Results 81 to 90 of about 25,240 (222)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Journal of Pharmacological Sciences, 2009 We examined the effects of lomerizine on serotonin (5-hydroxytryptamine, 5-HT)– induced contraction of the basilar artery and compared them with those of nifedipine.
Masakazu Ishii +5 more
doaj +1 more source
Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa [PDF]
, 2010 Peer ...
Blundell, John E. +5 more
core +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.This study demonstrates a significant association between the 5‐HTTLPR polymorphism and schizophrenia risk. The short allele was significantly overrepresented in patients (OR = 1.39, p = 0.007), suggesting a potential contribution to schizophrenia risk.
Masao Miyachi +8 more
wiley +1 more source
Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo. [PDF]
PLoS ONE, 2013 Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and signaling contribute to many inflammatory related diseases.
Felix Nau +3 more
doaj +1 more source
M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]
, 2017 Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa +2 more
core +1 more source
Regulation of 5-HT2A receptor mRNA in P11 cells
Behavioural Brain Research, 1995 P11 cells were used as an in vitro model system to explore effects of exposure to 5-HT on levels of mRNA encoding 5-HT2A receptors. Exposure of cells to the agonist 5-HT resulted in a doubling of receptor mRNA levels. mRNA levels returned to control levels within 8-16 h.
R C, Ferry, P B, Molinoff
openaire +2 more sources
Decreased density of serotonin 5-HT2A receptors in rheumatoid arthritis [PDF]
Annals of the Rheumatic Diseases, 2006 Animal studies have indicated that 5-HT2A receptors could play a role in arthritic diseases.To analyse the binding properties of 5-HT2A receptors in patients with rheumatoid arthritis.Using a radioactive binding assay, 43 patients with rheumatoid arthritis were compared with 49 sex and age matched controls for density and affinity (measured as Bmax and
A, Kling +3 more
openaire +2 more sources
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.This graphical summary illustrates the efficacy and safety of brexpiprazole (2–4 mg) in patients with schizophrenia. The meta‐analysis demonstrates significant improvement in clinical outcomes, with reductions in Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression ‐ Severity scale (CGI‐S) scores, indicating better symptom ...
Sher Bano +14 more
wiley +1 more source
Frontiers in NeuroscienceIntroductionStudies suggest that serotonin (5-HT) plays an important role in alcohol use disorder (AUD). While several receptor subtypes modulate the role of 5-HT in AUD, evidence suggests that 5-HT2A and 5-HT2C receptors may be directly involved in ...
Sandy C. Simões +15 more
doaj +1 more source