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Current Microbiology, 2014
Vancomycin-resistant Enterococci (VRE) is a serious concern for public health. Serious infections with VRE have very limited effective antimicrobial therapy, and alternative treatment approaches are highly desirable. One promising approach might be the photodynamic antimicrobial chemotherapy.
Chengcheng, Liu +6 more
semanticscholar +4 more sources
Vancomycin-resistant Enterococci (VRE) is a serious concern for public health. Serious infections with VRE have very limited effective antimicrobial therapy, and alternative treatment approaches are highly desirable. One promising approach might be the photodynamic antimicrobial chemotherapy.
Chengcheng, Liu +6 more
semanticscholar +4 more sources
Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers
Journal of Cancer Research and Clinical Oncology, 2010Photodynamic therapy (PDT) is a new approach to cancer treatment that utilizes photochemical reactions induced by a combination of an oncophilic photosensitizing agent and laser light. With an aim to apply PDT for intraperitoneal disseminated foci of advanced or recurrent ovarian cancers, the present study was conducted to evaluate the antitumor effect
M, Wakui +5 more
openaire +3 more sources
Comparison of the uptake of 5-aminolevulinic acid and its methyl ester in keratinocytes and skin
Naunyn-Schmiedeberg's Archives of Pharmacology, 2012Photodynamic therapy is widely used in the treatment of superficial skin cancers. 5-Aminolevulinic acid (ALA) and its methylated form, methyl-ALA (MAL), are frequently used as precursors to photosensitizing substances. Nevertheless, the mechanism of the uptake of ALA and MAL in keratinocytes and of their skin penetration is still controversial.
R, Schulten +3 more
openaire +3 more sources
Ultrasound in Medicine & Biology, 2018
Sonodynamic therapy (SDT) is emerging as new atherosclerosis treatment. The use of gold nanoparticles (AuNPs) as the vehicle for a sensitizer delivery improves reactive oxygen species formation. In this study, methyl ester of aminolevulinic acid (MALA) gold nanoparticles (MALA:AuNPs) functionalized with polyethylene glycol (PEG) were synthesized by ...
Karina de Oliveira Gonçalvez +2 more
openaire +3 more sources
Sonodynamic therapy (SDT) is emerging as new atherosclerosis treatment. The use of gold nanoparticles (AuNPs) as the vehicle for a sensitizer delivery improves reactive oxygen species formation. In this study, methyl ester of aminolevulinic acid (MALA) gold nanoparticles (MALA:AuNPs) functionalized with polyethylene glycol (PEG) were synthesized by ...
Karina de Oliveira Gonçalvez +2 more
openaire +3 more sources
Archives of Dermatological Research, 2011
Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen.
R N, Manifold, C D, Anderson
openaire +3 more sources
Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen.
R N, Manifold, C D, Anderson
openaire +3 more sources
Iontophoretic delivery of 5-aminolevulinic acid and its methyl ester using a carbopol gel as vehicle
Journal of Controlled Release, 2004The aim of this study was to evaluate a Carbopol gel as a vehicle for iontophoretic delivery of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA). The formulation was characterized rheologically and the passive diffusion of ALA and m-ALA in the gels was measured.
Nadia, Merclin +2 more
openaire +3 more sources
Gynecologic Oncology, 2006
In the past, treating vulvar Paget's disease through surgery has resulted in a high recurrence rate of the disease. Photodynamic therapy (PDT) using 5-aminolevulinic acid (5 ALA) is an effective treatment for some conditions such as Bowen's disease, subsets of basal cell carcinomas and vulvar carcinoma.
F, Raspagliesi +6 more
openaire +3 more sources
In the past, treating vulvar Paget's disease through surgery has resulted in a high recurrence rate of the disease. Photodynamic therapy (PDT) using 5-aminolevulinic acid (5 ALA) is an effective treatment for some conditions such as Bowen's disease, subsets of basal cell carcinomas and vulvar carcinoma.
F, Raspagliesi +6 more
openaire +3 more sources