Results 231 to 240 of about 175,639 (315)

TPGS and CS-Surface-Modified DPPC Liposomes Coloaded with Docetaxel and 5‑Fluorouracil: A Potential Avenue for Enhanced Colorectal Cancer Therapy. [PDF]

ACS Omega
Alomrani AH, Badran MM, Bin Duhaim T, Alobid S, Qamar W.   +4 more
europepmc   +1 more source

Prognostic Value of Pathological Response After Conversion Therapy and Salvage Surgery in Unresectable Hepatocellular Carcinoma

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims To evaluate the prognostic significance of pathological response in patients with initially unresectable hepatocellular carcinoma (uHCC) who underwent salvage resection after successful conversion with lenvatinib, anti‐PD‐1 antibodies, and locoregional therapy (LPLRT).
Qi‐Yu Chi, Xiao‐Di Gao, Mi Wang, Quan‐Yuan Liu, Yong‐Yi Zeng, Lan‐Fang Yang, Zi‐Jian Liu, Shuang‐Jia Wang, Shan‐Geng Weng, Zhi‐Bo Zhang   +9 more
wiley   +1 more source

The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats. [PDF]

Front Surg
Chernyshenko T, Polkin R, Ashyrov M, Shepelev V, Goncharuk R.   +4 more
europepmc   +1 more source

Treatment landscape from first‐ to third‐line therapy and quality of life data of patients with pancreatic cancer from the prospective German PARAGON (Platform for Outcome, Quality of Life, and Translational Research on Pancreatic Cancer) registry (IKF‐PARAGON study)

International Journal of Cancer, Volume 158, Issue 10, Page 2560-2570, 15 May 2026.
What's New? Pancreatic cancer often is diagnosed at advanced stages. As a result, treatment regimens frequently are aggressive, with substantial side effects that impact quality of life (QoL). This study examined the treatment landscape, from neoadjuvant therapy to palliative care, in the context of QoL among pancreatic cancer patients in Germany. Most
Thorsten O. Goetze, Salah‐Eddin Al‐Batran, Ruediger Liersch, Lars Scheuer, Thomas Goehler, Ulrich Kaiser, Claudio Denzlinger, Stephan Brandl, Daniel Pink, Jens Uhlig, Michael Maasberg, Maria Loose, Marina Schaaf, Disorn Sookthai, Bianca Zäpf, Claudia Pauligk, Timursah Habibzade, Ralf‐Dieter Hofheinz, Christine Koch, for the AIO Study Group   +19 more
wiley   +1 more source

Response to the Letter to the Editor: Unlocking Better Keloid Treatment: Corticosteroid, 5-Fluorouracil, and Hyaluronidase vs. Corticosteroid Alone: A Randomized Comparative Study. [PDF]

Health Sci Rep
Ehsani A, Lotfi F, Firooz A, Ehsani A, Razavi Z, Ansari MS, Nourmohammadpour P, Sima F, Mohammadabadi MK, Rahimnia A.   +9 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Esketamine Enhances the Chemosensitivity of Colorectal Adenocarcinoma Cells to 5-Fluorouracil via AMPK/mTOR/HMMR Signaling Pathway. [PDF]

Oncol Res
Feng Y, Tong P, Fu S, Lu X, Zheng L, Lai J, Lai R.   +6 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, Volume 16, Issue 5, Page 1020-1029, May 2026.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Correction: Mitomycin, 5-fluorouracil, and radiotherapy for anal canal cancer in a patient undergoing hemodialysis: a case report. [PDF]

Int Cancer Conf J
Ozawa Y.
europepmc   +1 more source

Predictive value of primary gross tumor volume measured by MRI in response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background Neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally advanced rectal cancer (LARC), yet individual tumor regression response varies considerably. Purpose This study aimed to identify clinical factors linked to tumor regression grade (TRG) after nCRT in LARC and to evaluate MRI‐measured primary gross tumor volume (
Junbiao Li, Yuduo Wu, Shaoping Ye, Cuiying Fan, Yanping Lin, Dianhua Yang, Xiaoyi Xia, Yajing Kang, Dehao Liu, Junxin Wu   +9 more
wiley   +1 more source