Results 231 to 240 of about 34,838 (281)

5-Aminolevulinic Acid-Hyaluronic Acid Complexes Enhance Skin Retention of 5-Aminolevulinic Acid and Therapeutic Efficacy in the Treatment of Hypertrophic Scar

AAPS PharmSciTech, 2022
Hypertrophic scar is a serious skin disorder, which reduces the patient's quality of life. 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy has been used to treat patients with hypertrophic scar. However, the poor skin retention of 5-ALA limited the therapeutic effect.
Liya, Yang, Huihui, Deng, Yiman, Chen, Yuling, Chen, Ling, Guo, Min, Feng   +5 more
openaire   +2 more sources

Hemodynamic effects of 5-aminolevulinic acid in humans

Journal of Photochemistry and Photobiology B: Biology, 1998
Endogenous protoporphyrin IX (PpIX), which results from the oral administration of 5-aminolevulinic acid (ALA), is being investigated for its efficacy as a photosensitizing agent for photodynamic therapy (PDT). Clinical use of ALA has been associated with only mild gastrointestinal side effects.
M A, Herman, J, Webber, D, Fromm, D, Kessel   +3 more
openaire   +2 more sources

Oxidative damage to ferritin by 5-aminolevulinic acid

Archives of Biochemistry and Biophysics, 2003
5-Aminolevulinic acid (ALA), a heme precursor overproduced in various porphyric disorders, has been implicated in iron-mediated oxidative damage to biomolecules and cell structures. From previous observations of ferritin iron release by ALA, we investigated the ability of ALA to cause oxidative damage to ferritin apoprotein.
Maria E.M Rocha, Fernando Dutra, Brian Bandy, Regina L Baldini, Suely L Gomes, Adelaide Faljoni-Alário, Cleber W Liria, M Terêsa, M Miranda, Etelvino J.H Bechara   +9 more
openaire   +2 more sources

Fluorometric measurement of 5-aminolevulinic acid in serum

Clinica Chimica Acta, 2004
Measurement of 5-aminolevulinic acid (ALA) in serum is potentially useful in acute porphyrias, lead poisoning and hereditary tyrosinemia. Because levels of ALA in serum are about 100 times less than in urine, a highly sensitive method is required. We describe a simple and sensitive fluorometric method that does not require HPLC.ALA is separated from ...
Chul, Lee, Xian, Qiao, Douglas E, Goeger, Karl E, Anderson   +3 more
openaire   +2 more sources

Microbial production and applications of 5-aminolevulinic acid

Applied Microbiology and Biotechnology, 2014
5-Aminolevulinic acid (ALA), an important intermediate in tetrapyrrole biosynthesis in organisms, has been widely applied in many fields, such as medicine, agriculture, and the food industry, due to its biochemical characteristics. Research efforts supporting the microbial production of ALA have received increasing interest due to its dominant ...
Shuli, Liu, Guangming, Zhang, Xiangkun, Li, Jie, Zhang   +3 more
openaire   +2 more sources

5-Aminolevulinic Acid–Shedding Light on Where to Focus

World Neurosurgery, 2021
Surgical management of gliomas is predicated on "safe maximal resection" across all histopathologic grades because progression-free survival and overall survival are positively affected by the increasing extent of resection. Administration of the prodrug 5-aminolevulinic acid (5-ALA) induces tumor fluorescence with high specificity and sensitivity for ...
Nicholas B. Dadario, Deepak Khatri, Noah Reichman, Chibueze D. Nwagwu, Randy S. D'Amico   +4 more
openaire   +2 more sources

Effects of 5-aminolevulinic acid on the glutamatergic neurotransmission

Neurochemistry International, 2003
The haem precursor 5-aminolevulinic acid (ALA) has been proposed to be involved in the neurological dysfunctions presented by patients with acute porphyrias. The effects of ALA on the [3H]glutamate and [3H]MK-801 (dizocilpine) binding to rat cortical membranes and on [3H]glutamate uptake by rat astrocyte cultures were evaluated in the present study in ...
Tatiana, Emanuelli, Fernanda W, Pagel, Lisiane O, Porciúncula, Diogo O, Souza   +3 more
openaire   +2 more sources

Photosensitization of the endometrium with topical 5-aminolevulinic acid

American Journal of Obstetrics and Gynecology, 1995
Photosensitization of the endometrium was attempted in vitro and in vivo by intrauterine administration of 5-aminolevulinic acid, which is converted to the photosensitizer protoporphyrin IX. Protoporphyrin IX was found in both functional and basal layers of the endometrial glands at concentrations nine and 10 times higher than myometrium in in vitro ...
M J, Gannon, N, Johnson, D J, Roberts, J A, Holroyd, D I, Vernon, S B, Brown, R J, Lilford   +6 more
openaire   +2 more sources

Biosynthesis of 5-Aminolevulinic Acid

2009
5-Aminolevulinic acid (ALA) is the general precursor of all known tetrapyrroles. Currently, two different biosynthetic routes for ALA formation are known. Humans, animals, fungi and the α-group of the proteobacteria employ the one-step-condensation of succinyl-coenzyme A and glycine catalyzed by pyridoxal 5′-phosphate-dependent ALA synthase. In plants,
Dieter Jahn, Dirk W. Heinz
openaire   +1 more source

Degradation mechanism and stability of 5‐aminolevulinic acid

Journal of Pharmaceutical Sciences, 2000
The physiological substance and precursor of the heme synthesis 5-aminolevulinic acid (ALA) is a promising prodrug for photodiagnosis and photodynamic therapy of epithelial tumors, particularly in urological and gynecological tissues. For the clinical use of this substance, a chemically stable and sterile drug formulation is required.
Bunke A, Zerbe O, Schmid H, Burmeister G, Merkle HP, Gander B   +5 more
openaire   +3 more sources