Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HT<sub>2A/2C</sub> receptor activation with a major role of 5-HT<sub>2A</sub> receptors in the hippocampal CA3 subfield. [PDF]
Chagraoui A +11 more
europepmc +1 more source
Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice. [PDF]
Wu WH +10 more
europepmc +1 more source
Pharmacologic MRI Brain Imaging Studies of Serotonin 5-HT<sub>1</sub> Receptor Agonists in Awake Mice. [PDF]
Brems BM +5 more
europepmc +1 more source
Chenodeoxycholic acid activates the TGR5/TRPA1-5-HT pathway to regulate intestinal motility in breastfed infants and mouse models. [PDF]
Shan Z +6 more
europepmc +1 more source
Explainable Artificial Intelligence (xAI) for 5-HT<sub>2A</sub> Receptor Binding Affinity of New Psychoactive Substances. [PDF]
Schöning V +5 more
europepmc +1 more source
Neurotransmitter 5-HT Further Promotes LL-37-Induced Rosacea-like Inflammation Through HTR3A. [PDF]
Ma H +5 more
europepmc +1 more source
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Regulation of 5-HT Release in the CNS by Presynaptic 5-HT Autoreceptors and by 5-HT Heteroreceptors
2000The amount of serotonin (5-hydroxytryptamine; 5-HT) released from the varicosities of the serotoninergic axon terminals in response to invading action potentials at a given frequency is by no means constant. As generally accepted now, exocytotic release of 5-HT can be significantly modified by presynaptic receptors, i.e.
M. Göthert, E. Schlicker
openaire +1 more source
Recent experimental data, both in animals and the clinic, suggest that drugs selectively interacting with the 5-HT system may reduce alcohol intake. Although the precise mechanisms underlying these drug effects are unknown, it seems that there are at least two pharmacological strategies available, described in this review by Edward Sellers and ...
Sellers, Edward M. +2 more
openaire +3 more sources
The study of 5-hydroxytryptamine (5-HT) system has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Growing evidence suggests that 5-HT is important in learning and memory and all its receptors might be implicated in this.
openaire +2 more sources

