Results 11 to 20 of about 84,609,228 (161)

Heme synthesis in Crithidia deanei: influence of the endosymbiote. [PDF]

International Journal of Biochemistry, 1985
1. 1. The activity of the following enzymes involved in the biosynthesis of porphyrins was determined in endosymbiote-free and endosymbiote-containing Crithidia deanei grown in a chemically defined medium: succinyl Coenzyme A synthetase (Suc.CoA-S), 5 ...
T. Salzman, A. Batlle, J. Angluster, W. de Souza   +3 more
semanticscholar   +4 more sources

Chlorophyll biosynthesis in higher plants. Regulatory aspects of 5-aminolevulinate formation

Journal of Plant Biology, 2003
Chlorophyll, heme, phytochrome and siroheme biosynthesis in higher plants is regulated by the supply of their precursor 5-aminolevulinate (ALA), which is derived from glutamate.
S. Gough, T. Westergren, M. Hansson
semanticscholar   +2 more sources

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Smuder AJ, Doerr V, Jacintho Moritz CE, Li J, Nguyen BL.   +4 more
europepmc   +2 more sources

SUPPRESSION OF THE INDUCTION OF HEPATIC DELTA-AMINOLEVULINATE SYNTHETASE BY GLUCOSE.

, 1974
SUPPRESSION OF THE INDUCTION OF HEPATIC DELTA-AMINOLEVULINATE SYNTHETASE BY ...
TUAN-GEE. YAP (7972157)
core   +6 more sources

Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study.

Journal of American Academy of Dermatology, 2002
Background: Actinic keratoses (AKs) are the most common premalignant tumors. Without treatment, a significant number of patients with AK will experience squamous cell carcinoma.
R. Szeimies, S. Karrer, S. Radakovic-Fijan, A. Tanew, P. Calzavara-Pinton, C. Zane, A. Sidoroff, M. Hempel, J. Ulrich, T. Proebstle, H. Meffert, M. Mulder, D. Salomon, H. Dittmar, J. Bauer, K. Kernland, L. Braathen   +16 more
semanticscholar   +2 more sources

Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities. [PDF]

J Inherit Metab Dis
The graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Isermann L, Trifunovic A.
europepmc   +2 more sources

Unveiling the Potential of Lentilactobacillus hilgardii in Malolactic Fermentation: Comparative Genomics and Fermentation Dynamics. [PDF]

Microb Biotechnol
This study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Mantegazza G, Mangieri N, Yazdi EV, Russo P, Mora D, Gargari G.   +5 more
europepmc   +2 more sources

5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury

Theranostics, 2023
Rationale: Liver resection and transplantation surgeries are accompanied by hepatic ischemia-reperfusion (HIR) injury that hampers the subsequent liver recovery.
Guanghui Jin, Na Guo, Ya-Song Liu, Lele Zhang, Liang Chen, Tao Dong, Wei Liu, Xiaomei Zhang, Yongfang Jiang, Guoshi Lv, Fei Zhao, Z. Hei, Yang Yang, Jingxing Ou   +13 more
semanticscholar   +1 more source

Photodynamic therapy of cancer-associated infections. [PDF]

Photochem Photobiol
Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Kassab G, Chen J, Zheng G.
europepmc   +2 more sources

5-Aminolevulinate improves metabolic recovery and cell survival of the liver following cold preservation

Theranostics, 2022
Rationale: Hibernating thirteen-lined ground squirrels (GS; Ictidomys tridecemlineatus) are naturally adapted to prolonged periods of ultraprofound hypothermia (body temperature < 5 ºC) during torpor, and drastic oscillations of body temperature and ...
Xiaomei Zhang, Liang Chen, Wei Liu, Juan Shen, Haobin Sun, Jinliang Liang, Guoshi Lv, Gui-Hua Chen, Yang Yang, Jingxing Ou   +9 more
semanticscholar   +1 more source