Results 141 to 150 of about 14,105,510 (156)
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The temperature dependence of porphyrin production in Propionibacterium acnes after incubation with 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA)

Photochemical & Photobiological Sciences, 2006
Topical PDT treatment of the common skin disease acne vulgaris is now in clinical use. Propionibacterium acnes (P. acnes) is known to play an important role in acne. 5-Aminolevulinic acid (ALA) supplementation leads to an enhanced porphyrin production in the bacteria. Subsequent illumination with light of the proper wavelengths can reduce the number of
StÃ¥le, Ramstad   +2 more
openaire   +2 more sources

Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic reaction to topical 5-aminolevulinic acid-methyl ester

Archives of Dermatological Research, 2011
Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen.
R N, Manifold, C D, Anderson
openaire   +2 more sources

Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester

Journal of Photochemistry and Photobiology B: Biology, 2002
Accumulation of protoporphyrin IX (PpIX) was investigated in normal skin and UV-induced tumours in hairless mice after topical application of a cream containing 2, 8 or 16% of 5-aminolevulinic acid methyl ester (ALA-Me). Higher levels of PpIX were measured in tumours compared to normal skin.
Petras, Juzenas   +3 more
openaire   +2 more sources

Microneedle Pre-treatment of Human Skin Improves 5-Aminolevulininc Acid (ALA)- and 5-Aminolevulinic Acid Methyl Ester (MAL)-Induced PpIX Production for Topical Photodynamic Therapy Without Increase in Pain or Erythema

Pharmaceutical Research, 2010
To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT.The skin of 14 healthy volunteers was preteated with MNs.
Patrycja, Mikolajewska   +7 more
openaire   +3 more sources

Antitumor Effect of 5-Aminolevulinic Acid Methyl Ester-Mediated Photodynamic Therapy on Local Skin Melanoma and its Metastasized Tumor, in Relation with Antitumor Immunity

Journal of Environmental Pathology, Toxicology and Oncology
Objective of the present study is to investigate the effect of photodynamic therapy (PDT) mediated by 5-aminolevulinic acid methyl ester hydrochloride (ALA-Me) on inhibiting the primary tumor growth and metastasis of melanoma, in relation with antitumor immunity.
Mima, Danzeng   +3 more
exaly   +3 more sources

Photodynamic therapy with aminolevulinic acid or its methyl ester: Which one is superior?

Medical Laser Application: International Journal for Laser Treatment and Research, 2009
Barbara Krammer, Thomas Verwanger
exaly  

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