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Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium
1990Receptors for 5-hydroxytryptamine (5-HT) on myocardial cells differ among species and even among different heart regions of the same species. In molluscs 5-HT enhances heart force and cyclic AMP, and lysergic acid diethylamide (LSD) is a potent agonist. In human atria 5-HT, but not LSD, increases contractile force through unknown receptors (not blocked
Alberto J. Kaumann +5 more
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Molecular biology of 5-HT receptors
Trends in Pharmacological Sciences, 1989Within the past six months, isolation of cDNA or genomic clones has been reported for three 5-HT receptors, the 5-HT1C, 5-HT1A and 5-HT2 subtypes. As members of the G protein receptor superfamily, all three 5-HT receptor clones encode single-subunit proteins containing approximately 450 amino acids arrayed as seven interconnected transmembrane segments.
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The behavioural response to 5-HT receptor agonists and subtypes of the central 5-HT receptor
Trends in Pharmacological Sciences, 1985Abstract The analysis of the role of 5-hydroxytryptamine (5-HT)-containing neurons in the control of behaviour is complicated by the diverse functional effects that may follow the activation of the multiple types of recognition site for 5-HT that have recently been identified in the CNS, and the lack of specificity inherent in many of the 5-HT ...
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Discriminating between 5-HT₃A and 5-HT₃AB receptors.
British journal of pharmacology, 2014The 5-HT3B subunit was first cloned in 1999, and co-expression with the 5-HT3A subunit results in heteromeric 5-HT₃AB receptors that are functionally distinct from homomeric 5-HT₃A receptors. The affinities of competitive ligands at the two receptor subtypes are usually similar, but those of non-competitive antagonists that bind in the pore often ...
A J, Thompson, S C R, Lummis
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MDP and 5-HT receptors. Does MDP interact with 5-HT(7) receptors?
International journal of immunopharmacology, 2000A possible interaction of immunomodulator muramyl dipeptide (MDP) with 5-HT(7) (5-hydroxytryptamine) receptors was investigated. The activation of 5-HT(7) receptors relaxes the guinea-pig distal ileum. The whole ileum segments were, therefore, cut and placed into the bath.
J, Sevcík +3 more
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1990
Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the ...
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Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the ...
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Electrophysiology of 5-HT Receptors
2000Within the past decade, molecular cloning techniques have confirmed that 5-hydroxytryptamine (5-HT) receptor subtypes, originally predicted from radioligand binding and functional studies (e.g., 5-HT1, 5-HT2, 5-HT3, 5-HT4), represent separate and distinct gene products. This knowledge has had a crucial impact on electrophysiological approaches to the 5-
G. K. Aghajanian, R. Andrade
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