Results 1 to 10 of about 25,240 (222)
Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors [PDF]
Frontiers in Molecular Neuroscience, 2020 Spaced training is robustly superior to massed training, which is a well-documented phenomenon in humans and animals. However, the mechanisms underlying the spacing effect still remain unclear.
Lizhu Jiang +12 more
doaj +2 more sources
Central Serotonin-2A (5-HT2A) Receptor Dysfunction in Depression and Epilepsy: The Missing Link? [PDF]
Frontiers in Pharmacology, 2015 5-Hydroxytryptamine 2A receptors (5-HT2A-Rs) are G-protein coupled receptors. In agreement with their location in the brain, they have been implicated not only in various central physiological functions including memory, sleep, nociception, eating and ...
Bruno Pierre Guiard +4 more
doaj +3 more sources
Journal of Pharmacological Sciences, 2006 Mutations producing constitutively active G-protein coupled receptors have been found in the pathophysiology of several diseases, implying that inverse agonists at the constitutively active receptors may have preferred therapeutic applications.
Habib Abul Muntasir +4 more
doaj +3 more sources
Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice. [PDF]
J Physiol Sci, 2019 This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) were pre-instrumented with a telemetric probe to measure core body temperature and heart rate prior to experimentation. Vehicle or 5-HT2A antagonist,
Sinh V, Ootsuka Y.
europepmc +4 more sources
Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors [PDF]
Biomolecules & Biomedicine, 2017 Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is used as a nasal decongestant. Studies on lerimazoline are rare, and its pharmacological profile is not completely understood.
Eldina Rizvić +3 more
doaj +2 more sources
5-HT2A receptors modulate dopamine D2-mediated maternal effects. [PDF]
Pharmacol Biochem Behav, 2019 Serotonin 5-HT2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-HT2A receptors may also modulate the D2-mediated maternal effects.
Gao J, Chen L, Li M.
europepmc +4 more sources
Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines [PDF]
Frontiers in PharmacologyBackground4-substituted 2,6-dimethoxyphenethylamines and the corresponding amphetamines (so-called pseudo [Ψ] derivatives) are a hitherto mostly unexplored group of psychedelics.
Karolina E. Kolaczynska +7 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 3,4,5-Trimethoxyphenethylamine (mescaline) is a psychedelic alkaloid found in peyote cactus. Related 4-alkoxy-3,5-dimethoxy-substituted phenethylamines (scalines) and amphetamines (3C-scalines) are reported to induce similarly potent psychedelic effects ...
Karolina E. Kolaczynska +5 more
doaj +1 more source
Overcoming Depression with 5-HT2A Receptor Ligands [PDF]
International Journal of Molecular Sciences, 2023 Depression is a multifactorial disorder that affects millions of people worldwide, and none of the currently available therapeutics can completely cure it. Thus, there is a need for developing novel, potent, and safer agents. Recent medicinal chemistry findings on the structure and function of the serotonin 2A (5-HT2A) receptor facilitated design and ...
Agata Zięba +3 more
openaire +3 more sources
Phytomedicine Plus, 2022 Background: 5-HT2A receptors play an important role in the development and therapy of depression. St. John's wort (SJW) extracts are used in the treatment of depression.
Stefan Aatz +3 more
doaj +1 more source