Results 1 to 10 of about 6,641 (157)
Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester
Medicina (Lithuania), 2009 Objective. The incidence of malignant skin tumors is rapidly increasing. Early diagnosis, determining the margins of the tumor, is extremely important to achieve good treatment results. We investigated fluorescence of protoporphyrin IX in skin carcinomas.
Saulė Šimkutė +3 more
exaly +4 more sources
Tetrahedron Letters, 2015 The development of a novel tumor-targeting photosensitizer delivery system, with potential ability to selectively transport the photosensitizer prodrug 5-aminolevulinic acid methyl ester (MAL) into the tumor site has been herein described.
Annalisa Guaragna +2 more
exaly +4 more sources
Influence of Light Exposure on the Kinetics of Protoporphyrin IX Formation in Normal Skin of Hairless Mice After Application of 5-Aminolevulinic Acid Methyl Ester [PDF]
Journal of Investigative Dermatology, 2005 The rates of protoporphyrin IX (PpIX) photodegradation and reappearance after light exposure at 420 and 632 nm were measured in mouse skin at different times after 1 h topical application of 5-aminolevulinic acid methyl ester (ALA-Me).
Johan Moan, Liwei Ma, Vladimir Iani
exaly +4 more sources
Journal of Controlled Release, 2004 The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein, propylene glycol and aqueous buffer at concentrations of approximately 0.25% and 16% w/w m-ALA.
Emma Sparr +2 more
exaly +5 more sources
Photodynamic inactivation of Klebsiella pneumoniae biofilms and planktonic cells by 5-aminolevulinic acid and 5-aminolevulinic acid methyl ester [PDF]
Lasers in Medical Science, 2016 The treatment of Klebsiella pneumoniae, particularly extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae, is currently a great challenge. Photodynamic antimicrobial chemotherapy is a promising approach for killing antibiotic-resistant bacteria ...
Ishaq, HM +7 more
core +5 more sources
Practical Considerations in the Pharmaceutical Analysis of Methyl and Hexyl Ester Derivatives of 5-Aminolevulinic Acid [PDF]
The Open Analytical Chemistry Journal, 2009 Photodynamic therapy (PDT) using topical 5-aminolevulinic acid (ALA), a water-soluble precursor of the potent endogenous photosensitiser, protoporphyrin IX (PpIX), is a treatment and diagnostic tool for premalignant and malignant skin cancers. However, to improve drug delivery to deeper skin lesions, more lipophilic ALA esters have been investigated ...
Desmond I J Morrow +2 more
exaly +2 more sources
Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy. [PDF]
PLoS ONE, 2013 Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are used as pro-drugs to induce the formation of the potent photosensitizer ...
Yan Baglo +3 more
doaj +3 more sources
Biomedical Photonics, 2023 Acne is one of the most common skin conditions in the world. A number of studies have shown that photodynamic therapy (PDT) is safe and effective for both inflammatory and non-inflammatory acne and can significantly improve skin conditions in this ...
E. V. Filonenko, V. I. Ivanova-Radkevich
doaj +1 more source
Photodynamic therapy of psoriasis
Biomedical Photonics, 2023 Photodynamic therapy (PDT) in the treatment of psoriasis remains the subject of much debate. There is no consensus in the scientific community about effective and safe PDT regimens for psoriasis.
E. V. Filonenko, V. Ivanova-Radkevich
doaj +1 more source
Photodynamic therapy in the treatment of extramammary paget’s disease
Biomedical Photonics, 2022 Extramammary Paget’s disease (EMPD) is a rare tumor that predominantly affects the skin containing apocrine glands. Due to insufficient data on the effectiveness of different methods, there is no single therapeutic approach to the treatment of patients ...
E. V. Filonenko, V. Ivanova-Radkevich
doaj +1 more source