Results 41 to 50 of about 84,609,228 (161)
Journal of Biological Chemistry, 2014 Background: Aminolevulinate synthase (ALAS) catalyzes decarboxylative condensation of glycine with succinyl-CoA yielding 5-aminolevulinate. Results: Unstable ALAS-catalyzed reaction intermediates and conformational changes were characterized using ...
B. Stojanovski +4 more
semanticscholar +1 more source
Effect of dexamethasone on mRNA levels for 5-aminolevulinate synthase in different rat tissues
, 1992 5-Aminolevulinate synthase mRNA levels from different tissues were quantitated by Northern blot hybridization analysis utilizing the rat liver 5-aminolevulinate synthase cDNA clone as probe.
May, BK +3 more
core +1 more source
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase [PDF]
, 1990 1. 1. Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of δ-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing ...
Polo, C.F. +3 more
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Biochimica et Biophysica Acta, 2014 5-Aminolevulinate synthase (ALAS), a pyridoxal-5′phosphate (PLP)-dependent enzyme, catalyzes the first step of heme biosynthesis in mammals. Circular dichroism (CD) and fluorescence spectroscopies were used to examine the effects of pH (1.0–3.0 and 7.5 ...
B. Stojanovski +4 more
semanticscholar +1 more source
Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects
BMEMat, Volume 3, Issue 2, June 2025.This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen +6 more
wiley +1 more source
Journal of Biomedical Optics, 2014 . Hexyl 5-aminolevulinate (HAL) is a lipophilic derivative of 5-aminolevulinate, a key intermediate in biosynthesis of the photosensitizer protoporphyrin IX (PpIX). The photodynamic efficacy and cell death mode after red versus blue light illumination of
L. Helander +4 more
semanticscholar +1 more source
IUBMB Life, Volume 76, Issue 12, Page 1011-1034, December 2024.Abstract Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably, such non‐ apoptotic and iron‐dependent regulated cell death has been found to be intricately linked to ...
Aliki Papadimitriou‐Tsantarliotou +3 more
wiley +1 more source
Molecular Medicine, 2013 X-linked protoporphyria (XLP) (MIM 300752) is a recently recognized erythropoietic porphyria due to gain-of-function mutations in the erythroid-specific aminolevulinate synthase gene (ALAS2).
D. Bishop +3 more
semanticscholar +1 more source
The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species. [PDF]
, 2016 Methyl-aminolevulinate-based photodynamic therapy (MAL-PDT) is utilised clinically for the treatment of non-melanoma skin cancers and pre-cancers and the hydroxypyridinone iron chelator, CP94, has successfully been demonstrated to increase MAL-PDT ...
Y Dogra (21850751) +5 more
core +4 more sources
METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS [PDF]
, 2003 The present inventors have discovered that Asparagine Synthase, 5- Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase are essential for fungal pathogenicity.
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