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Treatment of hirsutism with 5 alpha-reductase inhibitors.
Clinics in endocrinology and metabolism, 1986Much os the evidence gathered from studies of 5 alpha-reductase activity levels and androgen metabolism in the skin of hirsute women and the excretion of androgen metabolites by hirsute women indicates that 5 alpha-reduced androgens are probably of primary importance in hirsutism.
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Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.
Pharmacotherapy, 1995Finasteride is a 4-azasteroid inhibitor of one isoenzyme of 5 alpha-reductases that converts testosterone to dihydrotestosterone (DHT). We characterized the time course of DHT concentrations. The following model was used to assess DHT pharmacodynamics: [formula: see text] where joint fitting of three dose levels yielded kin0 = 28% change/hour, kout = 0.
H C, Ko, W J, Jusko
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5-alpha reductase inhibitors and PSA screening for prostate cancer
Pathology, 2014Paul R, McKenzie +3 more
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[5-alpha reductase inhibitors and prostate cancer prevention].
Zhonghua nan ke xue = National journal of andrology, 20135-alpha reductase inhibitors decrease the level of dihydrotestosterone (DHT) by inhibiting 5-alpha reductase. Trials on 5-alpha reductase inhibitors in prostate cancer prevention showed that they could significantly decrease the incidence of prostate cancer, but meanwhile increase high-grade cases as well.
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