Results 131 to 140 of about 46,559 (243)

Design and synthesis of non-steroidal inhibitors of 5[alpha]-reductase

Androgen-dependent prostate cancer (PC) and benign prostate hyperplasia (BPH) can be treated either by surgical resection or through the use of drugs that produce androgen deprivation.
Denison, Sophie
core  

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Risk of Type 2 Diabetes Mellitus in New Users of 5-Alpha Reductase Inhibitors: A Nationwide Historical Cohort Study. [PDF]

Yonsei Med J
Nguyen MH, Ko J, Cho J.
europepmc   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis. [PDF]

Int Neurourol J
Niaga KJK, Rinaldi FX, Nathania N, Supinto PA, Lionardi SK, Yo R, Wilyono A, Silalahi PY.   +7 more
europepmc   +1 more source

Effects of 5-alpha reductase inhibitors on lung function: A reason for discontinuation during COVID-19 pandemic? [PDF]

Dermatol Ther, 2020
Kroumpouzos G.
europepmc   +1 more source

Integrating Prostate‐Specific Antigen Density and Prostate Imaging Reporting and Data System Scores to Optimize Detection of Clinically Significant Prostate Cancer: A Multivariable Risk Model Approach

Journal of Clinical Laboratory Analysis, EarlyView.
For the detection of clinically significant prostate cancer, incorporating PSA density into PI‐RADS‐based assessment improved clinical net benefit compared with PI‐RADS alone. The addition of DRE and age to this combined model produced only marginal further gain, indicating that most of the incremental clinical value was derived from PSA density rather
Yunus Kayali
wiley   +1 more source

Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in <i>Tectona grandis</i> L.f. (Teak) Leaves. [PDF]

Molecules
Tanuphol N, Girard C, Temkitthawon P, Suphrom N, Nuengchamnong N, Saesong T, Insumrong K, Wadeng A, Khangkhachit W, Zedet A, Intayot R, Jungsuttiwong S, Plubrukarn A, Senejoux F, Ingkaninan K.   +14 more
europepmc   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

An exploratory analysis of 5-alpha reductase inhibitors and risk of opioid use disorder among male Medicare beneficiaries receiving prescription opioid medications. [PDF]

Am J Addict
Tawfik AG, Lister T, Gomez-Lumbreras A, Peterson RT, Bortolato M, Malone DC.   +5 more
europepmc   +1 more source