Results 51 to 60 of about 11,748,335 (151)

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Carbonized polymer dots with aqueous‐stable room‐temperature phosphorescence: Mechanism, matrix engineering, and application

Responsive Materials, EarlyView.
This review focuses on inorganic and organic matrices that enable aqueous‐stable room‐temperature phosphorescence (RTP) in carbonized polymer dots (CPDs). It explains the underlying RTP mechanisms, highlights how matrix engineering provides spatial confinement and bonding interactions to stabilize triplet excitons in water, and demonstrates key ...
Yuhan Hou, Chengyu Zheng, Songyuan Tao, Yuzhuo Wang, Bai Yang   +4 more
wiley   +1 more source

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, EarlyView.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source

Pitfalls in the diagnosis of carcinoid syndrome

Family Medicine & Primary Care Review, 2016
Background . Carcinoid syndrome (CS ) is a rare syndrome, most commonly associated with neuroendocrine neoplasms (NEN s) of the small intestine. Carcinoid syndrome consists of diarrhea, vomiting, abdominal pain, cutaneous flushing, teleangiectasias ...
Dorota Kaczmarska-Turek, Magdalena Pryć, Aleksander Kuś, Mateusz Klukowski, Mikołaj Radziszewski, Marzanna Staszewska-Skurczyńska, Aneta Jańczyk, Katarzyna Dźwiarek, Tomasz Bednarczuk   +8 more
doaj   +1 more source

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

A Comparative Study on Neurochemistry of Cerebrospinal Fluid in Advanced Parkinson's Disease

Neurobiology of Disease, 1999
This study addresses two issues: (1) the comparative neurochemistry of classic tremor type of Parkinson's disease or PD-A and akinetic type of Parkinson's disease or PD-B; and (2) the neurochemistry of levodopa failure syndrome (LDFS).
H. Liu, R.P. Iacono, T. Schoonenberg, S. Kuniyoshi, J. Buchholz   +4 more
doaj   +1 more source

Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid. [PDF]

PLoS ONE, 2012
BACKGROUND: Animal studies have revealed seasonal patterns in cerebrospinal fluid (CSF) monoamine (MA) turnover. In humans, no study had systematically assessed seasonal patterns in CSF MA turnover in a large set of healthy adults.
Jurjen J Luykx, Steven C Bakker, Eef Lentjes, Marco P M Boks, Nan van Geloven, Marinus J C Eijkemans, Esther Janson, Eric Strengman, Anne M de Lepper, Herman Westenberg, Kai E Klopper, Hendrik J Hoorn, Harry P M M Gelissen, Julian Jordan, Noortje M Tolenaar, Eric P A van Dongen, Bregt Michel, Lucija Abramovic, Steve Horvath, Teus Kappen, Peter Bruins, Peter Keijzers, Paul Borgdorff, Roel A Ophoff, René S Kahn   +24 more
doaj   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Differential timing of amino acid and 5-HIAA rhythms in suprachiasmatic hypothalamus

, 1993
In vivo brain microdialysis was used to characterize the daily pattern of extracellular excitatory amino acids (EAA; glutamate and aspartate), glutamine and 5-hydroxyindoleacetic acid (5-HIAA) in the region of the suprachiasmatic nucleus (SCN) in freely
J. L. Blank, J. D. Glass, U. E. Hauser, M. Selim, M. A. Rea   +4 more
core   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source