Results 141 to 150 of about 3,224 (171)

Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic reaction to topical 5-aminolevulinic acid-methyl ester

Archives of Dermatological Research, 2011
Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen.
R N, Manifold, C D, Anderson
openaire   +2 more sources

A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer

International Journal of Oncology, 2003
The use of 5-aminolevulinic acid and its esters to induce endogenous porphyrins for the purpose of detection of epithelial cancers is being studied extensively in many centres around the world. The challenge is to prepare an efficacious formulation for the purpose of cancer detection.
Vanaja, Manivasager, Paul Wan Sia, Heng, Jinsong, Hao, Wei, Zheng, Khee Chee, Soo, Malini, Olivo   +5 more
openaire   +2 more sources

Induction of protoporphyrin IX in patient-derived synoviocytes, cartilage explants and chondrons after application of 5-aminolevulinic acid or its methyl ester

Journal of Photochemistry and Photobiology B: Biology, 2014
To compare the accumulation of protoporphyrin IX between synoviocytes of patients with rheumatoid arthritis (RA) or osteoarthritis (OA) and cartilage explants (CE) as well as chondrons of patients with OA after the application of 5-aminolevulinic acid (ALA) or its methyl ester (ALA-Me).Samples of synovial and cartilage tissues were obtained from joint ...
Romualdas, Rudys, Jaroslav, Denkovskij, Gailutė, Kirdaitė, Saulius, Bagdonas   +3 more
openaire   +2 more sources

Iron mobilization by succinylacetone methyl ester in rats. A model study for hereditary tyrosinemia and porphyrias characterized by 5-Aminolevulinic acid overload

Free Radical Research, 2000
Accumulation of 5-aminolevulinic acid (ALA) is an event characteristic of porphyrias that may contribute to their pathological manifestations. To investigate effects of ALA independent of porphyrin accumulation we treated rats with the methyl ester of succinylacetone, an inhibitor of 5-aminolevulinic acid dehydratase that accumulates in the porphyric ...
M E, Rocha, B, Bandy, C A, Costa, M P, de Barros, A M, Pinto, E J, Bechara   +5 more
openaire   +2 more sources

The temperature dependence of porphyrin production in Propionibacterium acnes after incubation with 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA)

Photochemical & Photobiological Sciences, 2006
Topical PDT treatment of the common skin disease acne vulgaris is now in clinical use. Propionibacterium acnes (P. acnes) is known to play an important role in acne. 5-Aminolevulinic acid (ALA) supplementation leads to an enhanced porphyrin production in the bacteria. Subsequent illumination with light of the proper wavelengths can reduce the number of
Ståle, Ramstad, Nguyen, Le Anh-Vu, Anders, Johnsson   +2 more
openaire   +2 more sources

Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester

Journal of Photochemistry and Photobiology B: Biology, 2002
Accumulation of protoporphyrin IX (PpIX) was investigated in normal skin and UV-induced tumours in hairless mice after topical application of a cream containing 2, 8 or 16% of 5-aminolevulinic acid methyl ester (ALA-Me). Higher levels of PpIX were measured in tumours compared to normal skin.
Petras, Juzenas, Soraya, Sharfaei, Johan, Moan, Robert, Bissonnette   +3 more
openaire   +2 more sources

In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch

European Journal of Pharmaceutics and Biopharmaceutics, 2006
Topical administration of excess exogenous 5-aminolevulinic acid (ALA) leads to selective accumulation of the potent photosensitiser protoporphyrin IX (PpIX) in neoplastic cells, which can then be destroyed by irradiation with visible light. Due to its hydrophilicity, ALA penetrates deep lesions, such as nodular basal cell carcinomas (BCCs) poorly.
Gilmore, Brendan, McCarron, Paul, Morrow, Desmond, Murphy, Diarmaid, Woolfson, David, Donnelly, Ryan   +5 more
openaire   +3 more sources

Microneedle Pre-treatment of Human Skin Improves 5-Aminolevulininc Acid (ALA)- and 5-Aminolevulinic Acid Methyl Ester (MAL)-Induced PpIX Production for Topical Photodynamic Therapy Without Increase in Pain or Erythema

Pharmaceutical Research, 2010
To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT.The skin of 14 healthy volunteers was preteated with MNs.
Patrycja, Mikolajewska, Ryan F, Donnelly, Martin J, Garland, Desmond I J, Morrow, Thakur Raghu Raj, Singh, Vladimir, Iani, Johan, Moan, Asta, Juzeniene   +7 more
openaire   +3 more sources

Tumour fatty acid metabolism in the context of therapy resistance and obesity

Nature Reviews Cancer, 2021
Andrew J Hoy, Shilpa R Nagarajan, Lisa M Butler   +2 more
exaly  

<title>Clearance of protoporphyrin IX from mouse skin after topical application of 5-aminolevulinic acid and its methyl ester</title>

SPIE Proceedings, 1999
Petras Juzenas, Roar Sorensen, Vladimir Iani, Johan Moan   +3 more
openaire   +1 more source