Results 141 to 150 of about 12,654,690 (210)
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Nitrosoimidazoles: highly bactericidal analogs of 5-nitroimidazole drugs
Journal of Medicinal Chemistry, 1988It is believed that metronidazole and related 5-nitroimidazoles are activated by reduction of the nitro group and that the active species has a nitrogen functionality of intermediate oxidation state. However, the preparation and isolation of the active forms of the 5-nitroimidazoles used therapeutically have proven elusive.
W J, Ehlhardt, B B, Beaulieu, P, Goldman
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Transferable 5-Nitroimidazole resistance in the Bacteroides fragilis group
Plasmid, 1989We report the characterization of a strain of Bacteroides vulgatus, BV17, that exhibits a moderate resistance to 5-nitroimidazoles and carries plasmids of 4.5, 5, 7.7, and 56 kb. A genetic determinant involved in this resistance is carried by the 7.7 +/- 0.2-kb plasmid (pIP417).
J, Breuil +3 more
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5-Nitroimidazole derivatives as possible antibacterial and antifungal agents
Il Farmaco, 1999Some novel 1-[2-[[5-(2-furanyl)-4-substituted 4H-1,2,4-triazol-3-yl[thio[ethyl[-2-methyl-5-nitro-1H-imidazoles (3), 1-[3-[[5-(2-furanyl/2-thienyl)-4-substituted 4H-1,2,4-triazol-3-yl[-thio]-2-hydroxypropyl[-2-methyl-5-nitro-1H- imidazoles (5) and 1-[3-[(N,N-disubstituted thiocarbamoyl)-thio[-2-hydroxypropyl]-2-methyl-5-nitro-1H-imidazoles (7) were ...
N S, Günay +5 more
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Diffuse alveolar haemorrhage due to 5‐nitroimidazole treatment
Respirology, 2009ABSTRACTDiffuse alveolar haemorrhage (DAH) is indicated by the presence of red blood cells, fibrin and haemosiderin deposits in the lung parenchyma. We present a case of DAH in a 25‐year‐old male following 5‐nitroimidazole treatment. The first episode of haemoptysis occurred following metronidazole treatment 10 months previously.
Meral, Uyar +5 more
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The Pharmacology and Toxicology of 5-Nitroimidazoles
1982The nitroimidazoles belong to the group of nitroheterocyclic compounds which play an important role as drugs in chemotherapy. The first heterocyclic compound to be used in human medicine was nitrofurazone, a nitrofuran derivative employed during the war for its antibacterial properties for the topical treatment of burns and wounds (1). The discovery of
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Genetics of 5-Nitroimidazole Resistance in Bacteroides
1993Nitroimidazoles are imidazoles that contain a nitro group at position 2, 4, or 5 of the imidazole ring. These compounds may have various substitutions on the nitrogen at position 1 of the imidazole ring. The 5-nitroimidazoles are synthetic compounds that appear to be very potent anaerobicidal agents.
Gilles Reysset +2 more
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Structure of 4(5)-nitroimidazole at 100 K
Acta Crystallographica Section C Crystal Structure Communications, 19934(5)-Nitroimidazole, C 3 H 3 N 3 O 2 , M r =113.08, monoclinic, P2 1 /n, a=6.9559 (4), b=9.9130 (6), c=7.3045 (4) A, β=119.41 (4) o , V=438.8 (4) A 3 , Z=4, D m (293 K)=1.64, D x =1.7117 Mg m -3 , λ(Mo Kα)=0.71069 A, μ=0.1367 mm -1 , F(000)=232, T=100 K. Final R=0.024 for 633 unique observed [F≥4σ(F)] reflections.
H. L. De Bondt +4 more
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Studies on the Mechanism of Activation and the Mutagenicity of Ronidazole, a 5-Nitroimidazole
1986Substantial evidence implicates the obligatory nucleophilic attack by water at C4 for the elimination of the carbamate and subsequent immobilization by electrophilic attack on protein thiols. Consequently, the strong correlation between the structural requirements for protein alkylation and for mutagenicity in TA100 suggests a possible role of ...
G T, Miwa +5 more
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