Results 211 to 220 of about 12,448,100 (233)

Label-Free and Template-Free Chemiluminescent Biosensor for Sensitive Detection of 5-Hydroxymethylcytosine in Genomic DNA.

Analytical Chemistry, 2021
5-Hydroxymethylcytosine (5hmC) is a modified base present at low levels in various mammalian cells, and it plays essential roles in gene expression, DNA demethylation, and genomic reprogramming.
Chen-chen Li, Yue Dong, Xiaoran Zou, Xiliang Luo, Dazhong Shen, Juan Hu, Chun-yang Zhang   +6 more
semanticscholar   +1 more source

NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion

Proceedings of the National Academy of Sciences of the United States of America
Significance The mechanism and fate by which the dynamic modification of m5C on RNA remain unclear. Here, we report that the canonical 28SrRNA methyltransferase NSUN5 which is epigenetically suppressed by DNA methylation is capable of introducing m5C ...
Ruixin Wu, Chunming Sun, Xi Chen, Runyue Yang, Yuxuan Luan, Xiang Zhao, Panpan Yu, Rongkui Luo, Yingyong Hou, Ruotong Tian, Shasha Bian, Yuli Li, Ying-ying Dong, Qian Liu, Weiwei Dai, Zhuoyang Fan, Rucheng Yan, Binyang Pan, Si-Yu Feng, Jing Wu, Fangzhen Chen, Changlei Yang, Hanlin Wang, Hao Dai, Minfeng Shu   +24 more
semanticscholar   +1 more source

Advances in DNA methylation: 5-hydroxymethylcytosine revisited

Clinica Chimica Acta, 2011
Mammalian DNA contains two modified cytosine bases; 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Both of these have been known for decades but have received very different levels of attention in the scientific literature. 5mC has been studied extensively, and its role as an epigenetic modification involved in gene regulation, X-chromosome
Christina, Dahl, Kirsten, Grønbæk, Per, Guldberg   +2 more
openaire   +2 more sources

The Elusive Role of 5′-Hydroxymethylcytosine

Epigenomics, 2016
5'-hydroxymethylcytosine (5hmC) is a variant of the common covalent epigenetic modification of DNA 5'-methylcytosine (5mC). Although the presence of this modified base in mammalian DNA has been recognized for several decades, it has recently gained center stage as a suspected intermediate in enzymatic active demethylation of 5mC.
openaire   +2 more sources

5-Hydroxymethylcytosine Profiling in Human DNA

2015
Since its "re-discovery" in 2009, there has been significant interest in defining the genome-wide distribution of DNA marked by 5-hydroxymethylation at cytosine bases (5hmC). In recent years, technological advances have resulted in a multitude of unique strategies to map 5hmC across the human genome.
John P, Thomson, Colm E, Nestor, Richard R, Meehan   +2 more
openaire   +2 more sources

The role of 5-hydroxymethylcytosine in melanoma

Melanoma Research, 2017
Malignant melanoma is a highly aggressive neoplasia of melanocytic origin. In part because of the lack of effective treatment methods, the incidence and mortality rates of this disease continue to increase. Rapidly accumulating evidence suggests that dysregulation of epigenetic mechanisms, including DNA methylation/demethylation, chromatin modification,
Feng-Juan, Li, Li-Ming, Li, Rui-Hua, Zhang, Cui, Xu, Pan, Zhou, Jia, Long, Gang, Hu, Ming-Jun, Jiang   +7 more
openaire   +2 more sources

[Progress of research on 5-hydroxymethylcytosine].

Yi chuan = Hereditas, 2012
5-methylcytosine (5mC) in cytosine-guanine dinucleotide (CpG) is a usual epigenetic modification in mammals. It plays crucial roles in gene regulation, development, genomic imprinting and so on. In the last three years, it was discovered that in addition to 5mC, another modified cytosine base-5-hydroxymethylcytosine (5hmC) was abundant in many ...
Yan-Xia, Zhang, Ke-Run, Gao, Shun-Ying, Yu   +2 more
openaire   +3 more sources

Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA

Organic Letters, 2010
5-Hydroxymethylcytosine ((5-HOMe)dC) was recently discovered as the sixth base in the mammalian genome. The development of a new phosphoramidite building block is reported, which allows efficient synthesis of (5-HOMe)dC containing DNA. Key steps of the synthesis are a palladium-catalyzed formylation and the simultaneous protection of a hydroxyl and ...
Münzel M, Globisch D, Trindler C, Carell T   +3 more
openaire   +3 more sources

5‐Hydroxymethylcytosine, the Sixth Base of the Genome

Angewandte Chemie International Edition, 2011
Abstract5‐Hydroxymethylcytosine (hmC) was recently discovered as a new constituent of mammalian DNA. Besides 5‐methylcytosine (mC), it is the only other modified base in higher organisms. The discovery is of enormous importance because it shows that the methylation of cytosines to imprint epigenetic information is not a final chemical step that leads ...
Münzel M, Globisch D, Carell T
openaire   +3 more sources

Perturbations of 5-Hydroxymethylcytosine Patterning in Hematologic Malignancies

Seminars in Hematology, 2013
The recent identification of covalent cytosine modifications derived from the metabolism of 5-methylcytosine (5-mC) and catalyzed by the TET proteins has facilitated molecular insight into a new subclass of acute myeloid leukemias (AMLs). TET2-mutant AMLs have the predicted hypermethylation phenotype expected given the inability of the mutant TET2 ...
Jozef, Madzo, Aparna, Vasanthakumar, Lucy A, Godley   +2 more
openaire   +2 more sources