Results 11 to 20 of about 25,240 (222)

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. [PDF]

Science, 2023
Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE.   +13 more
europepmc   +2 more sources

Serotonin 5-HT2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression

Scientific Reports, 2021
Serotonin 5-HT2 receptors are expressed in many tissues and play important roles in biological processes. Although the 5-HT2A receptor is primarily known for its role in central nervous system, it is also expressed in peripheral tissues.
Bangning Yu, Diana M. Battaglia, Timothy P. Foster, Charles D. Nichols   +3 more
doaj   +1 more source

Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats. [PDF]

PLoS ONE, 2013
Despite common pathophysiological mechanisms, inflammatory and neuropathic pain do not respond equally to the analgesic effect of antidepressants, except for selective serotonin reuptake inhibitors (SSRIs), which show a limited efficacy in both ...
Anne-Sophie Wattiez, Xavier Pichon, Amandine Dupuis, Alejandro Hernández, Anne-Marie Privat, Youssef Aissouni, Maryse Chalus, Teresa Pelissier, Alain Eschalier, Philippe Marin, Christine Courteix   +10 more
doaj   +1 more source

Antagonist Functional Selectivity: 5-HT2A Serotonin Receptor Antagonists Differentially Regulate 5-HT2A Receptor Protein Level In Vivo [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2011
Dysregulation of the 5-HT2A receptor is implicated in both the etiology and treatment of schizophrenia. Although the essential role of 5-HT2A receptors in atypical antipsychotic drug actions is widely accepted, the contribution of 5-HT2A down-regulation to their efficacy is not known.
Prem N, Yadav, Wesley K, Kroeze, Martilias S, Farrell, Bryan L, Roth   +3 more
openaire   +2 more sources

Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats

Frontiers in Neuroscience, 2023
IntroductionPsilocybin is one of the most extensively studied psychedelic drugs with a broad therapeutic potential. Despite the fact that its psychoactivity is mainly attributed to the agonism at 5-HT2A receptors, it has high binding affinity also to 5 ...
Filip Tylš, Filip Tylš, Čestmír Vejmola, Čestmír Vejmola, Vlastimil Koudelka, Václava Piorecká, Václava Piorecká, Lukáš Kadeřábek, Marcel Bochin, Marcel Bochin, Tomáš Novák, Tomáš Novák, Martin Kuchař, Martin Kuchař, Zdeňka Bendová, Martin Brunovský, Martin Brunovský, Jiří Horáček, Jiří Horáček, Tomáš Pálení ček, Tomáš Pálení ček   +20 more
doaj   +1 more source

Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. [PDF]

PLoS ONE, 2017
Seven healthy volunteers underwent PET scans with [18F]altanserin and [11C]FLB 457 for 5-HT2A and D2 receptors, respectively. As a measure of receptor density, a binding potential (BP) was calculated from PET data for 76 cerebral cortical regions.
Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang, Makiko Yamada, Makoto Higuchi, Yoshiro Okubo, Tetsuya Suhara   +11 more
doaj   +1 more source

PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization

Frontiers in Endocrinology, 2021
Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano, Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Takanobu Nakazawa, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto   +12 more
doaj   +1 more source

Htr2a gene and 5-HT_2A receptor expression in the cerebral cortex studied using genetically modified mice

Frontiers in Neuroscience, 2010
Serotonin receptors of the 5-HT2A subtype are robustly expressed in the cerebral cortex where they have been implicated in the pathophysiology and therapeutics of mental disorders and the actions of hallucinogens.
Rodrigo Andrade, Elaine T Weber
doaj   +1 more source

The Influence of Hyperactivity of the Hypothalamic-pituitary-adrenal Axis and Hyperglycemia on the 5-HT2A Receptor-mediated Wet-dog Shake Responses in Rats [PDF]

, 2007
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-
Amano, Manabu, Araki, Hiroaki, Gomita, Yutaka, Kawasaki, Hiromu, Kitamura, Yoshihisa, Suemaru, Katsuya, Umeda, Yuichi, Yamaguchi, Takumi   +7 more
core   +1 more source

Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines

Frontiers in Pharmacology, 2019
Background: 2,4,5-Trimethoxyamphetamine (TMA-2) is a potent psychedelic compound. Structurally related 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamine congeners (2C-O derivatives) have been described but their pharmacology is mostly ...
Karolina E. Kolaczynska, Dino Luethi, Dino Luethi, Daniel Trachsel, Marius C. Hoener, Matthias E. Liechti   +5 more
doaj   +1 more source