Results 91 to 100 of about 11,853,684 (309)

The hepatotoxicity of γ-radiation synthesized 5-fluorouracil nanogel versus 5-fluorouracil in rats model

International Journal of Immunopathology and Pharmacology
Introduction: The clinical use of 5-fluorouracil (5-FU), a routinely used chemotherapy medication, has a deleterious impact on the liver. Therefore, it is necessary to find a less harmful alternative to minimize liver damage.
Wael EM Barakat, Fatma SM Moawed, Esraa SA Ahmed, Omayma AR Abo-Zaid   +3 more
doaj   +1 more source

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita, Takeru Matsuda, Junko Mukohyama, Ryohei Sasaki, Yoshihiro Kakeji   +4 more
wiley   +1 more source

5-Fluorouracil

, 2019
Inelastic Neutron Scattering spectrum of 5-Fluorouracil, C4H3FN2O2, measured on the TOSCA instrument.
Tan, J-C.
core   +1 more source

Molecular mechanism of Xanthotoxol against gastric cancer: A comprehensive study integrating network pharmacology, computer simulations, and experimental validation

Animal Models and Experimental Medicine, EarlyView.
Our study systematically explored the anti‐gastric cancer (GC) mechanism of Xanthotoxol (Xan), a natural active phytochemical, using an integrated strategy of network pharmacology, molecular simulation, and experimental validation. First, we identified 39 hub genes associated with gastric cancer using weighted gene co‐expression network analysis (WGCNA)
Yi Yang, Yu‐Hua Du, Chuang Song, Lan‐Nv Ma, Lin Luo, De‐Xu Xu, Xiao‐Yan Ma, Zi‐Ying Zhou, Yi Nan, Yi Yang, Ling Yuan   +10 more
wiley   +1 more source

Intralesional 5 fluorouracil in the management of hypertrophic oculofacial scar

Indian Journal of Ophthalmology. Case Reports
A 40-year-female came with chief complaints of scar on the lateral side of the right eye which was extending from lateral canthus to the inferior orbital rim associated with pain and redness over scar.
Gunjan Rathi, Rutuja Gawande, Nikhilesh Wairagade   +2 more
doaj   +1 more source

Wernicke’s Encephalopathy in Colon Cancer

Case Reports in Oncology, 2010
Wernicke’s syndrome, caused by thiamine deficiency, is most commonly associated with alcoholism but can also occur in patients who are malnourished or have malabsorption of nutrients for other reasons. Since the classic triad of encephalopathy, nystagmus
Berrin Papila, Ozcan Yildiz, Deniz Tural, Sakir Delil, Zehra Isik Hasiloglu, Fadil Ayan, Cigdem Papila   +6 more
doaj   +1 more source

Cardiotoxicity and cancer therapy [PDF]

, 2014
A fundamental concept of treatment is to do no harm. However, with cancer treatment this is not always possible. Chemotherapy is associated with cardiovascular (CV) complications.1,2 This risk is even greater in the elderly patients and patients with ...
Mikhailidis, DP, Vasiliadis, I, Kolovou, G   +2 more
core  

Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation

, 2019
Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable ...
R.B. Callado (6402560), N.M.N. Alencar (6402572), D.V.T. Wong (6402545), A.P.M. Santana (6402548), C.A.A. Silva (6402563), C.D.H. Lopes (6402566), R.C.P. Lima-Júnior (6402575), C.R.N. Barbosa (6402557), S.C.M. Barbosa (6402539), G.A.C. Brito (6402569), V.B.M. Pereira (6402542), L.L. Carvalho (6402554), L.T. Lucetti (6402551)   +12 more
core   +1 more source

Physical pegylation enhances the cytotoxicity of 5-fluorouracil-loaded PLGA And PCL nanoparticles. [PDF]

, 2019
Purpose : The main goal of this study is to evaluate the impact of physical incorporation of polyethylene glycol (PEG) into 5-fluorouracil (5-FU)-loaded polymeric nanoparticles (NPs).
Yassin, Alaa Eldeen Bakry, Hussain, Tajamul, A Alsarra, Ibrahim, Badran, Mohamed M., Kumar, Ashok, Ashour, Abdelkader Elbadawy Abbas   +5 more
core   +1 more source

Zebrafish xenograft models as a fast platform for metastasis diagnosis and cisplatin response of head and neck squamous cell carcinoma

Animal Models and Experimental Medicine, EarlyView.
A zebrafish xenograft model accurately distinguishes metastatic from non‐metastatic HNSCC and recapitulates cisplatin sensitivity/resistance patterns. Using patient‐derived tumors, it predicts individual therapeutic responses, offering a rapid, clinically applicable platform for guiding personalized treatment. Abstract Background Head and neck squamous
Lu Chen, Shu Sun, Yujia Liu, Liehao Jiang, Cuiyun Wu, Ting Liu, Yujiao Zhao, Yuwei Liu, Lu Liu, Qi Wang, Xiaowei Zheng, Ping Huang   +11 more
wiley   +1 more source