Results 101 to 110 of about 11,853,684 (309)
Synthesis and Bioevaluation of 5-Fluorouracil Derivatives
Molecules, 2007 A series of six novel 5-fluorouracil derivatives 1-6 were synthesized and theirstructures confirmed by 1H- and 13C-NMR, MS and elemental analysis. The preliminary invitro antitumor activities against B16, K562 and CHO cells and the in vivo inhibitions ...
Chao-Jie Wang +5 more
doaj +1 more source
Non-coding RNA ResearchCholangiocarcinoma is one of the most lethal human cancers, and chemotherapy failure is a major cause of recurrence and poor prognosis. We previously demonstrated that miR-200 family members are downregulated in clinical samples of cholangiocarcinoma and
Feng Peng +10 more
doaj +1 more source
Asian Journal of Pharmaceutical Sciences, 2017 The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery systems were widely used to deliver chemotherapeutic drugs.
Li Sun +7 more
doaj +1 more source
Solution Structures of 5-Fluorouracil-Substituted DNA and RNA Decamer Duplexes†
, 2016 The structures in solution of eight oligonucleotide duplexes each containing either zero, one, or two 5-fluorodeoxyuridine (FdUrd) or 5-fluorouridine (FUrd) nucleosides were determined by the combined use of NMR spectroscopy, restrained molecular ...
William H. Gmeiner (1267275) +2 more
core +1 more source
Magnetic field triggerable macroporous PDMS sponge loaded with an anticancer drug, 5-fluorouracil
, 2021 This study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl
Kejing Shi (4467814) +6 more
core
British Journal of Clinical Pharmacology, EarlyView.Aims Predetermined treatment duration limits (PTDLs) are often used by Taiwan's National Health Insurance Administration to contain healthcare costs, but they may compromise patient outcomes. Therefore, we studied Taiwan's 2017 extension of the bevacizumab PTDL from 24 to 36 weeks in metastatic colorectal cancer (mCRC) to evaluate whether prolonged ...
Wei‐Ming Huang +6 more
wiley +1 more source
Neuropsychiatric complications associated with 5 fluorouracil chemotherapy: a narrative review
The Egyptian Journal of Neurology, Psychiatry and NeurosurgeryNeuropsychiatric toxicity related to 5-fluorouracil (5-FU) chemotherapy is an uncommon but clinically significant adverse effect that is frequently underrecognized.
Tushar Jassal +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton +8 more
wiley +1 more source
Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
BMEMat, EarlyView.Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim +9 more
wiley +1 more source