Results 201 to 210 of about 125,938 (267)

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT_2C Receptor Agonists

, 2015
Guy Rouquet, Dianna E. Moore, Malcolm Spain, Daniel M. Allwood, Claudio Battilocchio, David C. Blakemore, Paul V. Fish, Stephen Jenkinson, Alan S. Jessiman, Steven V. Ley, Gordon McMurray, Richard Storer   +11 more
openalex   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Association of serotonin and ergot alkaloids on tissue partitioning and contractile response of bovine blood vessels. [PDF]

Curr Res Toxicol
Valente EEL, Harmon DL, May J, Ji H, Trotta RJ, Klotz JL.   +5 more
europepmc   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Malignant hypertension and pseudohyperaldosteronism associated with rifampicin therapy. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Szedleski A, Ilbert C, Goncette V, Vroonen L, Huart J.   +4 more
europepmc   +1 more source

Synthesis and Structure–Affinity Relationships of Selective High-Affinity 5-HT₄Receptor Antagonists: Application to the Design of New Potential Single Photon Emission Computed Tomography Tracers

, 2012
Emmanuelle Dubost⧫, Noé Dumas, Christine Fossey, R. Magnelli, Sabrina Butt‐Gueulle, Céline Ballandonne, Daniel H. Caignard, Fabienne Dulin, Jana Sopkova de-Oliveira Santos, P. Millet, Yves Charnay, Sylvain Rault, Thomas Cailly, Frédéric Fabis   +13 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Production, Mechanisms, and Therapeutic Strategies of Tryptophan Metabolites in CNS Diseases. [PDF]

Mol Neurobiol
Shi C, Dong J, Hui X, Xu Z, Zhao Z, Dong L.   +5 more
europepmc   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +1 more source