Results 121 to 130 of about 8,527,959 (316)

Acute granulomatous iritis following 5 fluorouracil therapy for failed trabeculectomy

Indian Journal of Ophthalmology, 1991
We are reporting a case which developed idiosyncratic anterior granulomatous uveitis following a single dose of subconjunctival 5 Fluorouracil. This has not been previously reported anywhere in the world.
Mohan Madan, Kumar Harsh, Rana Sandeep
doaj  

5-Fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer

, 2012
Original researchThis work aimed to develop a new therapeutic approach to increase the efficacy of 5-fluorouracil (5-FU) in the treatment of advanced or recurrent colon cancer.
Alvarez, Pablo J, Arias, José L, Melguizo, Consolación, Ruiz, M Adolfina, Caba, Octavio, Luque, Raquel, Segura, Ana, Aránega, Antonia, Ortiz, Raúl, Prados, José   +9 more
core   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil

, 2017
Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with ...
Gerly Anne de Castro Brito (562850), Renata Ferreira de Carvalho Leitão (2150548), Karoline Saboia Aragão (5110952), Marcos Rabelo de Freitas (4654312), Viviane Carvalho da Silva (5110943), Carlos Wagner de Souza Wanderley (5110940), Gildenio Estevam Freire (5110949), Conceição da Silva Martins (5110946)   +7 more
core   +1 more source

Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta‐Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steatotic liver disease (SLD) is an unrecognized complication after pancreaticoduodenectomy (PD) and may affect nutrition and long‐term recovery. This meta‐analysis estimated the incidence of SLD after PD and identified its clinical and surgical risk factors.
Ronnakorn Kongsakon, Wasit Wongtrakul, Khemajira Karaketklang, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya   +4 more
wiley   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Porokeratoma treated with topical 5% 5-fluorouracil cream

International Journal of Women's Dermatology, 2021
Steve S. Li, BA, Leigh A. Compton, MD, PhD, Kathleen M. Nemer, MD   +2 more
doaj   +1 more source

Image_1_Co-treatment With BGP-15 Exacerbates 5-Fluorouracil-Induced Gastrointestinal Dysfunction.TIF

, 2019
Gastrointestinal (GI) side-effects of chemotherapy present a constant impediment to efficient and tolerable treatment of cancer. GI symptoms often lead to dose reduction, delays and cessation of treatment. Chemotherapy-induced nausea, bloating, vomiting,
Raquel Abalo (6679334), Emma Rybalka (679112), Joel C. Bornstein (6679337), Aaron C. Petersen (6679331), Rachel M. McQuade (5374466), Maryam Al Thaalibi (6679328), Kulmira Nurgali (799081)   +6 more
core   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Cytotoxic Effects of Silibinin in Combination with 5-Fluorouracil on HT29 Colorectal Cancer Cells [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان
Background and Aim: Colorectal cancer is one of the most common types of cancer in the world, causing many deaths worldwide each year. 5-Fluorouracil is the first choice for the treatment of this type of cancer.
Bahman Moradi Poodeh
doaj