Results 141 to 150 of about 6,641 (157)
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European Journal of Pharmaceutics and Biopharmaceutics, 2006
Topical administration of excess exogenous 5-aminolevulinic acid (ALA) leads to selective accumulation of the potent photosensitiser protoporphyrin IX (PpIX) in neoplastic cells, which can then be destroyed by irradiation with visible light. Due to its hydrophilicity, ALA penetrates deep lesions, such as nodular basal cell carcinomas (BCCs) poorly.
Gilmore, Brendan +5 more
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Topical administration of excess exogenous 5-aminolevulinic acid (ALA) leads to selective accumulation of the potent photosensitiser protoporphyrin IX (PpIX) in neoplastic cells, which can then be destroyed by irradiation with visible light. Due to its hydrophilicity, ALA penetrates deep lesions, such as nodular basal cell carcinomas (BCCs) poorly.
Gilmore, Brendan +5 more
openaire +3 more sources
Journal of Photochemistry and Photobiology B: Biology, 2014
To compare the accumulation of protoporphyrin IX between synoviocytes of patients with rheumatoid arthritis (RA) or osteoarthritis (OA) and cartilage explants (CE) as well as chondrons of patients with OA after the application of 5-aminolevulinic acid (ALA) or its methyl ester (ALA-Me).Samples of synovial and cartilage tissues were obtained from joint ...
Romualdas, Rudys +3 more
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To compare the accumulation of protoporphyrin IX between synoviocytes of patients with rheumatoid arthritis (RA) or osteoarthritis (OA) and cartilage explants (CE) as well as chondrons of patients with OA after the application of 5-aminolevulinic acid (ALA) or its methyl ester (ALA-Me).Samples of synovial and cartilage tissues were obtained from joint ...
Romualdas, Rudys +3 more
openaire +2 more sources
Photochemical & Photobiological Sciences, 2006
Topical PDT treatment of the common skin disease acne vulgaris is now in clinical use. Propionibacterium acnes (P. acnes) is known to play an important role in acne. 5-Aminolevulinic acid (ALA) supplementation leads to an enhanced porphyrin production in the bacteria. Subsequent illumination with light of the proper wavelengths can reduce the number of
Ståle, Ramstad +2 more
openaire +2 more sources
Topical PDT treatment of the common skin disease acne vulgaris is now in clinical use. Propionibacterium acnes (P. acnes) is known to play an important role in acne. 5-Aminolevulinic acid (ALA) supplementation leads to an enhanced porphyrin production in the bacteria. Subsequent illumination with light of the proper wavelengths can reduce the number of
Ståle, Ramstad +2 more
openaire +2 more sources
Archives of Dermatological Research, 2011
Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen.
R N, Manifold, C D, Anderson
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Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen.
R N, Manifold, C D, Anderson
openaire +2 more sources
Journal of Photochemistry and Photobiology B: Biology, 2002
Accumulation of protoporphyrin IX (PpIX) was investigated in normal skin and UV-induced tumours in hairless mice after topical application of a cream containing 2, 8 or 16% of 5-aminolevulinic acid methyl ester (ALA-Me). Higher levels of PpIX were measured in tumours compared to normal skin.
Petras, Juzenas +3 more
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Accumulation of protoporphyrin IX (PpIX) was investigated in normal skin and UV-induced tumours in hairless mice after topical application of a cream containing 2, 8 or 16% of 5-aminolevulinic acid methyl ester (ALA-Me). Higher levels of PpIX were measured in tumours compared to normal skin.
Petras, Juzenas +3 more
openaire +2 more sources
Pharmaceutical Research, 2010
To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT.The skin of 14 healthy volunteers was preteated with MNs.
Patrycja, Mikolajewska +7 more
openaire +3 more sources
To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT.The skin of 14 healthy volunteers was preteated with MNs.
Patrycja, Mikolajewska +7 more
openaire +3 more sources
Photodynamic therapy with aminolevulinic acid or its methyl ester: Which one is superior?
Medical Laser Application: International Journal for Laser Treatment and Research, 2009Barbara Krammer, Thomas Verwanger
exaly