Results 211 to 220 of about 285,668 (244)
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5-HT antagonists and blockade of neuronal (5-HT) receptors on ganglion cells
General Pharmacology: The Vascular System, 1984Potential changes in superior cervical ganglion cells evoked by 5-HT or the nicotinic agonist, dimethyl-phenyl piperazinium (DMPP), were recorded using the sucrose-gap method and a number of putative 5-HT antagonists tested for potency and selectivity. Selective blockade of 5-HT responses was produced by 5-HT itself and, in increasing order of potency,
H L, Nash, D I, Wallis, G, Ash
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Role of Somatodendritic 5‐HT Autoreceptors in Modulating 5‐HT Neurotransmissiona
Annals of the New York Academy of Sciences, 1998ABSTRACT: A very important element controlling serotonin (5‐HT) release throughout the brain is the 5‐HT1A autoreceptor present on the soma and dendrites of 5‐HT neurons since it exerts a negative feedback influence on their firing activity. This 5‐HT1A autoreceptor receives an increased activation by endogenous 5‐HT at the beginning of a treatment ...
P, Blier +4 more
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Expression of 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in the mouse embryo
International Journal of Developmental Neuroscience, 2000AbstractExpression patterns of 5‐HT2A, 5‐HT2B and 5‐HT2C receptors during mouse embryogenesis were investigated using highly specific monoclonal antibodies. Differential and overlapping spatio‐temporal patterns of 5‐HT2A, 5‐HT2B and 5‐HT2C receptor immunoreactivity were observed during active phases of morphogenesis of a variety of embryonic tissues ...
J M, Lauder +3 more
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Life Sciences, 1985
The ability of m-trifluoromethylphenylpiperazine (TFMPP) and an N-substituted derivative, LY 165163 (p-NH2-PE-TFMPP), to discriminate 5-HT-1 binding sites labelled by [3H]5-HT is compared in rat corpus striatum and rat cortex. TFMPP displays at least a 30 fold selectivity for the 5-HT-1b subtype. Furthermore, TFMPP reveals heterogeneity within the 5-HT-
Kenneth B. Asarch +2 more
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The ability of m-trifluoromethylphenylpiperazine (TFMPP) and an N-substituted derivative, LY 165163 (p-NH2-PE-TFMPP), to discriminate 5-HT-1 binding sites labelled by [3H]5-HT is compared in rat corpus striatum and rat cortex. TFMPP displays at least a 30 fold selectivity for the 5-HT-1b subtype. Furthermore, TFMPP reveals heterogeneity within the 5-HT-
Kenneth B. Asarch +2 more
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Platelet Serotonin (5‐HT) and 5‐HT Releasing Factor in Plasma of Migrainous Patients
Headache: The Journal of Head and Face Pain, 1979SYNOPSIS The mean platelet 5‐HT concentration in 24 migrainous patients during headache‐free intervals (580 ± 53.3 ng10 9 platelets, M ± SEM) was similar to that found in 25 healthy persons (550 ± 48.1).
Muck-Šeler, Dorotea +2 more
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Characterisation of heteromeric 5-HT₃ receptors: a focus on the 5-HT₃C and 5-HT₃E subunits
20175-HT₃ receptors are ligand-gated cation channels present in both central and peripheral nervous systems. 5-HT₃ receptor antagonists are used clinically for a range of disorders including irritable bowel syndrome, chemotherapy-induced nausea and depression but have varying efficacy. 5-HT₃ receptors potentially contain five different subunits (A, B, C, D
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Headache: The Journal of Head and Face Pain, 1994
SYNOPSIS Serotonin, or 5‐hydroxytryptamine [5‐HT], is a biogenic amine implicated in controlling feeding behavior, thermoregulation, sexual behavior, and sleep. 5‐HT receptors recognize at least three types of molecular structures: G protein coupled receptors, ligand gated ion channels, and transporters.
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SYNOPSIS Serotonin, or 5‐hydroxytryptamine [5‐HT], is a biogenic amine implicated in controlling feeding behavior, thermoregulation, sexual behavior, and sleep. 5‐HT receptors recognize at least three types of molecular structures: G protein coupled receptors, ligand gated ion channels, and transporters.
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Current Opinion in Pharmacology, 2011
Bone formation and bone resorption, the two processes occurring constantly and in a balanced fashion throughout the skeleton, are regulated by signals as various as local and low range growth factors, hormones, and neuronal outputs. Adding to the long list of molecules involved in these regulations, gut-derived and brain-derived serotonin were recently
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Bone formation and bone resorption, the two processes occurring constantly and in a balanced fashion throughout the skeleton, are regulated by signals as various as local and low range growth factors, hormones, and neuronal outputs. Adding to the long list of molecules involved in these regulations, gut-derived and brain-derived serotonin were recently
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Journal of Psychopharmacology, 1993
The discovery and clinical evolution of 5-HT re-uptake inhibiting drugs are reviewed. From the widespread distribution of 5-HT in bodily systems and the range of effects and side effects reported, it is concluded that these and other drugs active on the 5-HT system are likely to have beneficial effects on a range of other physical conditions coincident
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The discovery and clinical evolution of 5-HT re-uptake inhibiting drugs are reviewed. From the widespread distribution of 5-HT in bodily systems and the range of effects and side effects reported, it is concluded that these and other drugs active on the 5-HT system are likely to have beneficial effects on a range of other physical conditions coincident
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Discriminating between 5-HT₃A and 5-HT₃AB receptors.
British journal of pharmacology, 2014The 5-HT3B subunit was first cloned in 1999, and co-expression with the 5-HT3A subunit results in heteromeric 5-HT₃AB receptors that are functionally distinct from homomeric 5-HT₃A receptors. The affinities of competitive ligands at the two receptor subtypes are usually similar, but those of non-competitive antagonists that bind in the pore often ...
A J, Thompson, S C R, Lummis
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