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The spectrum of 5‐fluorouracil cardiotoxicity
Medical Journal of Australia, 1994To report three cases of cardiotoxicity related to the administration of 5-fluorouracil (5-FU) in patients with cancer.Three patients with gastrointestinal malignancies were being treated with combined radiotherapy and chemotherapy regimens. Two patients developed myocardial ischaemia and the other a ventricular arrhythmia in association with 5-FU ...
S A, McLachlan +4 more
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5-Fluorouracil Metabolizing Enzymes
2003The uracil analog 5-fluorouracil (5-FU) is used as part of combination therapy for the treatment of breast, head/neck, and gastrointestinal malignancies, and has single-agent activity in colorectal cancer. 5-FU itself is inactive and requires intracellular conversion to form cytotoxic nucleotides (1). Several cellular targets for fluoropyrimidines have
H L, McLeod, L H, Milne, S J, Johnston
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Effects of 5-Fluorouracil on mRNA
1993Currently, there are a number of studies which suggest that FU can have pronounced effects on mRNA and its metabolism. However, the relevance of these changes to the antitumor effect of FU are still not clear. Generally, the mRNAs which have been studied to date involve those genes which are associated with the TS-directed effects of FU and have ...
B J, Dolnick, X P, Wu
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Bowen's disease and 5-fluorouracil
Journal of the American Academy of Dermatology, 1979Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5 ...
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The metabolism and pharmacology of 5‐fluorouracil
Journal of Surgical Oncology, 1971Abstract5‐Fluorouracil (5‐FU) is a chemotherapeutic agent, which is administered systemically for the palliative treatment of certain neoplastic diseases. Because 5‐FU is a potent antimetabolite, it is recommended that the drug be given only by physicians experienced in the use of antimetabolites.
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Enhancement of the Effects of 5-Fluorouracil
19865-Fluorouracil (5-FU) is one of the few anticancer agents that has been developed on a rational basis [10]. Although it has been clinically used since the late 1950s, 5-FU has recently attracted new interest because of two developments: 1. Methods have been developed which allow the detection of small amounts of 5-FU and most of its metabolites.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2001
Many a dose and schedule of single agent of 5-fluorouracil (5-FU) has been evaluated to improve therapeutic outcome for four decades. No standard or an optimal dose and schedule has been established yet despite intensive clinical, investigation. Since 5-FU seems to have dual, mechanisms of cell kill; DNA and RNA directed cytotoxicity, it is important ...
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Many a dose and schedule of single agent of 5-fluorouracil (5-FU) has been evaluated to improve therapeutic outcome for four decades. No standard or an optimal dose and schedule has been established yet despite intensive clinical, investigation. Since 5-FU seems to have dual, mechanisms of cell kill; DNA and RNA directed cytotoxicity, it is important ...
openaire +1 more source