Results 141 to 150 of about 11,853,684 (309)

Complications associated with accelerated 5-fluorouracil (5-Fu) infusion

Oncology in Clinical Practice
Małgorzata B. Radom, Aneta L. Zygulska, Piotr J. Wysocki   +2 more
doaj   +1 more source

Fertility counseling and preservation considerations in patients with gynecologic and non‐gynecologic BRCA and Lynch‐associated malignancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Lynch syndrome and BRCA‐mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer ...
Anna Weimer, Nadeem Abu‐Rustum, David Mutch, Mauricio Cuello, Angélica Fletcher, Hextan Y. S. Ngan, Nozomu Yanaihara, Rene Pareja, Christina Fotopoulou, Kenneth Ruzindana, Ka Yu Tse, Yana Zou, Neerja Bhatla, Ting‐Chang Chang, Munanchiso Ndukwe Iheme Jr, Jalid Sehouli, Nicole Conchin, Eva Chalas, Sarikapan Wilailak, Barbara Schmalfeldt, Alexander B. Olawaiye   +20 more
wiley   +1 more source

Synthesis of 5-Fluorouracil Derivatives as Possible Mutual Prodrugs with Meloxicam and Ibuprofen for Targeting Cancer Tissues

Iraqi Journal of Pharmaceutical Sciences, 2017
In the present study, five derivatives have been designed to be synthesized as possible mutual prodrugs for 5-Fluorouracil (5-FU) and non steroidal anti-inflammatory drugs (NSAIDs) to selectively deliver the drugs into the cancer cells.
Zainab A.H. Dakhel, Mohammed H. Mohammed
doaj  

Preparation of 5-fluorouracil nanoparticles by supercritical antisolvents for pulmonary delivery

, 2010
Pardis Kalantarian1,2, Abdolhosein Rouholamini Najafabadi1, Ismaeil Haririan2, Alireza Vatanara1, Yadollah Yamini3, Majid Darabi1, Kambiz Gilani11Aerosol Research Laboratory and 2Pharmaceutical Laboratory, School of Pharmacy, Tehran University of Medical
Pardis Kalantarian, et al, Abdolhosein Rouholamini Najafabadi, Ismaeil Haririan   +3 more
core  

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy

, 2014
Background & Aims: Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy.
P. Delarue (23366188), K. Wanherdrick (23366155), C. Lepage (23366176), C. Garrido (23366218), A. Lagrange (23366140), R. Soong (23359123), C. Tournigand (23366203), A. Bouvier (17993692), C. Chapusot (23366173), J. Fléjou (23366215), M. Svrcek (23366143), A. Guilloux (23366152), Y. Parc (23366209), D. Biard (23366212), H. Arzouk (23366191), P. Senet (23366185), C. Dorard (21367175), J. Lefèvre (23366206), A. De Thonel (23366164), A. Collura (7582016), A. Taieb (23366158), A. Coquelle (23366197), A. Mews (23322748), B. Iacopetta (23309023), G. Milano (2177086), C. Platell (23317438), J. Selves (23366182), G. Marcion (23366170), C. Lacoste (23366194), A. Duval (23366221), L. Marisa (23366146), L. Bengrine-Lefèvre (23366200), R. Seigneuric (23366167), O. Buhard (23366149), M. Loh (7737329), M. Gaub (23366179), Nikolajs Zeps (23309692), A. Saget (23366161)   +37 more
core  

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Chemotherapy After Resection of Pancreatic Ductal Adenocarcinoma: Impact of Different Regimens in a Real‐World Population

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction The PRODIGE 24/CCTG PA.6‐ trial has shown an overall survival (OS) up to 55 months in patients treated with (modified) 5‐fluorouracil, leucovorin, irinotecan and oxaliplatin ((m)FOLFIRINOX) chemotherapy after resection of pancreatic ductal adenocarcinoma (PDAC). The applicability of these results to a real‐world patient population
N. C. Biesma, G. A. Cirkel, N. Haj Mohammad, M. Los, R. C. Verdonk, I. Q. Molenaar, L. A. Daamen, H. C. van Santvoort   +7 more
wiley   +1 more source

Complete Remission of Superficial Basal Cell Carcinoma Using Automatic Patting System‐Assisted Topical 5‐Fluorouracil Therapy: Preliminary Clinical Evidence

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Topical 5‐fluorouracil (5‐FU) is a validated non‐invasive treatment for superficial basal cell carcinoma (sBCC), but its effectiveness may be limited by suboptimal skin penetration and local toxicity. Objectives To evaluate a galenic 5‐FU formulation delivered with Automatic Patting System (APS)‐assisted transdermal enhancement in ...
Francesco D'Oria, Giulio Foggi, Francesco Piscazzi, Marco Ardigò   +3 more
wiley   +1 more source

Apigenin, Selenium, and Combinations Are Effective in Preventing 5-Fluorouracil Induced Cardiovascular Damage. [PDF]

J Biochem Mol Toxicol
Uslu GA, Uslu H, Çoban TA, Toraman E, Özkaraca M.   +4 more
europepmc   +1 more source