Results 41 to 50 of about 107,466 (267)

Histopathological Study of 5−Fluorouracil with and without Folic Acid administration on The Gastric Mucosa of Male Rabbits [PDF]

Al-Rafidain Dental Journal, 2017
Aims : To study the effects of 5−Fluorouracil (5−FU) on the gastric mucosa of rabbits and to evaluate the effect of folic acid (FA) on these effectiveness.
Alhan Daham Hadi Al –Moula
doaj   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Comparative Evaluation of the Therapeutic Efficacy of Microneedling Alone or Microneedling Combined with Topical 5-Fluorouracil In Localized Stable Childhood Vitiligo

Advances in Human Biology, 2016
Aim: The aim of this study was to evaluate and compare the therapeutic efficacy of microneedling and microneedling combined with topical 5- fluorouracil. Materials and Method: Twentyfive patients with localized stable vitiligo were treated in each group.
B C Ghiya, Prasoon Soni, Ankit Kumar Singrodia, Sunny Chhabra, R D Mehta, Jyoti S Bai   +5 more
doaj  

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, EarlyView.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source

Targeting laryngeal cancer cells with 5-fluorouracil and curcumin using mesoporous silica nanoparticles

Technology in Cancer Research & Treatment, 2020
Objective: To explore the inhibitory and synergistic effects of 5-fluorouracil and curcumin on Hep-2 laryngeal cancer cells and clarify the effect of mesoporous silica nanoparticles as drug carriers.
Ding Wang PhD, Dan Yu PhD, Xueshibojie Liu PhD, Qian Wang, Xuyang Chen PhD, Xindan Hu MD, Qiong Wang MD, Chunshun Jin PhD, Lianji Wen PhD, Ling Zhang PhD   +9 more
doaj   +1 more source

β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest

Frontiers in Bioengineering and Biotechnology, 2020
ObjectiveColorectal cancer is a malignant tumor of the digestive system with high morbidity and mortality. 5-fluorouracil remains a widely used chemotherapeutic drug in the treatment of advanced colorectal cancer, but chemotherapy drugs are prone to ...
Ruonan Zhang, Ruonan Zhang, Ruonan Zhang, Ting Pan, Ting Pan, Yu Xiang, Yu Xiang, Mingming Zhang, Mingming Zhang, Jiao Feng, Jiao Feng, Shuiping Liu, Shuiping Liu, Ting Duan, Ting Duan, Peng Chen, Peng Chen, Bingtao Zhai, Bingtao Zhai, Xiaying Chen, Xiaying Chen, Wengang Wang, Wengang Wang, Bi Chen, Bi Chen, Bi Chen, Xuemeng Han, Xuemeng Han, Liuxi Chen, Liuxi Chen, Lili Yan, Lili Yan, Ting Jin, Ting Jin, Ying Liu, Guohua Li, Guohua Li, Xingxing Huang, Xingxing Huang, Wenzheng Zhang, Wenzheng Zhang, Yitian Sun, Yitian Sun, Qiujie Li, Qiujie Li, Qin Zhang, Qin Zhang, Lvjia Zhuo, Lvjia Zhuo, Tian Xie, Tian Xie, Qibiao Wu, Xinbing Sui, Xinbing Sui, Xinbing Sui   +54 more
doaj   +1 more source

Potential Survival Benefit of Neoadjuvant Docetaxel, Cisplatin and 5‐Fluorouracil Therapy in Patients With Esophageal Squamous Cell Carcinoma With Multiple Lymph Node Metastases: A Single‐Institute Propensity Score Analysis

Annals of Gastroenterological Surgery, EarlyView.
Although neoadjuvant chemotherapy with fluorouracil, cisplatin, and docetaxel (NAC‐DCF) is the current standard neoadjuvant regimen for esophageal squamous cell carcinoma, its substantial toxicity underscores the need to identify patients who derive the greatest benefit.
Eiji Higaki, Tetsuya Abe, Hironori Fujieda, Shigenori Kadowaki, Tsutomu Tanaka, Masahiro Tajika, Koji Komori, Seiji Ito, Isao Oze, Kei Muro   +9 more
wiley   +1 more source

Sex‐Based Body Composition Changes in Patients With Rectal Cancer Undergoing Preoperative Chemoradiotherapy: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
This prospective study observed that preoperative chemoradiotherapy for rectal cancer was associated with reductions in body fat and grip strength, which appeared to be more pronounced in female patients. These findings suggest that sex‐sensitive nutritional and exercise support may be beneficial to help maintain muscle mass and physical function ...
Shinya Abe, Hiroaki Nozawa, Kentaro Abe, Yumi Yokota, Shunsuke Hori, Yusuke Taguchi, Mitsutaka Yakabe, Kazuhito Sasaki, Sumito Ogawa, Soichiro Ishihara   +9 more
wiley   +1 more source