Results 81 to 90 of about 79,532,914 (276)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Do statins decrease testosterone in men? Systematic review and meta-analysis

International Brazilian Journal of Urology
Purpose: Statins are one of the most prescribed classes of drugs worldwide to treat hypercholesterolemia and dyslipidemia. By lowering the level of cholesterol, the use of statin could cause a reduction in testosterone levels.
Felipe Placco Araujo Glina, Leonardo Lopes, Rodrigo Spinola e Silva, Eduardo Augusto Correa Barros, Bruno Biselli, Sidney Glina   +5 more
doaj   +1 more source

Dynamics of prostate protectors assortment in the state formulary of medicines of 1-9 issues

Фармацевтичний журнал, 2018
Prostatitis is one of the most frequent urology diseases of men of reproductive age. Recommendations for rational pharmacotherapy prostatitis are included into the State Formulary of Medicines, which is reviewed and updated annually. Thus, the aim of our
І. V. Gadyak, B. P. Hromovyk
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

HPLC characterization, molecular docking, QSAR and molecular dynamics simulation of Alstonia boonei phytochemical analogs as potent 5-alpha reductase inhibitors

Discover Chemistry
Background Current chemotherapy for Benign Prostatic Hyperplasia (BPH) relies on 5-alpha reductase inhibitors like Finasteride and Dutasteride, which are associated with significant side effects.
Olumide Oluyele, Adedoyin John-Joy Owolade, Ayomide Precious Ajiboro, Victor Onoriode Unuaru, Temitope Ibukunoluwa Adegbenro, Adedapo Bolanle Esther, Bello Nafisat Oniboki, Oluwadetimi Oluwafunmilayo Ajayi, Chukwunenye Christopher Azubuike, Musiliyu Ayofe Salawu, Damilola Alex Omoboyowa, Damilola Samuel Bodun   +11 more
doaj   +1 more source

A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride

BMC Musculoskeletal Disorders, 2018
Background Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown.
Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani, David N. Juurlink, for the Canadian Drug Safety and Effectiveness Research Network   +8 more
doaj   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort ...
Spindler, Archie
core   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching:  Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase

, 2016
A hypothetical pharmacophore of 5α-reductase inhibitors was generated and served as a template in virtual screening. When the pharmacophore was used, eight isoflavone derivatives were characterized as novel potential nonsteroidal inhibitors of rat 5α ...
Chih-Shiang Chang (2361178), Grace Shiahuy Chen (2374888), Wai Ming Kan (3013248), Chih-Long Chang (436219), K. C. Wang (3013245), Ji-Wang Chern (1912126)   +5 more
core   +1 more source