Results 221 to 230 of about 34,838 (281)

Fluorescence-Guided Surgery Using 5-Aminolevulinic Acid/Protoporphyrin IX in Brain Metastases. [PDF]

open access: yesNeurosurg Pract
Price A   +9 more
europepmc   +1 more source

5-Aminolevulinic acid synthase: mechanism, mutations and medicine

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2003
5-Aminolevulinic acid synthase (ALAS), the first enzyme of the heme biosynthesis pathway, catalyses the pyridoxal 5'-phosphate-dependent condensation between glycine and succinyl-CoA to yield 5-aminolevulinic acid (5-amino-4-oxopentanoate). A three-dimensional structural model of Rhodobacter spheroides ALAS has been constructed and used to identify ...
Peter M Shoolingin-Jordan   +2 more
exaly   +3 more sources

5-Aminolevulinic Acid Imaging of Malignant Glioma

Surgical Oncology Clinics of North America, 2022
High-grade glioma is the most common malignant primary brain tumor in adults. Glioma infiltration renders it difficult to treat and likely to recur. Increasing the extent of resection has been associated with improving progression-free survival and overall survival by several months. The introduction of 5-aminolevulinic acid (5-ALA) fluorescence-guided
Guan, Li   +6 more
openaire   +2 more sources

The stability of 5-aminolevulinic acid in solution

Journal of Photochemistry and Photobiology B: Biology, 2002
5-Aminolevulinic acid (ALA) is being assessed for photodynamic therapy of cancer and other diseases worldwide. However, its stability properties in solution are not well understood yet. The breakdown of ALA in pH-buffered solutions was examined in this work.
Øystein Bech, Gadmar   +4 more
openaire   +2 more sources

5-Aminolevulinic Acid, but not 5-Aminolevulinic Acid Esters, is Transported into Adenocarcinoma Cells by System BETA Transporters

Photochemistry and Photobiology, 2000
5-aminolevulinic acid (5-ALA) and its ester derivatives are used in photodynamic therapy as precursors for the formation of photosensitizers. This study relates to the mechanisms by which 5-ALA is transported into cells. The transport of 5-ALA has been studied in a human adenocarcinoma cell line (WiDr) by means of [14C]-labeled 5-ALA.
E, Rud, O, Gederaas, A, Høgset, K, Berg
openaire   +2 more sources

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