Results 21 to 30 of about 84,609,228 (161)
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Exploring the mechanisms of glycolytic genes involvement in pulmonary arterial hypertension through integrative bioinformatics analysis. [PDF]
J Cell Mol MedAbstract The purpose of this study was to identify the mechanisms underlying the involvement of glycolytic genes in pulmonary arterial hypertension (PAH). This study involved downloading 3 datasets from the GEO database at the National Center for Biotechnology Information. The datasets were processed to obtain expression matrices for analysis.
Lou YX, Shi ED, Yang R, Yang Y.
europepmc +2 more sources
Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis
Advanced Science, Volume 10, Issue 6, February 24, 2023., 2023 Here, the development of an engineered E. coli strain capable of improved heme supply suitable for whole‐cell P450 biocatalysts is reported. The intracellular heme level is fine‐tuned by the combined use of mutated heme‐sensitive biosensors and small regulatory RNA systems.
Baodong Hu +7 more
wiley +1 more source
Blood, 2018 During erythroid differentiation, the erythron must remodel its protein constituents so that the mature red cell contains hemoglobin as the chief cytoplasmic protein component.
Joseph S. Burch +7 more
semanticscholar +1 more source
Porphyrin biosynthesis in Rhodopseudomonas palustris-XII. δ-aminolevulinate synthetase switch-off/on regulation [PDF]
, 1987 The high levels of δ-aminolevulinate synthetase (ALA-S) in Rhodopseudomonas palustris cells grown anaerobically in the light (Ph) decrease to those found in cells grown aerobically in the dark (A), when the former cultures were vigorously oxygenated ...
Del C. Batlle, A.M. +2 more
core +2 more sources
Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy
Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva +5 more
wiley +1 more source
5-Aminolevulinate Synthase Catalysis: The Catcher in Heme Biosynthesis
Molecular Genetics and Metabolism, 2019 5-Aminolevulinate (ALA) synthase (ALAS), a homodimeric pyridoxal-5’-phosphate (PLP)-dependent enzyme, catalyzes the first step of heme biosynthesis in metazoa, fungi and α-proteobacteria.
B. Stojanovski +5 more
semanticscholar +1 more source
5-aminolevulinate synthase inhibitors and methods of use thereof
, 2022 Disclosed herein, are 5-Aminolevulinate synthase inhibitors and methods for their use in the treatment of porphyria. In at least one specific embodiment, the 5-Aminolevulinate synthase inhibitors can include compounds or salts thereof of Formulas (I ...
Ferreira, Gloria C. +3 more
core
Regulation of 5-aminolevulinate synthase mRNA in different rat tissues
, 1988 Regulation of 5-aminolevulinate synthase mRNA in different rat ...
IA Borthwick (14582741) +6 more
core +2 more sources
Molecular cloning of hepatic 5-aminolevulinate synthase.
, 1984 Hepatic 5-aminolevulinate synthase was induced in chick embryos by administration of the porphyrinogenic drugs 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
May, BK +6 more
core +1 more source