Results 121 to 130 of about 14,105,510 (156)

On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms. [PDF]

Int J Mol Sci
Zdubek A, Maliszewska I.
europepmc   +1 more source

Efficacy of Aminolevulinic Acid Mediated Photodynamic Therapy in the Treatment of Oral Premalignant Lesions: A Systematic Review. [PDF]

Asian Pac J Cancer Prev
Bordoloi B, Goswami A, Roy D, Goswami P, Das I.   +4 more
europepmc   +1 more source

Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester

Medicina (Lithuania), 2009
Objective. The incidence of malignant skin tumors is rapidly increasing. Early diagnosis, determining the margins of the tumor, is extremely important to achieve good treatment results. We investigated fluorescence of protoporphyrin IX in skin carcinomas.
Navickienė, Jurgita, Mordas, Aleksandras, Šimkutė, Saulė, Bloznelytė-Plnienė, Laima   +3 more
exaly   +4 more sources

Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy

Tetrahedron Letters, 2015
The development of a novel tumor-targeting photosensitizer delivery system, with potential ability to selectively transport the photosensitizer prodrug 5-aminolevulinic acid methyl ester (MAL) into the tumor site has been herein described. Conjugation of MAL to folic acid (FA) via an unnatural ?-peptide linker has been carried out almost entirely by an
Giovanni Roviello, Annalisa Guaragna, Giovanni Palumbo   +2 more
exaly   +4 more sources

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Iontophoretic delivery of 5-aminolevulinic acid and its methyl ester using a carbopol gel as vehicle

Journal of Controlled Release, 2004
The aim of this study was to evaluate a Carbopol gel as a vehicle for iontophoretic delivery of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA). The formulation was characterized rheologically and the passive diffusion of ALA and m-ALA in the gels was measured.
Tobias Bramer, Katarina Edsman
exaly   +3 more sources

Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers

Journal of Cancer Research and Clinical Oncology, 2010
Photodynamic therapy (PDT) is a new approach to cancer treatment that utilizes photochemical reactions induced by a combination of an oncophilic photosensitizing agent and laser light. With an aim to apply PDT for intraperitoneal disseminated foci of advanced or recurrent ovarian cancers, the present study was conducted to evaluate the antitumor effect
Makoto Wakui, H Mizunuma
exaly   +3 more sources

Influence of Light Exposure on the Kinetics of Protoporphyrin IX Formation in Normal Skin of Hairless Mice After Application of 5-Aminolevulinic Acid Methyl Ester [PDF]

Journal of Investigative Dermatology, 2005
The rates of protoporphyrin IX (PpIX) photodegradation and reappearance after light exposure at 420 and 632 nm were measured in mouse skin at different times after 1 h topical application of 5-aminolevulinic acid methyl ester (ALA-Me). After ALA-Me application (1 h) and removal, the fluorescence of PpIX increased for about 1 h, and then reached a ...
Asta Juzeniene, Vladimir Iani
exaly   +3 more sources

Practical Considerations in the Pharmaceutical Analysis of Methyl and Hexyl Ester Derivatives of 5-Aminolevulinic Acid [PDF]

AACE Clinical Case Reports, 2009
Photodynamic therapy (PDT) using topical 5-aminolevulinic acid (ALA), a water-soluble precursor of the potent endogenous photosensitiser, protoporphyrin IX (PpIX), is a treatment and diagnostic tool for premalignant and malignant skin cancers. However, to improve drug delivery to deeper skin lesions, more lipophilic ALA esters have been investigated ...
Ryan F Donnelly, Paul A. McCarron, A David Woolfson   +2 more
exaly   +2 more sources