Results 171 to 180 of about 88,028,942 (209)

A new synthetic approach for novel 4-substituted-5-nitroimidazoles

Tetrahedron Letters, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Maxime D. Crozet, Patricia Perfetti, Mustapha Kaafarani, Patrice Vanelle, Michel P. Crozet   +4 more
openaire   +1 more source

Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore

European Journal of Medicinal Chemistry, 2009
To improve the antiparasitic pharmacophore, 20 5-nitroimidazoles bearing an arylsulfonylmethyl group were prepared from commercial imidazoles. The antiparasitic activity of these molecules was assessed against Trichomonas vaginalis, the in vitro cytotoxicity was evaluated on human monocytes and the mutagenicity was determined by the Salmonella ...
Maxime D, Crozet, Céline, Botta, Monique, Gasquet, Christophe, Curti, Vincent, Rémusat, Sébastien, Hutter, Olivier, Chapelle, Nadine, Azas, Michel, De Méo, Patrice, Vanelle   +9 more
openaire   +2 more sources

Resistance to 5-Nitroimidazoles in Pathogenic Microorganisms

1982
Resistance (lowered susceptibility) to metronidazole and other 5-nitroimidazoles occurs, albeit infrequently, in clinical isolates of the normally susceptible anaerobic microorganisms, Trichomonas vaginalis and Bacteroides spp. Such resistance has been induced by in vivo drug pressure in T.
openaire   +1 more source

Hydrogenosome: The Site of 5-Nitroimidazole Activation and Resistance

2007
Derivatives of 5-nitroimidazole, such as metronidazole or tinidazole, are the drugs of choice for treatment of sexually transmitted infections of humans caused by the parasitic protist Trichomonas vaginalis. These drugs with selective activity against anaerobic and microaerophilic microorganisms enter the trichomonad cell and accumulate in ...
Jaroslav Kulda, Ivan Hrdý
openaire   +1 more source

2-Amino-5-nitroimidazoles

Journal of Medicinal Chemistry, 1971
L F, Miller, R E, Bambury
openaire   +2 more sources

Activation in vivo of 5-nitroimidazoles

Mutation Research/Environmental Mutagenesis and Related Subjects, 1982
M.A. Belisario, F. De Lorenzo, E. De Marinis   +2 more
openaire   +1 more source

2-Methyl-5-nitroimidazole

2021
openaire   +1 more source

2-Metil-5-nitroimidazol

2022
openaire   +1 more source

Mechanism of metabolic activation of ronidazole, a 5-nitroimidazole

Biochemical Society Transactions, 1984
A Y, Lu, P G, Wislocki, E S, Bagan, R W, Wang, J S, Walsh, G T, Miwa   +5 more
openaire   +2 more sources

Action of clinically utilized 5-nitroimidazoles on microorganisms.

Scandinavian journal of infectious diseases. Supplementum, 1981
Various nitroimidazoles are used as antimicrobial and radiosensitizing agents in human medicine. Of these, 5-nitroimidazoles show high selective toxicity for anaerobic prokaryotes and eukaryotes. This review discusses the effects of 5-nitroimidazoles on microorganisms, i.e.
openaire   +1 more source