Results 11 to 20 of about 69 (69)

The impact of re‐characterizing metastatic pancreatic neuroendocrine tumors: A prospective study

Journal of Neuroendocrinology, EarlyView.
Abstract The biology of metastatic pancreatic neuroendocrine tumors (panNET) may alter over time. It remains to be defined if, how, and when this patient group should be recommended to re‐evaluate the characteristics of their disease. This prospective single‐center, longitudinal cohort study at Uppsala University Hospital, Sweden (NCT03130205 ...
Kazhan Mollazadegan, Johan Botling, Britt Skogseid, Barbro Eriksson, Lovisa Falkman, Liang Zhang, Ieva Lase, Staffan Welin, Anders Sundin, Joakim Crona   +9 more
wiley   +1 more source

MRI‐based surrogates of brain clearance in narcolepsy type 1

Journal of Sleep Research, EarlyView.
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy.
Eva M. van Heese, Jari K. Gool, Gert Jan Lammers, Ysbrand D. van der Werf, Matthias J. P. van Osch, Rolf Fronczek, Lydiane Hirschler   +6 more
wiley   +1 more source

Docosahexaenoic Acid and Nervonic Acid Synergically Enhance Cognitive Memory in Normal Mice via Brain Fatty Acids Remodeling

eFood, Volume 6, Issue 3, June 2025.
1. DHA and NA can enhance memory by increasing their levels in gray and white matter. 2. DHA and NA can enhance memory by increasing their levels in gray and white matter. 3. DHA and NA combination regulate spatial memory in a dose‐specific manner. ABSTRACT Docosahexaenoic acid (DHA) and nervonic acid (NA) are the main components of brain gray and ...
Hai‐Yan Ou, Lei Feng, Rui‐Ye Chen, Hui‐Yun Lu, Shuang Cai, Zhi‐You Yang   +5 more
wiley   +1 more source

Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling

iMeta, Volume 4, Issue 3, June 2025.
Compared to healthy controls, children with food‐sensitized tolerance and food allergy showed reduced fecal short‐chain fatty acids (SCFAs), particularly butyrate. In an ovalbumin‐sensitized mouse model, butyrate outperformed other SCFAs in alleviating allergic responses.
Jialu Shi, Wenjun Mao, Yuqing Song, Yuxin Wang, Lili Zhang, Yan Xu, Huiwen Gu, Siyu Yao, Yuanhang Yao, Zhifeng Liu, Vijaya Raghavan, Jin Wang   +11 more
wiley   +1 more source

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan‐related metabolites for health longevity in centenarians

iMeta, Volume 4, Issue 3, June 2025.
Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu, Chao Mu, Jie Hu, Jiaxin Yu, Wenbo Tang, Yueli Liu, Yongmei Huang, Yixian Lu, Peihua Tang, Jingzhen Wu, Zixuan Huang, Xianlin Mei, Huaguo Xiang, Hao Lin, Yi Qi, Hui Luo, Xuemeng Li   +16 more
wiley   +1 more source

Patients with Allan‐Herndon‐Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment

Movement Disorders, Volume 40, Issue 5, Page 938-949, May 2025.
Abstract Background Patients with mutations in the monocarboxylate transporter 8 (MCT8, SLC16A2) suffer from X‐linked recessive Allan‐Herndon‐Dudley syndrome (AHDS), which is characterized by developmental delay and a severe movement disorder. Current trials using thyroid hormone derivatives to overcome the transporter defect have failed to achieve ...
Nina‐Maria Wilpert, Angela L. Hewitt, Roser Pons, Marie‐Thérèse Henke, Andrea Dell'Orco, Martin Bauer, Christiane Grolik, Stephan Menz, Monika Wahle, Annika Zink, Alessandro Prigione, Christina Reinauer, Catharina Lange, Christian Furth, Knut Brockmann, Sabine Jung‐Klawitter, Stine Christ, Angela M. Kaindl, Anna Tietze, Heiko Krude, Thomas Opladen, Markus Schuelke   +21 more
wiley   +1 more source

European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption

United European Gastroenterology Journal, Volume 13, Issue 4, Page 599-613, May 2025.
ABSTRACT Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac ...
Marco Vincenzo Lenti, Heinz Florian Hammer, Ilja Tacheci, Rosa Burgos, Stephane Schneider, Anastasiou Foteini, Aleksejs Derovs, Jutta Keller, Ilse Broekaert, Marianna Arvanitakis, Dan Lucian Dumitrascu, Oscar Segarra‐Cantón, Željko Krznarić, Juris Pokrotnieks, Gonçalo Nunes, Johann Hammer, Loris Pironi, Marc Sonyi, Cristina Maria Sabo, Juan Mendive, Adrien Nicolau, Jernej Dolinsek, Denisa Kyselova, Lucrezia Laterza, Antonio Gasbarrini, Teodora Surdea‐Blaga, Jorge Fonseca, Christos Lionis, Gino Roberto Corazza, Antonio Di Sabatino   +29 more
wiley   +1 more source

Burn‐Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan‐Kynurenine Mediated AHR Pathway Activation

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study elucidates a pivotal crosstalk between the gut microbiota and skeletal muscles atrophy induced by burn injuries, a process fueled by the overactivation of IDO‐1 in the colon. This overactivation initiates the metabolism of tryptophan into kynurenine.
Shan Gao, Yan Leng, Zhen Qiu, Kai Li, Jun Li, Jian Peng, Weiguo Xie, Shaoqing Lei, Zhongyuan Xia   +8 more
wiley   +1 more source

Metabolomics and Microbiomics Perspectives Reveal the Regulatory Pathways of Monaphilone B Derived From Red Yeast Rice on Alcoholic Liver Injury in Mice

eFood, Volume 6, Issue 2, April 2025.
Monaphilone B (MB) from red yeast rice mitigates alcoholic liver injury through the regulation of the gut microbiome, liver metabolism, lipid metabolism, and oxidative defense. ABSTRACT Red yeast rice (RYR) has been extensively used as a natural food for thousands of years and still plays an important role in the world food industry. In this study, the
Li Wu, Zihua Liang, Ziyi Yang, Hao Wang, Li Ni, Weiling Guo, Xucong Lv   +6 more
wiley   +1 more source

The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression

Cancer Medicine, Volume 14, Issue 6, March 2025.
ABSTRACT Tryptophan (Trp), an essential amino acid, is solely acquired through dietary intake. It is vital for protein biosynthesis and acts as a precursor for numerous key bioactive compounds. The Kynurenine Pathway and the Indole Pathway are the main metabolic routes and are extensively involved in the occurrence and progression of diseases in the ...
Zhanhui Lu, Chengcheng Zhang, Jia Zhang, Wan Su, Guoying Wang, Zhongqi Wang   +5 more
wiley   +1 more source