Results 21 to 30 of about 11,853,684 (309)
Insights into the involvement of noncoding RNAs in 5-fluorouracil drug resistance
Tumor Biology, 2017 5-Fluorouracil is a classic chemotherapeutic drug that is widely used to treat various cancers. However, patients often exhibit primary or acquired drug resistance during treatment with 5-fluorouracil chemotherapy.
Jun Deng +4 more
doaj +1 more source
DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report
Pharmaceutics, 2019 5-Fluorouracil remains a foundational component of chemotherapy for solid tumour malignancies. While considered a generally safe and effective chemotherapeutic, 5-fluorouracil has demonstrated severe adverse event rates of up to 30%.
Theodore J. Wigle +3 more
doaj +1 more source
Arquivos de Neuro-Psiquiatria, 2022 Background Anthracyclines-based regimen (5-fluorouracil, doxorubicin, and cyclophosphamide (FAC); cyclophosphamide, epirubicin, and 5-fluorouracil [CEF]) and non-anthracycline based regimens (cyclophosphamide, methotrexate, and 5-fluorouracil [
Mohd Ashif Khan +4 more
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Intraoperative infiltration against topical application of 5-fluorouracil in pterygium treatment
Delta Journal of Ophthalmology, 2017 Purpose The aim of this study was to compare the efficacy and safety of intraoperative infiltration versus topical application of 5-fluorouracil (5-FU) as an adjuvant drug in pterygium treatment.
Basem M Ibrahim, Waled M Nada
doaj +1 more source
Molecular Therapy: Oncolytics, 2023 TG6002 is an oncolytic vaccinia virus expressing FCU1 protein, which converts 5-fluorocytosine into 5-fluorouracil. The study objectives were to assess tolerance, viral replication, 5-fluorouracil synthesis, and tumor microenvironment modifications to ...
Jérémy Béguin +15 more
doaj +1 more source
Capecitabine as second-line treatment for metastatic cholangiocarcinoma: A report of two cases [PDF]
, 2002 Background: The management of recurrent, metastatic cholangiocarcinoma still remains a problem since this tumor entity is classified as chemotherapy-resistant.
Schalhorn, A. +2 more
core +1 more source
Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study
Cancer Communications, 2018 Background 5-Fluorouracil (5-FU) and capecitabine-associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but such cardiotoxicity in Chinese ...
Jianjun Peng +15 more
doaj +1 more source
Can localised 19F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response? [PDF]
, 2010 Background 5-Fluorouracil remains widely used in colorectal cancer treatment more than 40 years after its development. 19F magnetic resonance spectroscopy can be used in vivo to measure 5FU’s half-life and metabolism to cytotoxic fluoronucleotides ...
Griffiths, John R. +17 more
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5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling
MolbankA series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step.
Laura Giraldo-Arroyave +2 more
doaj +1 more source
Gemcitabine: Progress in the treatment of pancreatic cancer [PDF]
, 2001 Unresectable pancreatic cancer has a dismal prognosis with a median survival of 3-5 months in untreated disease. Since the introduction of gemcitabine, pancreatic cancer may no longer be regarded a chemotherapy-resistant tumor.
Heinemann, Volker
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