Results 251 to 260 of about 175,639 (315)
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Lacrimation and 5-Fluorouracil
Annals of Internal Medicine, 1978Excerpt To the editor: Recently Haidak, Hurwitz, and Yeung (1) reported in your journal that excessive lacrimation occurred in six patients receiving weekly injections of 5-fluorouracil during a pe...
N, Christophidis +3 more
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Cardiotoxicity of 5-Fluorouracil
Tumori Journal, 1980A case is reported of cardiotoxicity during a multiple drug treatment with fluorouracil, vincristine and CCNU in a patient with a large bowel cancer without any precedent history of heart disease. The patient had chest pain, with an altered ECG and increased serum levels of αHBDH.
T, Gamucci, G, Zampa
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Trabeculectomy with 5‐fluorouracil
Acta Ophthalmologica, 1991Abstract The effect of subconjunctival injection of 5‐fluorouracil (5‐FU) after trabeculectomy was studied retrospectively in 205 eyes of 168 patients. A life table analysis of the surgical outcome was based on the type of glaucoma and age related differences, and a comparison was made with patients who had trabeculectomy without subconjunctival 5‐FU ...
J, Watanabe +3 more
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Myocardiotoxicity of 5 Fluorouracil
Intensive Care Medicine, 1988We report a case of specific myocardiotoxicity due to 5 F.U. not previously described in man. A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U. and cis-platinum. Dopamine was necessary to maintain blood pressure. Two-D echocardiography and a right heart catheterisation confirmed the
B, Coronel +4 more
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Cardiotoxicity of 5-Fluorouracil
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2006Cardiac side effects of the cytostatic agent 5-fluorouracil (5-FU) have an incidence of 1.2-7.6%. Potentially, arrhythmias, myocardial infarction and sudden cardiac death could occur. Life-threatening cardiotoxicity is rarely observed with a frequency
P, Alter +4 more
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Desensitization to 5-Fluorouracil
Allergy and Asthma Proceedings, 1999Anaphylactic reactions to 5-fluorouracil (5-FU) are uncommon. We report a 40-year-old female with adenocarcinoma of the ovary who had two reactions immediately after being infused with 5-FU. The second reaction occurred despite prophylaxis with steroids and antihistamines.
T, Eppinger, K, Sperber
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Gynecologic Oncology, 1990
Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
D H, Moore, W C, Fowler, L S, Crumpler
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Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
D H, Moore, W C, Fowler, L S, Crumpler
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Immunosuppression by 5-fluorouracil
Cancer, 1970Twelve patients with neoplasia undergoing therpay with 5-fluorouracil (5-FU) were immunized with Escherichia coli Vi antigen and tetanus toxoid to test the primary and secondary humoral immune responses. Skin sesitization was attempted with 2,4-dinitrochlorobenzene, and a battery of conmon microbial skin tests were applied during and after therapy ...
M S, Mitchell, R C, DeConti
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The Prodrugs of 5-Fluorouracil
Current Medicinal Chemistry-Anti-Cancer Agents, 2002Although 5-fluorouracil (FU) was first introduced in 1957, it remains an essential part of the treatment of a wide range of solid tumors. FU has antitumor activity against epithelial malignancies arising in the gastrointestinal tract, breast as well as the head and neck, with single-agent response rates of only 10-30%.
M, Malet-Martino +2 more
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General Pharmacology: The Vascular System, 1998
1. Primary and secondary resistance to the widely used antimetabolite 5-fluorouracil (5-FU) are common phenomena in cancer chemotherapy. Because 5-FU still remains the agent of choice in the treatment of, for example, colorectal cancer, circumvention of resistance is of vital importance. 2.
R M, Mader, M, Müller, G G, Steger
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1. Primary and secondary resistance to the widely used antimetabolite 5-fluorouracil (5-FU) are common phenomena in cancer chemotherapy. Because 5-FU still remains the agent of choice in the treatment of, for example, colorectal cancer, circumvention of resistance is of vital importance. 2.
R M, Mader, M, Müller, G G, Steger
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