethyl‐6‐aza‐B‐homo‐5α‐cholestan‐7 ...
Shahab A. A. Nami +6 more
wiley +1 more source
Synthesis of 5-azaandrostane-3b,17b-diol protected at the 17b-hydroxyl group [PDF]
Journal of the Serbian Chemical Society, 2004 In the present paper, the preparation of 3b-hydroxy-17b-dimethyl-tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3b-yl acetate (1) was used as the starting material, which was transformed to the key ...
JAROSLAV KALVODA +4 more
doaj
3D-QSAR and virtual screening of 5α-reductase Ⅱ inhibitors of 6-azasteroids
四川大学学报. 自然科学版, 2018 Three-dimensional quantitative structure-activity relationship analysis of 37 6-azasteroids inhibitors was carried out by Topomer CoMFA. The new model’s cross validation and correlation coefficient were q2=0.774 and r2=0.965, respectively.
LIU Hua +4 more
doaj
EFFECT OF ORALLY ADMINISTERED AZASTEROIDS ON IMPLANTATION IN RATS [PDF]
Reproduction, 1969 Summary. Nine azasteroids have been evaluated for antifertility effect in rats when fed orally from Days 1 to 4 of pregnancy at the dose of 10 mg/kg body weight. The compounds 3β-hydroxy-androst-5-ene (16, 17-C)-5-methyl-pyrazole and 1,2,3,4-tetrahydro-N-tosyl-8-methoxy-4-oxo-benzo(b)quinoline inhibited pregnancy at that dose in a ...
S K, Saksena, R R, Chaudhury
openaire +2 more sources
Journal of Biological Chemistry, 2001 The inhibition of steroid 5α-reductase (5AR) by Δ1-4-azasteroids is characterized by a two-step time-dependent kinetic mechanism where inhibitor combines with enzyme in a fast equilibrium, defined by the inhibition constant K i , to form an initial ...
G. Tian, C. Haffner
semanticscholar +1 more source