Results 41 to 50 of about 8,527,959 (316)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Ameliorative effect of vitamin C against 5-fuorouracil-induced hepatotoxicity in mice: A light and electron microscope study

Journal of Basic and Applied Zoology, 2014
5-Fluorouracil is one of the most widely used chemotherapeutic agents in case of hepatic neoplasms. The object of this study was to determine the effectiveness of vitamin C in alleviating 5-fluorouracil-induced hepatotoxicity in male mice.
Nadia R.A. Abou-Zeid
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Synthesis and in vitro anticancer properties of a novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil

, 2018
A novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil, K11(C4H4FN2O2)2Nd(GeW11O39)2·15H2O (FNdGeW), was synthesized and its structure was characterized by 1H NMR, IR, XRD, and TG-DSC.
Qingyin Wu (4783203), Zengqiang Li (725869), Haibin Liu (403499), Ce Zhao (5183348), Danfeng Zhang (1643638), Baoyang Zhou (5183345)   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters

, 2022
Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C.
Luiz Alberto Lira Soares (3607856), Maria Luiza Diniz de Sousa Lopes (14073330), Edna Maria Silva (14073315), Amanda Lanna Andrade Barbalho (14073321), Iolanda Augusta Fernandes de Matos (14073324), Janaina Carla Barbosa Machado (14073336), Matheus Araujo dos Santos (14073327), Caroline Addison Carvalho Xavier de Medeiros (14073333), Aurigena Antunes de Araújo (14073312), Cristiane Assunção da Costa Cunha Mafra (14073318), Raimundo Fernandes de Araújo (14073339), Magda Rhayanny Assunção Ferreira (7492277), Rubens Maribondo do Nascimento (5528156), Íris do Céu Clara Costa (10399338), Gerlane Coelho Bernardo Guerra (5379341)   +14 more
core   +1 more source

Near‐Infrared Light‐Driven Zn/Au Janus Micromotors for Multiplex SERS Detection of Anticancer Drugs

Advanced Functional Materials, EarlyView.
Zn/Au Janus micromotors, propelled by thermophoretic effects under NIR light, function as active SERS platforms for single and multiplex detection of anticancer drugs. Their dynamic motion enhances analyte exchange at the Au interface, reducing saturation and competitive adsorption, thereby improving sensitivity and extending the linear detection range.
Tijana Maric, Gohar Soufi, Ziqiao Li, Erick Chica, Amran Abdirasheed Ali Jinow, Nada Al‐Roubaï, Noor Ahmed, Yaman Göksel, Anja Boisen   +8 more
wiley   +1 more source

Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

, 2017
Background: 5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats as the experimental model ...
Hsieh, Chen-Hsi;Hou, Mei-Ling;Wang, Li-Ying;Tai, Hung-Chi;Tsai, Tung-Hu;Chen, Yu-Jen, 王儷穎   +1 more
core   +1 more source

Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil [PDF]

, 2019
In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU ...
Ana M. Garcia, Domenico Marson, Evelina Parisi, Ana M. Garcia, Paola Posocco, Silvia Marchesan   +5 more
core   +1 more source