Results 221 to 230 of about 12,448,100 (233)

Global DNA 5‐Hydroxymethylcytosine and 5‐Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma

Hepatology, 2018
Methylation of the fifth position of cytosine (5mC) is an important epigenetic modification of DNA. It has been shown that the oxidized derivatives of 5mC, namely 5‐hydroxymethylcytosine (5hmC), 5‐formylcytosine (5fC), and 5‐carboxylcytosine (5caC), are ...
Jiao Liu, Jinhua Jiang, Jiezhen Mo, Dan Liu, Dan Cao, Hailin Wang, Yufei He, Hongyang Wang   +7 more
semanticscholar   +1 more source

5-Hydroxymethylcytosine: a Potential Therapeutic Target in Cancer

Epigenomics, 2014
The ten-eleven translocation enzymes catalyze the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, a distinct epigenetic mark that has an integral role in active demethylation. Genes that regulate the distribution and amount of 5-hydroxymethylcytosine in the genome could be suitable therapeutic targets to correct abnormal methylation in ...
Euan J, Rodger, Aniruddha, Chatterjee, Ian M, Morison   +2 more
openaire   +2 more sources

Nonenzymatic Labeling of 5‐Hydroxymethylcytosine in Nanopore Sequencing

ChemBioChem, 2013
Labeling chemically for a "single" result: A one-step, nonenzymatic 5hmC thiolation method mediated by bisulfite is highlighted. The 5hmC base can be chemically labeled in single-stranded DNA and detected by using nanopore sequencing.
Xingyu, Lu, Chuan, He
openaire   +2 more sources

Spectroscopic Quantification of 5-Hydroxymethylcytosine in Genomic DNA

Analytical Chemistry, 2014
5-Hydroxymethylcytosine (5hmC), a modified form of the DNA base cytosine, is an important epigenetic mark linked to regulation of gene expression in development, and tumorigenesis. We have developed a spectroscopic method for a global quantification of 5hmC in genomic DNA.
Tamar Shahal, Noa Gilat, Yael Michaeli, Orit Redy-Keisar, Doron Shabat, Yuval Ebenstein   +5 more
openaire   +2 more sources

Altered 5-Hydroxymethylcytosine Landscape in Primary Gastric Adenocarcinoma

DNA and Cell Biology, 2019
Multiple factors, including genetic and epigenetic fluctuations, have been linked to gastric cancer formation and progression. Cytosine methylation (5mC) has been recognized as a critical epigenetic mark in the mammalian genome. The recent discovery of 5-hydroxymethylcytosine (5hmC), which is generated by ten-eleven translocation (TET) enzymes ...
Hao, Liu, Tianlei, Xu, Ying, Cheng, Michael H, Jin, Margaret Y, Chang, Qiang, Shu, Emily G, Allen, Peng, Jin, Xudong, Wang   +8 more
openaire   +2 more sources

5-Hydroxymethylcytosine-containing Klebsiella bacteriophage

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
N I, Anisymova, I M, Gabrilovich, N V, Soshina, S N, Cherenkevich   +3 more
openaire   +2 more sources

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Nature, 2011
G. Ficz, Miguel R. Branco, Stefanie Seisenberger, Fátima Santos, Felix Krueger, T. Hore, C. Marques, S. Andrews, W. Reik   +8 more
semanticscholar   +1 more source

Electrochemical sensor for the analysis of 5-hydroxymethylcytosine in the presence of cytosine using pencil graphite electrode.

Analytical Biochemistry
S. Bilge, Manolya Müjgan Gürbüz, S. Ozkan, Burcu Dogan Topal   +3 more
semanticscholar   +1 more source

Enzymatic Labeling of 5‐Hydroxymethylcytosine in DNA

Angewandte Chemie International Edition, 2011
openaire   +3 more sources

Synthesis of 5-Hydroxymethylcytosine

Journal of the American Chemical Society, 1955
openaire   +1 more source