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Studies on the Allergenicity of 5‐Fluorouracil
The Journal of Dermatologic Surgery and Oncology, 1977A recent investigation has suggested that delayed hypersensitivity reactions commonly develop during topical 5‐FU therapy and imply that the mechanism of action of 5‐FU may involve destruction of actinic keratoses by a nonspecific immunological reaction.
J J, Leyden, A M, Kligman
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Effects of 5-Fluorouracil on mRNA
1993Currently, there are a number of studies which suggest that FU can have pronounced effects on mRNA and its metabolism. However, the relevance of these changes to the antitumor effect of FU are still not clear. Generally, the mRNAs which have been studied to date involve those genes which are associated with the TS-directed effects of FU and have ...
B J, Dolnick, X P, Wu
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Bowen's disease and 5-fluorouracil
Journal of the American Academy of Dermatology, 1979Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5 ...
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The mutation of poliovirus by 5-fluorouracil
Virology, 1964Abstract Poliovirus grown in 4 m M 5-fluorouracil (5-FU) at an optimum temperature (36°) becomes more “heat defective”; that is, the ratio of plaques formed at supraoptimal temperatures to plaques formed at 36° (“plating efficiency”) is decreased by a factor of 3–10. The plating efficiency at an infraoptimal temperature (30°) is unchanged.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2001
Many a dose and schedule of single agent of 5-fluorouracil (5-FU) has been evaluated to improve therapeutic outcome for four decades. No standard or an optimal dose and schedule has been established yet despite intensive clinical, investigation. Since 5-FU seems to have dual, mechanisms of cell kill; DNA and RNA directed cytotoxicity, it is important ...
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Many a dose and schedule of single agent of 5-fluorouracil (5-FU) has been evaluated to improve therapeutic outcome for four decades. No standard or an optimal dose and schedule has been established yet despite intensive clinical, investigation. Since 5-FU seems to have dual, mechanisms of cell kill; DNA and RNA directed cytotoxicity, it is important ...
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Enhancement of the Effects of 5-Fluorouracil
19865-Fluorouracil (5-FU) is one of the few anticancer agents that has been developed on a rational basis [10]. Although it has been clinically used since the late 1950s, 5-FU has recently attracted new interest because of two developments: 1. Methods have been developed which allow the detection of small amounts of 5-FU and most of its metabolites.
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