Results 241 to 250 of about 34,838 (281)

Production of 5-aminolevulinic acid by methanogens

Journal of Fermentation and Bioengineering, 1989
Abstract The possibility of 5-aminolevulinic acid (ALA) accumulation in a culture medium was studied using Methanosarcina barkeri growing on a methanol minimal medium. To effect the accumulation of ALA in the culture medium, some ALA analogues were tested as inhibitors of ALA dehydratase.
Dong Lin, Naomichi Nishio, Shiro Nagai
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Uroporphyria produced in mice by iron and 5-aminolevulinic acid

Biochemical Pharmacology, 1991
Porphyria cutanea tarda and the analogous hepatic uroporphyria produced in rodents by aromatic hydrocarbons result from inactivation of hepatic uroporphyrinogen decarboxylase (UROD). Inactivation appears to be iron-dependent and may require induction of cytochromes of the P450IA subfamily.
S, Deam, G H, Elder
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The Utility of 5-Aminolevulinic Acid for Microsurgical Resection of Meningiomas

World Neurosurgery, 2020
Fluorescence-guided resection of brain tumors using 5-aminolevulinic acid (5-ALA) has been established for high-grade gliomas. Recently, its application for the resection of low grade tumors and benign lesions including meningioma has been suggested in the literature.1 Achieving a Simpson grade I resection in meningioma surgery is associated with a ...
Evelyn L. Turcotte, Rudy J. Rahme, Sarah A. Merrill, Ryan A. Hess, Salvatore C. Lettieri, Bernard R. Bendok   +5 more
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Two biosynthetic pathways to 5-aminolevulinic acid in algae

International Journal of Biochemistry, 1980
Abstract 1. 1. In the X-ray induced mutant C-2A' of the green alga Scenedesmus obliquus, the formation of 5-aminolevulinic acid (LALA) is light dependent. ALA so formed arises by the classical ALA synthetase pathway involving glycine and succinate as substrates and also by the C-5 pathway using the intact 5-carbon skeleton of glutamate or 2-keto ...
O, Klein, D, Dörnemann, H, Senger
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Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas

Acta Neurochirurgica, 2010
5-aminolevulinic acid (5-ALA) has gained importance as an intraoperative photodynamic diagnostic agent for the extirpation of malignant gliomas. The application of this technique for resection of meningiomas has barely been explored. The aim of this study was to evaluate the utility of 5-ALA-induced fluorescence as a visual tool in meningioma resection
Coluccia D, Fandino J, Fujioka M, Cordovi S, Muroi C, Landolt H   +5 more
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Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid

Surgical Endoscopy, 2000
The diagnosis of nonpigmented endometrial lesions by simple laparoscopic visualization is difficult and often inaccurate. We therefore sought to establish a new and more accurate method to visualize these nonpigmented peritoneal changes caused by endometriosis.A total of 37 patients received 30 mg 5-aminolevulinic acid/kg body weight 10 to 14 hs prior ...
E, Malik, C, Berg, A, Meyhöfer-Malik, O, Buchweitz, P, Moubayed, K, Diedrich   +5 more
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Pharmaceutical analysis of 5-aminolevulinic acid in solution and in tissues

Journal of Photochemistry and Photobiology B: Biology, 2006
Quantification of 5-aminolevulinic acid (ALA) in solution, and methods used to achieve this, have been extensively reported in the literature. However, validated methods have only rarely been presented and never have methods been compared. Due to a necessity in drug delivery research for optimised and validated methods for determination of ALA in ...
Donnelly, Ryan, Morrow, D.I.J., McCarron, Paul, Juzenas, P., Woolfson, David   +4 more
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5-Aminolevulinic acid synthesis in epimastigotes of Trypanosoma cruzi

The International Journal of Biochemistry & Cell Biology, 2003
Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis. The parasite manifests a nutritional requirement for heme compounds because of its biosynthesis deficiency. The aim of this study has been to investigate the presence of metabolites and enzymes of porphyrin pathway, as well as ALA formation in epimastigotes of T ...
María Elisa, Lombardo, Lidia Susana, Araujo, Alcira, Batlle   +2 more
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Treatment of viral infections with 5-aminolevulinic acid and light

Lasers in Surgery and Medicine, 1997
When 5-aminolevulinic acid (ALA) is exogenously supplied, protoporphyrin IX (PpIX) is accumulated in various cells and makes them light sensitive. The possibility of using such an approach for the treatment of viral infections was studied in this work.ALA was added to cultured cells infected with human immunodeficiency virus (HIV). Accumulation of PpIX
Z, Smetana, Z, Malik, A, Orenstein, E, Mendelson, E, Ben-Hur   +4 more
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Pleiotropic effects of 5-aminolevulinic acid in mouse brain

Biochemistry and Cell Biology, 2016
5-Aminolevulinic acid (ALA) seems to be responsible for the neuropsychiatric manifestations of acute intermittent porphyria (AIP). Our aim was to study the effect of ALA on the different metabolic pathways in the mouse brain to enhance our knowledge about the action of this heme precursor on the central nervous system. Heme metabolism, the cholinergic
Jimena, Lavandera, Jorge, Rodríguez, Silvina, Ruspini, Roberto, Meiss, Johanna Romina, Zuccoli, María Del Carmen, Martínez, Esther, Gerez, Alcira, Batlle, Ana María, Buzaleh   +8 more
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