Results 11 to 20 of about 1,146 (98)
Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Smuder AJ +4 more
europepmc +2 more sources
Unveiling the Potential of Lentilactobacillus hilgardii in Malolactic Fermentation: Comparative Genomics and Fermentation Dynamics. [PDF]
Microb BiotechnolThis study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Mantegazza G +5 more
europepmc +2 more sources
Photodynamic therapy of cancer-associated infections. [PDF]
Photochem PhotobiolPathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Kassab G, Chen J, Zheng G.
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis
Advanced Science, Volume 10, Issue 6, February 24, 2023., 2023 Here, the development of an engineered E. coli strain capable of improved heme supply suitable for whole‐cell P450 biocatalysts is reported. The intracellular heme level is fine‐tuned by the combined use of mutated heme‐sensitive biosensors and small regulatory RNA systems.
Baodong Hu +7 more
wiley +1 more source
Ecology and Evolution, Volume 12, Issue 10, October 2022., 2022 Mild intermittend hypoxia extends lifespan in Daphnia clones from intermittent ponds, but not from permanent ponds and does not provide added protection against acute severe hypoxia. Several pathways, including glycolysis and gluconeogenesis as well as cuticular proteins and neurotrophins are upregulated by acute hypoxia, in the manner consistent with ...
Millicent N. Ekwudo +3 more
wiley +1 more source
The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway
FEBS Letters, Volume 596, Issue 18, Page 2345-2363, September 2022., 2022 This study introduces the concept of the ‘anteome’, from the Latin ante, to define the upstream metabolic pathways that need to converge upon other pathways, in this case, the sphingolipid metabolic pathway, to allow the pathway to function. We suggest that current evolutionary models cannot explain the appearance of the sphingolipid metabolic pathway ...
Tania C. B. Santos +2 more
wiley +1 more source
Exploring the mechanisms of glycolytic genes involvement in pulmonary arterial hypertension through integrative bioinformatics analysis [PDF]
J Cell Mol MedAbstract The purpose of this study was to identify the mechanisms underlying the involvement of glycolytic genes in pulmonary arterial hypertension (PAH). This study involved downloading 3 datasets from the GEO database at the National Center for Biotechnology Information. The datasets were processed to obtain expression matrices for analysis.
Lou Y, Shi E, Yang R, Yang Y.
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT Cobalamin (vitamin B12) is an essential cofactor for two human enzymes, methionine synthase and methylmalonyl‐CoA mutase. Inborn errors of cobalamin metabolism (IECMs) are inherited genetic defects resulting in improper transport, modification, or utilization of cobalamin and include inherited methylmalonic acidurias, a group of IECMs most ...
Almut Heinken +5 more
wiley +1 more source