Results 191 to 200 of about 30,571 (234)

5-Aminolevulinic Acid Induces Iron Release from Ferritin

Archives of Biochemistry and Biophysics, 1995
5-Aminolevulinic acid (ALA), a heme precursor accumulated in acute intermittent porphyria (AIP) and lead poisoning, undergoes metal-catalyzed oxidation in air-equilibrated solutions buffered at neutral pH, yielding free radicals (O2, HO. and ALA.).
P I, Oteiza, C G, Kleinman, M, Demasi, E J, Bechara   +3 more
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The stability of 5-aminolevulinic acid in solution

Journal of Photochemistry and Photobiology B: Biology, 2002
5-Aminolevulinic acid (ALA) is being assessed for photodynamic therapy of cancer and other diseases worldwide. However, its stability properties in solution are not well understood yet. The breakdown of ALA in pH-buffered solutions was examined in this work.
Øystein Bech, Gadmar, Johan, Moan, Eldri, Scheie, Li-Wei, Ma, Qian, Peng   +4 more
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Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas

Acta Neurochirurgica, 2010
5-aminolevulinic acid (5-ALA) has gained importance as an intraoperative photodynamic diagnostic agent for the extirpation of malignant gliomas. The application of this technique for resection of meningiomas has barely been explored. The aim of this study was to evaluate the utility of 5-ALA-induced fluorescence as a visual tool in meningioma resection
Daniel, Coluccia, Javier, Fandino, Masayuki, Fujioka, Susanne, Cordovi, Carl, Muroi, Hans, Landolt   +5 more
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Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid

Surgical Endoscopy, 2000
The diagnosis of nonpigmented endometrial lesions by simple laparoscopic visualization is difficult and often inaccurate. We therefore sought to establish a new and more accurate method to visualize these nonpigmented peritoneal changes caused by endometriosis.A total of 37 patients received 30 mg 5-aminolevulinic acid/kg body weight 10 to 14 hs prior ...
E, Malik, C, Berg, A, Meyhöfer-Malik, O, Buchweitz, P, Moubayed, K, Diedrich   +5 more
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Degradation mechanism and stability of 5‐aminolevulinic acid

Journal of Pharmaceutical Sciences, 2000
The physiological substance and precursor of the heme synthesis 5-aminolevulinic acid (ALA) is a promising prodrug for photodiagnosis and photodynamic therapy of epithelial tumors, particularly in urological and gynecological tissues. For the clinical use of this substance, a chemically stable and sterile drug formulation is required.
A, Bunke, O, Zerbe, H, Schmid, G, Burmeister, H P, Merkle, B, Gander   +5 more
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5-Aminolevulinic Acid: Acne Vulgaris

2011
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is a widely used, although off-label, treatment for moderate to severe acne in the USA. Still in its infancy, this treatment has confounded our better wisdom for best practices as studies have been limited and largely carried out in small, investigator-initiated clinical trials.
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5-Aminolevulinic Acid, but not 5-Aminolevulinic Acid Esters, is Transported into Adenocarcinoma Cells by System BETA Transporters

Photochemistry and Photobiology, 2000
5-aminolevulinic acid (5-ALA) and its ester derivatives are used in photodynamic therapy as precursors for the formation of photosensitizers. This study relates to the mechanisms by which 5-ALA is transported into cells. The transport of 5-ALA has been studied in a human adenocarcinoma cell line (WiDr) by means of [14C]-labeled 5-ALA.
E, Rud, O, Gederaas, A, Høgset, K, Berg
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Urinary 5-aminolevulinic acid in lead-exposed children

Biomarkers, 1999
Lead intoxication can interfere with haem synthesis and alter the concentration of haem precursors, such as the neurotoxin 5-aminolevulinic acid, in plasma and urine. The relationship between blood lead concentration (PbB), a biomarker of lead exposure, and 5-aminolevulinic acid concentration in urine (ALAU), a biomarker of the early biological effect ...
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Production of 5-aminolevulinic acid by methanogens

Journal of Fermentation and Bioengineering, 1989
Abstract The possibility of 5-aminolevulinic acid (ALA) accumulation in a culture medium was studied using Methanosarcina barkeri growing on a methanol minimal medium. To effect the accumulation of ALA in the culture medium, some ALA analogues were tested as inhibitors of ALA dehydratase.
Dong Lin, Naomichi Nishio, Shiro Nagai
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[Fluorescence cystoscopy using 5-aminolevulinic acid].

Casopis lekaru ceskych, 2003
Fluorescence diagnosis has an increasing importance in different medical fields. In the presented paper, comparison of cystoscopy in white light with fluorescence cystoscopy after intravesical administration of 1 g of 5-aminolevulinic acid is presented.From the group of 63 persons examined, no difference between findings in white and blue light was ...
M, Jirsa, M, Babjuk, R, Petrík, J, Dvorácek, M, Urban, O, Köhler   +5 more
openaire   +1 more source