Results 151 to 160 of about 88,028,942 (209)

Trichomoniasis refractory to 5-nitroimidazole therapy in Trinidad

Tropical Doctor, 2022
Trichomoniasis is the most common non-viral sexually transmitted infection (STI) occurring worldwide and the majority of infected persons (70–85%) have mild or no genital symptoms. Symptoms in women may include a vaginal discharge which may be associated with vulval irritation and most infections can be effectively treated with metronidazole 500mg bd ...
Robert Jeffrey Edwards, Miriam Parboo, Jonathan Edwards, Gregory Boyce   +3 more
openaire   +2 more sources

A Comparative Study on Vibrational, Conformational and Electronic Structure of 1,2-Dimethyl-5-Nitroimidazole and 2-Methyl-5-Nitroimidazole

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2012
The FTIR and FT-Raman spectra of 1,2-dimethyl-5-nitroimidazole and 2-methyl-5-nitroimidazole have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The conformational analyses were performed and the energies of the different possible conformers were determined.
Velu Arjunan, R Santhanam, P Ravindran
exaly   +3 more sources

RM and log P values of 5-nitroimidazoles

Journal of Chromatography A, 1981
Abstract The chromatographic RM values of a series of nitroimidazoles and their log P values were determined in view of a study of their structure-activity relationships as mutagenic agents. The equations describing the relationship between RM and log P values show a low correlation coefficient.
GUERRA M.C., BARBARO A.M., CANTELLI FORTI G., FOFFANI M.T., BIAGI G.L., BOREA, Pier Andrea, FINI A.   +6 more
openaire   +1 more source

Increased Incidence of Nitroimidazole-Refractory Giardiasis at the Hospital for Tropical Diseases, London: 2008–2013

Clinical Microbiology and Infection, 2015
Giardia intestinalis is the commonest gastrointestinal protozoal pathogen worldwide, and causes acute and chronic diarrhoea with malabsorption. First-line treatment is with a nitroimidazole, with a reported efficacy rate of 89%.
P L Chiodini
exaly   +2 more sources

Radiosensitization by Quaternary Salts of 5-nitroimidazole Derivatives

International Journal of Radiation Biology, 1989
The radiosensitizing effects of five newly synthesized quaternary salts of 5-nitroimidazole derivatives on the survival of TC-SV40 mammalian cells have been measured. A toxicity study was carried out in order to determine the concentrations to be used in the radiosensitizing experiments.
L, Santos, M C, Lopez Zumel, M V, Alvarez, M C, Izquierdo   +3 more
openaire   +2 more sources

Cross-resistance of trichomonads to 5-nitroimidazole-derivatives

Experientia, 1976
The strainT. foetus KV 1/M 100, a sub-strain ofT. foetus Kv 1, was made highly resistant to metronidazole by several passages in mice under increasing drug pressure. This drug resistance was accompained by a remarkable cross-resistance to all 5-nitroimidazole-derivatives tested in vitro and in vivo.
J G, Meingassner, H, Mieth
openaire   +2 more sources

A Convenient Synthesis of Highly Conjugated 5-Nitroimidazoles

HETEROCYCLES, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kamel Benakli, Thierry Terme, Jose Maldonado, Patrice Vanelle   +3 more
openaire   +1 more source

Genetics of Resistance of Bacteroides Species to 5-Nitroimidazole

Clinical Infectious Diseases, 1993
Thirty-three clinical isolates of Bacteroides strains with a moderate-to-high level of resistance to 5-nitroimidazole were compared with three strains previously studied by Southern blotting of their DNA. Whether plasmid-borne or chromosomally determined, all genetic determinants that are resistant to 5-nitroimidazole belong to two hybridization groups.
G, Reysset, A, Haggoud, M, Sebald
openaire   +2 more sources

Radiosensitization by Metal Complexes of 4(5)-nitroimidazole

International Journal of Radiation Biology, 1990
Four closely-related cis-platinum (Pt) complexes of 4(5)-nitroimidazole have been examined with respect to properties of radiobiological interest, to test the hypothesis that targeting a nitroimidazole (NO2Im) to DNA could enhance its radiosensitizing ability: I [PtCl2(5-NO2Im)2]; II [PtCl2(4-NO2Im)2]; III [PtCl2(NH3)(5-NO2Im)]; IV [PtCl2(NH3)(4-NO2Im)]
K A, Skov, N P, Farrell
openaire   +2 more sources

Studies on the disposition of a 5-nitroimidazole in laboratory animals

European Journal of Drug Metabolism and Pharmacokinetics, 1987
The disposition and metabolism of a 5-nitroimidazole compound (SC 28538) was investigated in the rat, beagle dog and rhesus monkey. The absorption of [14C]-SC 28538 was rapid and essentially complete after oral dosage in male animals, and also after intravaginal dosage in the female rat. Peak plasma levels of radioactivity occurred within 2 h of dosage.
A, Barrow, S R, Burford, T J, Forrest, A J, Hawkins, D A, Rose, P M, Stevens, C W, Vose, C M, Walls   +7 more
openaire   +2 more sources