Results 171 to 180 of about 14,177 (223)

A Convenient Synthesis of Highly Conjugated 5-Nitroimidazoles

HETEROCYCLES, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kamel Benakli, Thierry Terme, Jose Maldonado, Patrice Vanelle   +3 more
openaire   +1 more source

Cross-resistance of trichomonads to 5-nitroimidazole-derivatives

Experientia, 1976
The strainT. foetus KV 1/M 100, a sub-strain ofT. foetus Kv 1, was made highly resistant to metronidazole by several passages in mice under increasing drug pressure. This drug resistance was accompained by a remarkable cross-resistance to all 5-nitroimidazole-derivatives tested in vitro and in vivo.
J G, Meingassner, H, Mieth
openaire   +2 more sources

Radiosensitization by Metal Complexes of 4(5)-nitroimidazole

International Journal of Radiation Biology, 1990
Four closely-related cis-platinum (Pt) complexes of 4(5)-nitroimidazole have been examined with respect to properties of radiobiological interest, to test the hypothesis that targeting a nitroimidazole (NO2Im) to DNA could enhance its radiosensitizing ability: I [PtCl2(5-NO2Im)2]; II [PtCl2(4-NO2Im)2]; III [PtCl2(NH3)(5-NO2Im)]; IV [PtCl2(NH3)(4-NO2Im)]
K A, Skov, N P, Farrell
openaire   +2 more sources

A comparative study on vibrational, conformational and electronic structure of 1,2-dimethyl-5-nitroimidazole and 2-methyl-5-nitroimidazole

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012
The FTIR and FT-Raman spectra of 1,2-dimethyl-5-nitroimidazole and 2-methyl-5-nitroimidazole have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The conformational analyses were performed and the energies of the different possible conformers were determined.
V, Arjunan, P, Ravindran, R, Santhanam, Arushma, Raj, S, Mohan   +4 more
openaire   +2 more sources

1-Methyl-2-methylthio-5-nitroimidazole, C5H7N3O2S

Acta Crystallographica Section C Crystal Structure Communications, 1994
In the title molecule, the imidazole ring is almost coplanar with the neighbouring attached ...
T. A. Olszak, O. M. Peeters, N. M. Blaton, C. J. De Ranter   +3 more
openaire   +1 more source

Mammalian spot test with moxnidazole, a 5-nitroimidazole

Experientia, 1978
Moxnidazole [3-(5-nitrol-1-methyl-2-imidazolyl)-methyleneamino-5-morpholinomethyl-2-oxazolidinone, HCl], known to be mutagenic in microbial tests and Drosophila, induced genetic alterations in somatic cells of mice. Ethyl methanesulfonate (EMS) served as positive control.
openaire   +2 more sources

5-Nitroimidazole derivatives as possible antibacterial and antifungal agents

Il Farmaco, 1999
Some novel 1-[2-[[5-(2-furanyl)-4-substituted 4H-1,2,4-triazol-3-yl[thio[ethyl[-2-methyl-5-nitro-1H-imidazoles (3), 1-[3-[[5-(2-furanyl/2-thienyl)-4-substituted 4H-1,2,4-triazol-3-yl[-thio]-2-hydroxypropyl[-2-methyl-5-nitro-1H- imidazoles (5) and 1-[3-[(N,N-disubstituted thiocarbamoyl)-thio[-2-hydroxypropyl]-2-methyl-5-nitro-1H-imidazoles (7) were ...
N S, Günay, G, Capan, N, Ulusoy, N, Ergenç, G, Otük, D, Kaya   +5 more
openaire   +2 more sources

Genetics of Resistance of Bacteroides Species to 5-Nitroimidazole

Clinical Infectious Diseases, 1993
Thirty-three clinical isolates of Bacteroides strains with a moderate-to-high level of resistance to 5-nitroimidazole were compared with three strains previously studied by Southern blotting of their DNA. Whether plasmid-borne or chromosomally determined, all genetic determinants that are resistant to 5-nitroimidazole belong to two hybridization groups.
G, Reysset, A, Haggoud, M, Sebald
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Transferable 5-Nitroimidazole resistance in the Bacteroides fragilis group

Plasmid, 1989
We report the characterization of a strain of Bacteroides vulgatus, BV17, that exhibits a moderate resistance to 5-nitroimidazoles and carries plasmids of 4.5, 5, 7.7, and 56 kb. A genetic determinant involved in this resistance is carried by the 7.7 +/- 0.2-kb plasmid (pIP417).
J, Breuil, A, Dublanchet, N, Truffaut, M, Sebald   +3 more
openaire   +2 more sources

Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore

European Journal of Medicinal Chemistry, 2009
To improve the antiparasitic pharmacophore, 20 5-nitroimidazoles bearing an arylsulfonylmethyl group were prepared from commercial imidazoles. The antiparasitic activity of these molecules was assessed against Trichomonas vaginalis, the in vitro cytotoxicity was evaluated on human monocytes and the mutagenicity was determined by the Salmonella ...
Maxime D, Crozet, Céline, Botta, Monique, Gasquet, Christophe, Curti, Vincent, Rémusat, Sébastien, Hutter, Olivier, Chapelle, Nadine, Azas, Michel, De Méo, Patrice, Vanelle   +9 more
openaire   +2 more sources