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The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, EarlyView.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

The efficacy of tamsulosin 0.4 mg when tamsulosin 0.2 mg is insufficient for benign prostatic hyperplasia in Korean patients. [PDF]

Investig Clin Urol
Chung Y, Jeong SJ, Song SH, Hong SK.
europepmc   +1 more source

5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes. [PDF]

NeuroSci
Rodriguez-Cerdeira C.
europepmc   +1 more source

Medication Prescribing Observations in Care Transitions for Incarcerated Patients. [PDF]

Hosp Pharm
Shoulders BR, Maguigan KL, Lemon SJ.
europepmc   +1 more source

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5-Alpha-Reductase Inhibitors and Combination Therapy

Urologic Clinics of North America, 2016
By inhibiting the conversion from testosterone to dihydrotestosterone 5-Alpha reductase inhibitors (5ARIs) are able to hinder prostatic growth, shrink prostate volumes, and improve BPH-related LUTS. 5ARIs are particularly beneficial for patients with larger prostates (>30-40ml).
Claudius, Füllhase, Marc P, Schneider
openaire   +4 more sources

Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

ASSAY and Drug Development Technologies, 2019
Human steroid 5 alpha-reductases (S5αRs) and NADPH irreversibly reduce testosterone to the more potent dihydrotestosterone (DHT). S5αR inhibitors are useful treatments for DHT-dependent diseases, including benign prostatic hyperplasia, androgenic alopecia and hair growth, and acne.
Jukkarin, Srivilai, Genet, Minale, C Norman, Scholfield, Kornkanok, Ingkaninan   +3 more
openaire   +4 more sources

5 Alpha-reductase inhibitors: whatʼs new?

Current Opinion in Urology, 2003
Medical therapy is now the first-line treatment for most men with symptomatic benign prostatic hyperplasia. This review aims to highlight the recent contributions to our understanding of 5 alpha-reductase inhibitor usage.For the last decade, finasteride has been the only available 5 alpha-reductase inhibitor, acting upon the type 2 isoenzyme of 5-alpha
Charlotte L, Foley, Roger S, Kirby
openaire   +2 more sources

5-Alpha reductase inhibitors in active surveillance

Current Opinion in Urology, 2014
Active surveillance is now one of the recommended treatment options for low-risk prostate cancer (PCa). However, about 10-30% of men on active surveillance will progress and require definitive therapy. In this review, we examine the role of 5-alpha reductase inhibitors (5-ARIs) in secondary prevention among men with low-risk PCa who opted to be managed
Patrick O, Richard, Antonio, Finelli
openaire   +2 more sources